scholarly journals The Role of Prediabetes as a Predictive Factor for the Outcomes in Patients with STEMI. Which Is the Right Range of Glycated Hemoglobin to Adopt in This Setting?

2021 ◽  
Vol 11 (12) ◽  
pp. 5518
Author(s):  
Kyriazoula Chatzianagnostou ◽  
Letizia Guiducci ◽  
Umberto Paradossi ◽  
Alberto Ranieri De Caterina ◽  
Annamaria Mazzone ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Risk Factor ◽  
Prognostic Value ◽  
Glycated Hemoglobin ◽  
Who Guidelines ◽  
One Year ◽  
The Right

Background: Prediabetes (preT2D) is considered a subtle adverse cardiovascular (CV) risk factor after acute myocardial infarction. Glycated hemoglobin (HbA1c) ranges to identify preT2D are different between ADA and WHO guidelines (5.7–6.4 vs. 6.0–6.4%, respectively). Aim: To evaluate the prognostic value of HbA1c different preT2D-ranges and their correlation with demographic, instrumental, and laboratory parameters in STEMI. Methods: A total of 1681 patients (mean age 67 ± 13 years; 1217 males) were enrolled. Admission HbA1c was used to identify patients with no-T2D (<5.7%), HbA1c 5.70–5.99%, and WHO-preT2D with HbA1c 6–6.49%, and T2D (HbA1c ≥ 6.5). Results: HbA1c 5.7–5.99, WHO-preT2D, and T2D progressively correlated with an increasing number of CV risk factors. However, only T2D, but not preT2D, was significantly associated with adverse prognosis (in-hospital and one-year death). Conclusions: PreT2D is correlated with CV risk factors, but not with adverse prognosis as compared to no-T2D. Nonetheless, routine HbA1c testing in the STEMI population and HbA1c-5.7–5.99 patient inclusion in the preT2D category may help to identify those who may benefit from intervention and lifestyle strategies to early prevent preT2D progression.

scholarly journals Incidence and risk factors of delirium after percutaneous coronary intervention in individuals hospitalised for acute myocardial infarction: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e044564
Author(s):  
Kaizhuang Huang ◽  
Jiaying Lu ◽  
Yaoli Zhu ◽  
Tao Cheng ◽  
Dahao Du ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Systematic Review ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Risk Factor ◽  
Meta Analysis ◽  
Coronary Intervention ◽  
Cochrane Library ◽  
Percutaneous Coronary

IntroductionDelirium in the postoperative period is a wide-reaching problem that affects important clinical outcomes. The incidence and risk factors of delirium in individuals with acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI) has not been completely determined and no relevant systematic review and meta-analysis of incidence or risk factors exists. Hence, we aim to conduct a systematic review and meta-analysis to ascertain the incidence and risk factors of delirium among AMI patients undergoing PCI.Methods and analysesWe will undertake a comprehensive literature search among PubMed, EMBASE, Cochrane Library, PsycINFO, CINAHL and Google Scholar from their inception to the search date. Prospective cohort and cross-sectional studies that described the incidence or at least one risk factor of delirium will be eligible for inclusion. The primary outcome will be the incidence of postoperative delirium. The quality of included studies will be assessed using a risk of bias tool for prevalence studies and the Cochrane guidelines. Heterogeneity of the estimates across studies will be assessed. Incidence and risk factors associated with delirium will be extracted. Incidence data will be pooled. Each risk factor reported in the included studies will be recorded together with its statistical significance; narrative and meta-analytical approaches will be employed. The systematic review and meta-analysis will be presented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.Ethics and disseminationThis proposed systematic review and meta-analysis is based on published data, and thus there is no requirement for ethics approval. The study will provide an up to date and accurate incidence and risk factors of delirium after PCI among patients with AMI, which is necessary for future research in this area. The findings of this study will be disseminated through publication in a peer-reviewed journal.PROSPERO registration numberCRD42020184388.

Long-term effects of an intensive prevention program (IPP) after acute myocardial infarction – the IPP Follow-up and Prevention Boost Trial

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
H Wienbergen ◽  
A Fach ◽  
S Meyer ◽  
J Schmucker ◽  
R Osteresch ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Risk Factor ◽  
Prevention Program ◽  
Study Endpoint ◽  
Funding Source ◽  
Risk Factor Control ◽  
One Year

Abstract Background The effects of an intensive prevention program (IPP) for 12 months following 3-week rehabilitation after myocardial infarction (MI) have been proven by the randomized IPP trial. The present study investigates if the effects of IPP persist one year after termination of the program and if a reintervention after &gt;24 months (“prevention boost”) is effective. Methods In the IPP trial patients were recruited during hospitalization for acute MI and randomly assigned to IPP versus usual care (UC) one month after discharge (after 3-week rehabilitation). IPP was coordinated by non-physician prevention assistants and included intensive group education sessions, telephone calls, telemetric and clinical control of risk factors. Primary study endpoint was the IPP Prevention Score, a sum score evaluating six major risk factors. The score ranges from 0 to 15 points, with a score of 15 points indicating best risk factor control. In the present study the effects of IPP were investigated after 24 months – one year after termination of the program. Thereafter, patients of the IPP study arm with at least one insufficiently controlled risk factor were randomly assigned to a 2-months reintervention (“prevention boost”) vs. no reintervention. Results At long-term follow-up after 24 months, 129 patients of the IPP study arm were compared to 136 patients of the UC study arm. IPP was associated with a significantly better risk factor control compared to UC at 24 months (IPP Prevention Score 10.9±2.3 points in the IPP group vs. 9.4±2.3 points in the UC group, p&lt;0.01). However, in the IPP group a decrease of risk factor control was observed at the 24-months visit compared to the 12-months visit at the end of the prevention program (IPP Prevention Score 10.9±2.3 points at 24 months vs. 11.6±2.2 points at 12 months, p&lt;0.05, Figure 1). A 2-months reintervention (“prevention boost”) was effective to improve risk factor control during long-term course: IPP Prevention Score increased from 10.5±2.1 points to 10.7±1.9 points in the reintervention group, while it decreased from 10.5±2.1 points to 9.7±2.1 points in the group without reintervention (p&lt;0.05 between the groups, Figure 1). Conclusions IPP was associated with a better risk factor control compared to UC during 24 months; however, a deterioration of risk factors after termination of IPP suggests that even a 12-months prevention program is not long enough. The effects of a short reintervention after &gt;24 months (“prevention boost”) indicate the need for prevention concepts that are based on repetitive personal contacts during long-term course after coronary events. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Stiftung Bremer Herzen (Bremen Heart Foundation)

scholarly journals Risk Factor Profile Of Young Adults With Acute Myocardial Infarction: A Preliminary Finding

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Mohd Zhafri Mohd Razib ◽  
Azarisman Shah M.Shah ◽  
Jamalludin A.Rahman ◽  
Aszrin Abdullah ◽  
Aida N.S M.Shah ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Emergency Department ◽  
Young Adults ◽  
Risk Factor ◽  
Preliminary Finding ◽  
Cross Sectional ◽  
Risk Factor Profile ◽  
Common Risk Factors

Introduction: Acute myocardial infarction (AMI) is a major cause of death around the world. There are limited studies of risk factor profile in young adults with AMI. This study aimed to assess the risk factor profile of young adults with AMI at the emergency department of Hospital Tengku Ampuan Afzan (HTAA), Kuantan, Pahang. This is a preliminary result of young adults (age between 18 to 45 years old) who presented to the emergency department of HTAA. Materials and Methods: This cross-sectional study was conducted in HTAA from the 31st July 2017 to the 11th June 2018 involving 709 patients who were diagnosed with AMI. Seventy seven patients were less than 45 years old. However, only 55 were recruited for analysis who fulfilled the inclusion and exclusion criteria. Results: The prevalence of young adults with AMI was 10.9% with mean age of 38.8 ± 5.1 years old and 96.4% were male. Eighty percent of the patients were Malay followed by 10.9% Chinese and 9.1% were Indian. 83.6% were married while 14.5% were unmarried and 1.8% were divorcees. Majority of patients (81.8%) had income less than RM4000. The common risk factors of young adults with AMI presented to HTAA was smoking (80%) followed by increased waist circumference (54.5%), obesity (52.7%), hypertension (40%), hypercholesterolaemia (27.2%), family history of ischaemic heart disease (27.2%), and diabetes mellitus (21.8%). Conclusion: AMI in young adults almost exclusively occurs in male. Smoking and obesity were the most common risk factors in young adults with AMI in HTAA.

scholarly journals Prognostic value of the triglyceride-glucose index among non-diabetic patients with acute myocardial infarction at one-year follow-up

2021 ◽  
Vol 79 (10) ◽  
pp. 1116-1123
Author(s):  
Dominika Drwiła ◽  
Paweł Rostoff ◽  
Grzegorz Gajos ◽  
Jadwiga Nessler ◽  
Ewa Konduracka
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Prognostic Value ◽  
Diabetic Patients ◽  
Triglyceride Glucose Index ◽  
One Year

scholarly journals Association of diabetes mellitus and acute myocardial infarction: a study in a semi urban centre

2018 ◽  
Vol 5 (5) ◽  
pp. 1138
Author(s):  
Jella Ramdas ◽  
Vasantha Jella
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Risk Factor ◽  
Previous History ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Urban Centre ◽  
The Mean

Background: Acute myocardial infarction is one of the very common ailments, that quite often ends in mortality. The risk factors for AMI has been identified as smoking, alcoholism, high cholesterol, obesity, left ventricular hypertrophy, high triglyceride levels and diabetes mellitus. This study was done to evaluate diabetes as a risk factor for the incidence of acute myocardial infarction in our area.Methods: Demographic details such as age, sex, height, weight, BMI, blood pressure, details of alcoholism or smoking were taken. Physical examination was conducted for all the patients. Previous clinical and medical history was taken for all the patients. The predictors for calculation of 10 years risk factor for SCORE were age, sex, smoking, cholesterol and triglyceride levels and blood pressure.Results: The mean age of the males was 66.1±2.7 and women was 68.8±4.9. 27.3% of the males and 29.4% of the females were obese while 34.6% of males and 32.4% of females were overweight. The mean random blood sugar among the diabetic patients was around 143.5 mg/dL, and in the non-diabetics it was 84.4mg/dL. Out of the 48 diabetic patients, 32 of them (66.7%) had a previous history of MI while in non-diabetes, 53.7% had a previous MI attack.Conclusions: It is essential for the early detection of diabetes and control of the sugar levels, so as to reduce the risk of cardiovascular ailments, since diabetes is one of the independent risk factors.

scholarly journals Роль инсулинорезистентности, адипокинового, липидного, провоспалительного статусов в оценке риска развития сахарного диабета через год от начала инфаркта миокарда с подъемом сегмента st

2019 ◽  
pp. 6-12
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Roc Curve ◽  
Prognostic Value ◽  
Adiponectin Concentration ◽  
St Elevation ◽  
One Year ◽  
Dm Type 2

The role of biomarkers of insulin resistance, adipokine, lipid and proinflammatory statuses in the development of new cases of diabetes mellitus (DM) type 2 one year after the start of myocardial infarction with ST elevation (MIwST) has been determined. The study included 136 men with MIwST at the age of 58 (53; 70) years. A year after the onset of myocardial infarction, diabetes debuted in 20 (14,7 %) patients. It has been established that the HOMA-IR index ≥2,77 possesses the greatest prognostic value in relation to the development of diabetes a year after IM on the 12th day of IM; 95 (0,92; 0,99), the sensitivity of the predictive value of the indicator – 95,0, specificity – 47,4. Also, an increase in the risk of diabetes is determined with an increase in the serum on the 12th day of IM levels of biomarkers such as: insulin ≥12,7 μIUml, the area under the ROC curve is 0,95 (0,91; 0,98), sensitivity – 95,0, specificity – 73,3; leptin ≥5,77 ng/ml, the area under the ROC curve is 0,76 (0,65; 0,87), sensitivity is 90,0, specificity is 45,7; interleukin-6 (IL-6) ≥5,7 pg/ml, the area under the ROC-curve – 0,73 (0,61; 0,86), sensitivity – 95,0, specificity – 28,4; free fatty acids (FFA) ≥0,61 mmol/l, the area under the ROC curve is 0,70 (0.56;0,84), sensitivity is 65,0, specificity is 44,0. With an increase in adiponectin concentration ≥8,2 µg / ml on the 12th day of IM, the likelihood of developing diabetes after a year from the onset of IM is reduced by 28,0 %, the area under the ROC curve is 0,74 (0,64; 0,85), sensitivity – 82,8, specificity – 35,0. When forming groups of patients with MIwST with a high risk of developing type 2 diabetes, the HOMA-IR index, insulin, leptin, IL-6, FFA, adiponectin levels determined on the 12th day of IM in serum should be taken into account.

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