scholarly journals Alpha-Glucosidase Inhibitory Activity of Garcinia lateriflora Blume Leaves

2017 ◽  
Keyword(s):  
Inhibitory Activity ◽  
Alpha Glucosidase

scholarly journals ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITION ACTIVITY OF SELECTED EDIBLE SEAWEEDS FROM SOUTH COAST AREA OF INDIA

2017 ◽  
Vol 9 (6) ◽  
pp. 64 ◽  
Author(s):  
P. Reka ◽  
Thahira Banu A. ◽  
M. Seethalakshmi
Keyword(s):  
Aqueous Extract ◽  
Inhibitory Activity ◽  
Alpha Amylase ◽  
Postprandial Blood Glucose ◽  
Inhibition Activity ◽  
Gracilaria Edulis ◽  
Edible Seaweeds ◽  
Daily Diet ◽  
Postprandial Blood Glucose Level ◽  
Alpha Glucosidase

Objective: The present work was to investigate the alpha amylase and alpha-glucosidase inhibitory activity of the selected edible seaweeds.Methods: The seaweeds namely Acanthophora spicifera, Gracilaria corticata, Gracilaria edulis, Ulva lactuca and Ulva reticulata were selected for this study. Six and eight hours of ethanol and aqueous extract were used for the estimation of alpha amylase using DNS method and alpha-glucosidase inhibition activity.Results: The study reported that the solvent from ethanol and aqueous in eight hours of extraction showed a higher inhibitory activity than six hours of extraction. Maximum of 89.1±0.96 and 79.55±3.08 percent of alpha-amylase and alpha-glucosidase inhibition activity were detected in the eight hours of aqueous extract (0.5 ml) of Ulva reticulata and Gracilaria edulis respectively. All the selected edible seaweeds had significant differences (p<0.05) in alpha amylase and alpha glucosidase inhibition activity between the selected seaweeds with different extracts.Conclusion: It was concluded that all the selected edible seaweeds have the potential to act as a potent inhibitor of the carbohydrate hydrolyzing enzyme. Thus, it was clear from the study that seaweeds incorporated in small amounts in the dishes consumed in the daily diet can bring a control on postprandial blood glucose level.

scholarly journals Nutritional Composition and .ALPHA.-Glucosidase Inhibitory Activity of Five Chinese Vinegars

2011 ◽  
Vol 45 (4) ◽  
pp. 445-456 ◽  
Author(s):  
JunFeng FAN ◽  
YanYan ZHANG ◽  
LinNa ZHOU ◽  
ZaiGui LI ◽  
BoLin ZHANG ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Nutritional Composition ◽  
Alpha Glucosidase

scholarly journals Antioxidant, anti-cholinesterase, anti-α-glucosidase and prebiotic properties of beta-glucan extracted from Algerian barley

2018 ◽  
Vol 10 (1) ◽  
pp. 58 ◽  
Author(s):  
Saad Mebrek ◽  
Hanene Djeghim ◽  
Yamina Mehdi ◽  
Asma Meghezzi ◽  
Sirajudheen Anwar ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Reducing Power ◽  
Beta Carotene ◽  
Moderate Activity ◽  
Beta Glucan ◽  
Antioxidant Power ◽  
Camel's Milk ◽  
Therapeutic Properties ◽  
Alpha Glucosidase ◽  
Low Activity

<p>Beta-glucan, such as barley-derived beta-glucan (BBG), are homopolysaccharides that have attracted attention by their nutritional and therapeutic properties. The aim of this study was to evaluate the antioxidant power of BBG extracted from local Algerian variety of barley (SAIDA 183), and its acetylcholinesterase, alpha glucosidase inhibitory activity as well as its prebiotic potential by fermentation with lactic acid bacteria isolated from camel’s milk, namely <em>lactococcuslactisssplactis</em> (Lc.l.l) and <em>leuconostocmesenteroidesspmesenteroides</em> (Ln.m.m). The results revealed that BBG exhibited low activity against DPPH and ferric-reducing power (IC<sub>50</sub> 4018.61 ± 656.69 and A<sub>0.5 </sub>at 359.88 ±63.64 µg/mL respectively), in contrast to other antioxidant tests (ABTS, Beta-carotene and CUPRAC) where BBG demonstrated a moderate activity (IC<sub>50</sub> 529.91 ±26.37, IC<sub>50</sub> 161.013±13.322, A<sub>0.5 </sub>529.79 ± 48.65 µg/mL). The scavenging ability of hydroxyl radical and superoxide radical by BBG with an IC<sub>50</sub> at 2268.38±101.57 µg/mL and IC<sub>50</sub> 345.26± 62.32 µg/mL, respectively, while enzymatic inhibition by  BBG exhibited for AChE at IC<sub>50</sub> 859.164 ±64.46 μg/mL , BChE at IC<sub>50</sub> at 725.470 ±30.95 , α-Amylase inhibitory activity at IC<sub>50</sub> 2986.785 ± 37.046  . The bacterial growth of the two strains used in this study is favorably affected by the use of BBG as the only carbon source, in comparison with glucose as a control. In light of these findings, it can be concluded that BBG have shown moderate antioxidant and enzyme inhibitory activities and can be used as a prebiotic by acting synergistically with probiotics in functional food matrices.</p>

scholarly journals A Novel Method for the Assay of .ALPHA.-Glucosidase Inhibitory Activity Using a Multi-channel Oxygen Sensor.

2002 ◽  
Vol 18 (12) ◽  
pp. 1315-1319 ◽  
Author(s):  
Kiyoshi MATSUMOTO ◽  
Kayoko TAKEMATA ◽  
Kiyofumi TAKAYAMA ◽  
Kanthi J. M. ABESUNDARA ◽  
Toshiro MATSUI ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Oxygen Sensor ◽  
Novel Method ◽  
Alpha Glucosidase

Phenylpropanoid and Iridoid Glucosides from the Whole Plant of Hemiphragma heterophyllum and Their alpha-Glucosidase Inhibitory Activities

Planta Medica ◽  
2020 ◽  
Vol 86 (03) ◽  
pp. 205-211
Author(s):  
Yan-Hong Li ◽  
Jia-Meng Dai ◽  
Cui Yang ◽  
Meng-Yuan Jiang ◽  
Yong Xiong ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Ethanol Extract ◽  
2D Nmr ◽  
Positive Control ◽  
Iridoid Glucoside ◽  
2D Nmr Spectroscopy ◽  
Whole Plant ◽  
Ic50 Value ◽  
Iridoid Glucosides ◽  
Alpha Glucosidase

AbstractThree phenylpropanoid glucosides (1 – 3) and one iridoid glucoside (11), together with eleven known glucosides, were isolated from the ethanol extract of the whole plant of Hemiphragma heterophyllum. Their structures were elucidated by means of 1D and 2D NMR spectroscopy, HRMS, and chemical methods. All compounds except 11 and 13 – 15 showed varying degrees of α-glucosidase inhibitory activity. Compounds 5, 9, and 12 were marginally active in the bioassay, while compounds 1 – 4, 6 – 8, and 10 exhibited appreciable inhibitory activity with an IC50 value of 33.6 ~ 83.1 µM, which was much lower than that of the positive control acarbose (IC50 = 310.8 µM).

scholarly journals Effect of storage time on metabolite profile and alpha-glucosidase inhibitory activity of Cosmos caudatus leaves – GCMS based metabolomics approach

2015 ◽  
Vol 23 (3) ◽  
pp. 433-441 ◽  
Author(s):  
Neda Javadi ◽  
Faridah Abas ◽  
Ahmed Mediani ◽  
Azizah Abd Hamid ◽  
Alfi Khatib ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Storage Time ◽  
Metabolite Profile ◽  
Cosmos Caudatus ◽  
Alpha Glucosidase

Exploration of Diosmin to control diabitis and its complications-an in vitro and in silico approach

2020 ◽  
Vol 16 ◽  
Author(s):  
Kushagra Dubey ◽  
Raghvendra Dubey ◽  
Revathi Gupta ◽  
Arun Gupta
Keyword(s):  
Molecular Docking ◽  
Aldose Reductase ◽  
Inhibitory Activity ◽  
Blood Lipid ◽  
Docking Studies ◽  
Alpha Amylase ◽  
Lipid Lowering ◽  
Molecular Docking Studies ◽  
Alpha Glucosidase

Background: Diosmin is a flavonoid obtained from the citrus fruits of the plants. Diosmin has blood lipid lowering activities, antioxidant activity, enhances venous tone and microcirculation, protects capillaries, mainly by reducing systemic oxidative stress. Objective: The present study demonstrates the potential of Diosmin against the enzymes aldose reductase, α-glucosidase, and α-amylase involved in diabetes and its complications by in vitro evaluation and reverse molecular docking studies. Method: The assay of aldose reductase was performed by using NADPH as starting material and DL-Glyceraldehyde as a substrate. DNS method was used for alpha amylase inhibition and in alpha glucosidase inhibitory activity p-nitrophenyl glucopyranoside (pNPG) was used as substrate. The reverse molecular docking studies was performed by using Molegro software (MVD) with grid resolution of 30 Å. Result: Diosmin shows potent inhibitory effect against aldose reductase (IC50:333.88±0.04 µg/mL), α-glucosidase (IC50:410.3±0.01 µg/mL) and α-amylase (IC50: 404.22±0.02 µg/mL) respectively. The standard drugs shows moderate inhibitory activity for enzymes. The MolDock Score of Diosmin was -224.127 against aldose reductase, -168.17 against α-glucosidase and -176.013 against α-amylase respectively, which was much higher than standard drugs. Conclusion: From the result it was concluded that diosmin was a potentially inhibitor of aldose reductase, alpha amylase and alpha glucosidase enzymes then the standard drugs and it will be helpful in the management of diabetes and its complications. This will also be benevolent to decrease the socio economical burden on the middle class family of the society.

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