scholarly journals Alpha-Glucosidase Inhibitory Activity and Fractionation of Bioactive Compounds from bark Extracts of Sibucao (Caesalpinia sappan L.) In the Philippines

2017 ◽  
Vol 9 (3) ◽  
pp. 356-360 ◽  
Author(s):  
Ea Kristine Clarisse B. Tulin ◽  
Ma Theresa P. Loreto ◽  
Edgardo E. Tulin
Keyword(s):  
Bioactive Compounds ◽  
Inhibitory Activity ◽  
The Philippines ◽  
Caesalpinia Sappan ◽  
Alpha Glucosidase

scholarly journals Anabaenopeptins: What We Know So Far

Toxins ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 522
Author(s):  
Patrick Romano Monteiro ◽  
Samuel Cavalcante do Amaral ◽  
Andrei Santos Siqueira ◽  
Luciana Pereira Xavier ◽  
Agenor Valadares Santos
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Inhibitory Activity ◽  
Important Class ◽  
Biotechnological Applications ◽  
Peptide Synthetases ◽  
Ecological Roles ◽  
Cyclic Hexapeptides ◽  
Key Features

Cyanobacteria are microorganisms with photosynthetic mechanisms capable of colonizing several distinct environments worldwide. They can produce a vast spectrum of bioactive compounds with different properties, resulting in an improved adaptative capacity. Their richness in secondary metabolites is related to their unique and diverse metabolic apparatus, such as Non-Ribosomal Peptide Synthetases (NRPSs). One important class of peptides produced by the non-ribosomal pathway is anabaenopeptins. These cyclic hexapeptides demonstrated inhibitory activity towards phosphatases and proteases, which could be related to their toxicity and adaptiveness against zooplankters and crustaceans. Thus, this review aims to identify key features related to anabaenopeptins, including the diversity of their structure, occurrence, the biosynthetic steps for their production, ecological roles, and biotechnological applications.

scholarly journals ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITION ACTIVITY OF SELECTED EDIBLE SEAWEEDS FROM SOUTH COAST AREA OF INDIA

2017 ◽  
Vol 9 (6) ◽  
pp. 64 ◽  
Author(s):  
P. Reka ◽  
Thahira Banu A. ◽  
M. Seethalakshmi
Keyword(s):  
Aqueous Extract ◽  
Inhibitory Activity ◽  
Alpha Amylase ◽  
Postprandial Blood Glucose ◽  
Inhibition Activity ◽  
Gracilaria Edulis ◽  
Edible Seaweeds ◽  
Daily Diet ◽  
Postprandial Blood Glucose Level ◽  
Alpha Glucosidase

Objective: The present work was to investigate the alpha amylase and alpha-glucosidase inhibitory activity of the selected edible seaweeds.Methods: The seaweeds namely Acanthophora spicifera, Gracilaria corticata, Gracilaria edulis, Ulva lactuca and Ulva reticulata were selected for this study. Six and eight hours of ethanol and aqueous extract were used for the estimation of alpha amylase using DNS method and alpha-glucosidase inhibition activity.Results: The study reported that the solvent from ethanol and aqueous in eight hours of extraction showed a higher inhibitory activity than six hours of extraction. Maximum of 89.1±0.96 and 79.55±3.08 percent of alpha-amylase and alpha-glucosidase inhibition activity were detected in the eight hours of aqueous extract (0.5 ml) of Ulva reticulata and Gracilaria edulis respectively. All the selected edible seaweeds had significant differences (p<0.05) in alpha amylase and alpha glucosidase inhibition activity between the selected seaweeds with different extracts.Conclusion: It was concluded that all the selected edible seaweeds have the potential to act as a potent inhibitor of the carbohydrate hydrolyzing enzyme. Thus, it was clear from the study that seaweeds incorporated in small amounts in the dishes consumed in the daily diet can bring a control on postprandial blood glucose level.

scholarly journals Nutritional Composition and .ALPHA.-Glucosidase Inhibitory Activity of Five Chinese Vinegars

2011 ◽  
Vol 45 (4) ◽  
pp. 445-456 ◽  
Author(s):  
JunFeng FAN ◽  
YanYan ZHANG ◽  
LinNa ZHOU ◽  
ZaiGui LI ◽  
BoLin ZHANG ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Nutritional Composition ◽  
Alpha Glucosidase

scholarly journals Antioxidant, anti-cholinesterase, anti-α-glucosidase and prebiotic properties of beta-glucan extracted from Algerian barley

2018 ◽  
Vol 10 (1) ◽  
pp. 58 ◽  
Author(s):  
Saad Mebrek ◽  
Hanene Djeghim ◽  
Yamina Mehdi ◽  
Asma Meghezzi ◽  
Sirajudheen Anwar ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Reducing Power ◽  
Beta Carotene ◽  
Moderate Activity ◽  
Beta Glucan ◽  
Antioxidant Power ◽  
Camel's Milk ◽  
Therapeutic Properties ◽  
Alpha Glucosidase ◽  
Low Activity

<p>Beta-glucan, such as barley-derived beta-glucan (BBG), are homopolysaccharides that have attracted attention by their nutritional and therapeutic properties. The aim of this study was to evaluate the antioxidant power of BBG extracted from local Algerian variety of barley (SAIDA 183), and its acetylcholinesterase, alpha glucosidase inhibitory activity as well as its prebiotic potential by fermentation with lactic acid bacteria isolated from camel’s milk, namely <em>lactococcuslactisssplactis</em> (Lc.l.l) and <em>leuconostocmesenteroidesspmesenteroides</em> (Ln.m.m). The results revealed that BBG exhibited low activity against DPPH and ferric-reducing power (IC<sub>50</sub> 4018.61 ± 656.69 and A<sub>0.5 </sub>at 359.88 ±63.64 µg/mL respectively), in contrast to other antioxidant tests (ABTS, Beta-carotene and CUPRAC) where BBG demonstrated a moderate activity (IC<sub>50</sub> 529.91 ±26.37, IC<sub>50</sub> 161.013±13.322, A<sub>0.5 </sub>529.79 ± 48.65 µg/mL). The scavenging ability of hydroxyl radical and superoxide radical by BBG with an IC<sub>50</sub> at 2268.38±101.57 µg/mL and IC<sub>50</sub> 345.26± 62.32 µg/mL, respectively, while enzymatic inhibition by  BBG exhibited for AChE at IC<sub>50</sub> 859.164 ±64.46 μg/mL , BChE at IC<sub>50</sub> at 725.470 ±30.95 , α-Amylase inhibitory activity at IC<sub>50</sub> 2986.785 ± 37.046  . The bacterial growth of the two strains used in this study is favorably affected by the use of BBG as the only carbon source, in comparison with glucose as a control. In light of these findings, it can be concluded that BBG have shown moderate antioxidant and enzyme inhibitory activities and can be used as a prebiotic by acting synergistically with probiotics in functional food matrices.</p>

scholarly journals Bioactive Compounds and Antioxidative, Antileukemic and Anti-MMPs Activity of Eleutherococcus Species Cultivated in Poland

2012 ◽  
Vol 7 (11) ◽  
pp. 1934578X1200701
Author(s):  
Daniel Załuski ◽  
Helena D. Smolarz ◽  
Urszula Gawlik-Dziki
Keyword(s):  
Biological Activity ◽  
Cell Line ◽  
Bioactive Compounds ◽  
Inhibitory Activity ◽  
Ethanolic Extract ◽  
Apoptotic Cells ◽  
Biological Studies ◽  
Dpph Activity ◽  
Leaves And Roots

The content of phenols (TPC), and the antioxidative, antileukemic and anti-MMPs properties of Eleutherococcus spp. cultivated in Poland are reported. The highest TPC was found in the spring leaves (20.3 – 37.2 mg/g). The spring leaves and roots of E. divaricatus had the strongest anti-DPPH activity (EC50 1.2 and 1.2 mg/mL), whereas the greatest ability of iron (II) chelating was shown by autumn leaves of E. setchuensis (EC50 0.3 mg/mL), and the ethanolic extract of E. gracilistylus roots showed the strongest lipid antiperoxidation activity (EC50 0.7 mg/mL). The highest number of apoptotic cells was observed in the Jurkat 45 cell line after treatment with the ethanolic extract of E. sessiliflorus roots (27%). Only the chloroform extracts of roots of E. gracilistylus and E. divaricatus showed the inhibitory activity against MMPs. Most of the studied species have a significant biological activity that is probably due to the presence of phenols. To the best of our knowledge, neither detailed phytochemical nor biological studies have been performed for most of the investigated species.

scholarly journals LOWERING URIC ACID EFFICACY TEST OF THE COMBINED EXTRACT OF UNCARIA GAMBIR (HUNTER) ROXB. AND CAESALPINIA SAPPAN L. IN VIVO AND IN VITRO

2018 ◽  
Vol 11 (8) ◽  
pp. 166
Author(s):  
Sri Ningsih ◽  
Fahri Fahrudin
Keyword(s):  
Antioxidant Activity ◽  
Uric Acid ◽  
Inhibitory Activity ◽  
Positive Control ◽  
Polyphenol Content ◽  
Caesalpinia Sappan ◽  
In Vivo Experiments ◽  
A Value

 Objective: Hyperuricemia (high uric acid levels) prevalence increased year by year. This study was aimed to elaborate the in vitro xanthine oxidase (XO) inhibitory activity and in vivo lowering hyperuricemic effect of Uncaria gambir (Hunter) Roxb) (gambir), Caesalpinia sappan L. (secang) and the combined extract of secang and gambir (formulae extract [FE]).Methods: Gambir and secang extracts were prepared by maceration with ethanol and FE was the proportioned combination of these two extracts. XO inhibitory activity was determined by measuring the formation of uric acid in the xanthine/XO system in vitro using allopurinol as a positive control at 100 ug/mL. Antioxidant activity was by 1,1-diphenyl-2-picrylhydrazyl radical reducing methods. The in vivo experiments were conducted in the oxonate-induced hyperuricemia rat model, in which FE was gavaged p.o. at the arrange dose of 75, 150, and 300 mg/kg bw for 2 weeks. Polyphenol content was measured using Folin–Ciocalteu reagent spectrophotometrically.Results: The XO inhibitory activity of FE was 80% of allopurinol, while secang and gambir were 98% and 50%, respectively. The strength was appropriate to the total polyphenol content, in which it decreased in the order of secang (99%) > FE (86%) > gambir (46%). Furthermore, FE at all tested doses was able to decrease uric acid levels. FE also demonstrated antioxidant activity with a value of 74% relative to Vitamin C at 4 ug/mL.Conclusion: These studies could be concluded that FE exhibited the ability to decrease uric acid level so that it was potential to be developed further as a uric acid-lowering agent.

Identification of bioactive compounds that contribute to the α-glucosidase inhibitory activity of rosemary

2020 ◽  
Vol 11 (2) ◽  
pp. 1692-1701
Author(s):  
Yan-Yan Ma ◽  
Deng-Gao Zhao ◽  
Ruiqiang Zhang ◽  
Xuan He ◽  
Bao Qiong Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Bioactive Compounds ◽  
Inhibitory Activity ◽  
Enzyme Assay ◽  
Triterpene Acids ◽  
Orbitrap Mass Spectrometry

To investigate the bioactive compounds that contribute to the α-glucosidase inhibitory activity of rosemary, phenolics and triterpene acids were characterized and quantified using quadrupole-Orbitrap mass spectrometry and enzyme assay.

Sign in / Sign up

Export Citation Format

Share Document