scholarly journals Physicochemical characterization of spray dried cefixime polymeric nanoparticles using factorial design approach

2016 ◽  
pp. 124-132 ◽  
Author(s):  
Pooja Desai ◽  
Yogesh Pore
Keyword(s):  
Factorial Design ◽  
Polymeric Nanoparticles ◽  
Physicochemical Characterization ◽  
Design Approach ◽  
Spray Dried

scholarly journals Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols

2016 ◽  
Vol Volume 10 ◽  
pp. 4017-4030 ◽  
Author(s):  
Hyo-Jung Lee ◽  
Ji-Hyun Kang ◽  
Hong-Goo Lee ◽  
Dong-Wook Kim ◽  
Yun-Seok Rhee ◽  
...  
Keyword(s):  
Physicochemical Characterization ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Spray Dried

Physicochemical Characterization of Spray-Dried Phenylbutazone Polymorphs

1984 ◽  
Vol 73 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Yoshihisa Matsuda ◽  
Sachiyo Kawaguchi ◽  
Hitomi Kobayashi ◽  
Jujiro Nishijo
Keyword(s):  
Physicochemical Characterization ◽  
Spray Dried

scholarly journals Protein hydrolysate of mechanically separated meat from Nile tilápia

2020 ◽  
Vol 55 ◽  
Author(s):  
Cassandra Meireles Terres-Ribeiro ◽  
André Marcelo Knak ◽  
Rosana Aparecida da Silva Buzanello ◽  
Denise Pastore de Lima ◽  
Roberto Montanhini Neto ◽  
...  
Keyword(s):  
Water Activity ◽  
Protein Hydrolysate ◽  
Physicochemical Characterization ◽  
Essential Amino Acids ◽  
Drying Methods ◽  
Prominent Component ◽  
Freeze Dried ◽  
Mechanically Separated Meat ◽  
Spray Dried

Abstract: The objective of this work was to enzymatically obtain hydrolysate tilapia protein powder by two drying methods, and to perform a physicochemical characterization of the final products, as well as to evaluate their thermal stability. Proximal composition, aminogram, fatty acid profile, pH, color, water activity, and microbiological analyses were performed. Crude protein was the prominent component, with 87% in the spray-dried powder and 89% in the lyophilized powder, showing no statistical difference. The samples showed no bacterial growth, which may be associated with the low water activity in the products. Dry samples had b* positive, and the freeze-dried ones were more yellowish than the spray-dried ones. Both drying methods promoted similar luminosity near the white color. In the thermal analysis, samples showed 26% mass loss at 200°C, and degradation started at 290°C. Enzymatic hydrolysis is efficient, and the hydrolysate tilapia protein powder contains all essential amino acids. The hydrolysate shows similar protein content for both spray-dried and freeze-dried samples, and the final products are stable at high temperatures.

scholarly journals Optimized Preparation of Levofloxacin Loaded Polymeric Nanoparticles

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 57 ◽  
Author(s):  
Manuel López-López ◽  
Angela Fernández-Delgado ◽  
María Moyá ◽  
Daniel Blanco-Arévalo ◽  
Cecilio Carrera ◽  
...  
Keyword(s):  
Organic Solvent ◽  
Polymeric Nanoparticles ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Antimicrobial Activities ◽  
Plga Nanoparticles ◽  
Time Period ◽  
Vitro Release

In this work, poly(lactic-co-glycolic acid) (PLGA) and chitosan (CS) nanoparticles were synthesized with the purpose of encapsulating levofloxacin (LEV). A thorough study has been carried out in order to optimize the preparation of LEV-loaded polymeric nanoparticles (NPs) suitable for parenteral administration. Changes in the preparation method, in the organic solvent nature, in the pH of the aqueous phase, or in the temperature were investigated. To the authors´ knowledge, a systematic study in order to improve the LEV nanocarrier characteristics and the yield of drug encapsulation has not been carried out to date. The physicochemical characterization of the NPs, their encapsulation efficiency (EE), and the in vitro release of LEV revealed that the best formulation was the emulsion-solvent evaporation method using dichloromethane as organic solvent, which renders suitable LEV loaded PLGA NPs. The morphology of these NPs was investigated using TEM. Their antimicrobial activities against several microorganisms were determined in vitro measuring the minimum inhibitory concentration (MIC). The results show that the use of these loaded LEV PLGA nanoparticles has the advantage of the slow release of the antibiotic, which would permit an increase in the time period between administrations as well as to decrease the side effects of the drug.

Physicochemical characterization of spray dried ternary micro-complexes of cefuroxime axetil with hydroxypropyl-β-cyclodextrin

2012 ◽  
Vol 76 (3-4) ◽  
pp. 391-401 ◽  
Author(s):  
Manali Shah ◽  
Yogesh Pore ◽  
Shashikant Dhawale ◽  
Kishorkumar Burade ◽  
Bhanudas Kuchekar
Keyword(s):  
Physicochemical Characterization ◽  
Cefuroxime Axetil ◽  
Spray Dried
Sign in / Sign up

Export Citation Format

Share Document