scholarly journals Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols

2016 ◽  
Vol Volume 10 ◽  
pp. 4017-4030 ◽  
Author(s):  
Hyo-Jung Lee ◽  
Ji-Hyun Kang ◽  
Hong-Goo Lee ◽  
Dong-Wook Kim ◽  
Yun-Seok Rhee ◽  
...  
Keyword(s):  
Physicochemical Characterization ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Spray Dried

scholarly journals Preparation and Characterization of Celecoxib Agglomerated Nanocrystals and Dry Powder Inhalation Formulations to Improve its Aerosolization Performance

2017 ◽  
Vol 23 (4) ◽  
pp. 278-284
Author(s):  
Sepideh Mardani ◽  
Maryam Maghsoodi ◽  
Saeed Ghanbarzadeh ◽  
Ali Nokhodchi ◽  
Shadi Yaqoubi ◽  
...  
Keyword(s):  
Dry Powder Inhalation ◽  
Dry Powder

scholarly journals Development of High Dose Oseltamivir Phosphate Dry Powder for Inhalation Therapy in Viral Pneumonia

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1154
Author(s):  
Shahir Aziz ◽  
Regina Scherlieβ ◽  
Hartwig Steckel
Keyword(s):  
Virus Disease ◽  
Antiviral Drug ◽  
Physicochemical Characterization ◽  
Inhalation Therapy ◽  
High Dose ◽  
Dry Powder ◽  
Medium Resistance ◽  
High Doses ◽  
Oseltamivir Phosphate

Oseltamivir phosphate (OP) is an antiviral drug available only as oral therapy for the treatment of influenza and as a potential treatment option when in combination with other medication in the fight against the corona virus disease (COVID-19) pneumonia. In this study, OP was formulated as a dry powder for inhalation, which allows drug targeting to the site of action and potentially reduces the dose, aiming a more efficient therapy. Binary formulations were based on micronized excipient particles acting like diluents, which were blended with the drug OP. Different excipient types, excipient ratios, and excipient size distributions were prepared and examined. To investigate the feasibility of delivering high doses of OP in a single dose, 1:1, 1:3, and 3:1 drug/diluent blending ratios have been prepared. Subsequently, the aerosolization performance was evaluated for all prepared formulations by cascade impaction using a novel medium-resistance capsule-based inhaler (UNI-Haler). Formulations with micronized trehalose showed relatively excellent aerosolization performance with highest fine-particle doses in comparison to examined lactose, mannitol, and glucose under similar conditions. Focusing on the trehalose-based dry-powder inhalers’ (DPIs) formulations, a physicochemical characterization of extra micronized grade trehalose in relation to the achieved performance in dispersing OP was performed. Additionally, an early indication of inhaled OP safety on lung cells was noted by the viability MTT assay utilizing Calu-3 cells.

scholarly journals Development of an Innovative, Carrier-Based Dry Powder Inhalation Formulation Containing Spray-Dried Meloxicam Potassium to Improve the In Vitro and In Silico Aerodynamic Properties

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 535 ◽  
Author(s):  
Edit Benke ◽  
Árpád Farkas ◽  
Piroska Szabó-Révész ◽  
Rita Ambrus
Keyword(s):  
In Silico ◽  
Chronic Obstructive ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Aerodynamic Properties ◽  
Drug Concentrations ◽  
Anti Inflammatory ◽  
New Formulation ◽  
Spray Dried

Most of the marketed dry powder inhalation (DPI) products are traditional, carrier-based formulations with low drug concentrations deposited in the lung. However, due to their advantageous properties, their development has become justified. In our present work, we developed an innovative, carrier-based DPI system, which is an interactive physical blend of a surface-modified carrier and a spray-dried drug with suitable shape and size for pulmonary application. Meloxicam potassium, a nonsteroidal anti-inflammatory drug (NSAID), was used as an active ingredient due to its local anti-inflammatory effect and ability to decrease the progression of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The results of the in vitro and in silico investigations showed high lung deposition in the case of this new formulation, confirming that the interparticle interactions were changed favorably.

Physicochemical Characterization of Spray-Dried Phenylbutazone Polymorphs

1984 ◽  
Vol 73 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Yoshihisa Matsuda ◽  
Sachiyo Kawaguchi ◽  
Hitomi Kobayashi ◽  
Jujiro Nishijo
Keyword(s):  
Physicochemical Characterization ◽  
Spray Dried

scholarly journals Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 427
Author(s):  
Priya Muralidharan ◽  
Maria F. Acosta ◽  
Alexan I. Gomez ◽  
Carissa Grijalva ◽  
Haiyang Tang ◽  
...  
Keyword(s):  
Human Lung ◽  
Antioxidant Properties ◽  
Dry Powder Inhaler ◽  
Chinese Herbs ◽  
Dry Powder ◽  
Comprehensive Characterization ◽  
Spray Dried

This is the first study reporting on the design and development innovative inhaled formulations of the novel natural product antioxidant therapeutic, tetramethylpyrazine (TMP), also known as ligustrazine. TMP is obtained from Chinese herbs belonging to the class of Ligusticum. It is known to have antioxidant properties. It can act as a Nrf2/ARE activator and a Rho/ROCK inhibitor. The present study reports for the first time on the comprehensive characterization of raw TMP (non-spray dried) and spray dried TMP in a systematic manner using thermal analysis, electron microscopy, optical microscopy, and Raman spectroscopy. The in vitro aerosol dispersion performance of spray dried TMP was tested using three different FDA-approved unit-dose capsule-based human dry powder inhaler devices. In vitro human cellular studies were conducted on pulmonary cells from different regions of the human lung to examine the biocompatibility and non-cytotoxicity of TMP. Furthermore, the efficacy of inhaled TMP as both liquid and dry powder inhalation aerosols was tested in vivo using the monocrotaline (MCT)-induced PH rat model.

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