scholarly journals Design and evaluation of liposomal delivery system for L-Asparaginese

Author(s):  
Anindita
2018 ◽  
Vol Volume 13 ◽  
pp. 763-776 ◽  
Author(s):  
Xiao-qian Dou ◽  
Hua Wang ◽  
Jing Zhang ◽  
Fang Wang ◽  
Gui-li Xu ◽  
...  

2021 ◽  
Vol 27 ◽  
Author(s):  
Bapi Gorain ◽  
Bandar E. Al-Dhubiab ◽  
Anroop Nair ◽  
Prashant Kesharwani ◽  
Manisha Pandey ◽  
...  

: The advancement of delivery tools for therapeutic agents has brought several novel formulations with increased drug loading, sustained release, targeted delivery, and prolonged efficacy. Amongst the several novel delivery approaches, multivesicular liposome has gained potential interest because this delivery system possesses the above advantages. In addition, this multivesicular liposomal delivery prevents degradation of the entrapped drug within the physiological environment while administered. The special structure of the vesicles allowed successful entrapment of hydrophobic and hydrophilic therapeutic agents, including proteins and peptides. Furthermore, this novel formulation could maintain the desired drug concentration in the plasma for a prolonged period, which helps to reduce the dosing frequencies, improve bioavailability, and safety. This tool could also provide stability of the formulation, and finally gaining patient compliance. Several multivesicular liposomes received approval for clinical research, while others are at different stages of laboratory research. In this review, we have focused on the preparation of multivesicular liposomes along with their application in different ailments for the improvement of the performance of the entrapped drug. Moreover, the challenges of delivering multivesicular vesicles have also been emphasized. Overall, it could be inferred that multivesicular liposomal delivery is a novel platform of advanced drug delivery with improved efficacy and safety.


1997 ◽  
Vol 83 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Meng-Feng Shieh ◽  
I-Ming Chu ◽  
Chau-Jen Lee ◽  
Pei Kan ◽  
Dou-Mong Hau ◽  
...  

2012 ◽  
Vol 101 (2) ◽  
pp. 598-609 ◽  
Author(s):  
Purusotam Basnet ◽  
Haider Hussain ◽  
Ingunn Tho ◽  
Natasa Skalko-Basnet

Author(s):  
SINGH . ARPITA ◽  
SRIVASTAVA VIKAS KUMAR ◽  
GUPTA AMRESH

The function of belayed vesicles as productive transporters for drugs, immunizations, indicative specialists, and other bioactive operators has prompted a fast headway in the liposomal drug conveyance system. The pharmacy- elements and pharmacokinetics properties are altered for the liposomal delivery system,which on thewholeleads to an increased the rapeutic index with decreased toxicity. The liposome can be named multilamellar vesicles or unilamellar vesicles, which can be additionally named large unilamellar vesicles (LUV) or small unilamellar vesicles (SUV). The part of liposome as a medication conveyance framework is to convey drug in a controlled way, diminishing unfortunate reactions improving it is in vitro and in vivo action, just as lessening the harmfulness of the medication and upgrading the viability of the exemplified drug. This article gives a review of techniques to the planning of liposome, just as diagnostic strategies for control physical, concoction, and organic boundaries for various kinds of medications.


2004 ◽  
Vol 6 (4) ◽  
pp. 13-22 ◽  
Author(s):  
Siddhesh D. Patil ◽  
David G. Rhodes ◽  
Diane J. Burgess

1992 ◽  
Vol 18 (3) ◽  
pp. 303-317 ◽  
Author(s):  
M. Akbarieh ◽  
J. G. Besner ◽  
A. Galal ◽  
R. Tawashi

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