scholarly journals Effective mucoadhesive liposomal delivery system for risedronate: preparation and in vitro/in vivo characterization

2014 ◽  
pp. 2299 ◽  
Author(s):  
Hyo-Kyung Han ◽  
Il-Woo Jung ◽  
Beom-Jin Lee
Keyword(s):  
Delivery System ◽  
Liposomal Delivery ◽  
In Vivo Characterization

LIPOSOMES – A REVIEW

2020 ◽  
pp. 1-6
Author(s):  
SINGH . ARPITA ◽  
SRIVASTAVA VIKAS KUMAR ◽  
GUPTA AMRESH
Keyword(s):  
Delivery System ◽  
Unilamellar Vesicles ◽  
Multilamellar Vesicles ◽  
Liposomal Drug ◽  
Diagnostic Strategies ◽  
Large Unilamellar Vesicles ◽  
Small Unilamellar Vesicles ◽  
Liposomal Delivery

The function of belayed vesicles as productive transporters for drugs, immunizations, indicative specialists, and other bioactive operators has prompted a fast headway in the liposomal drug conveyance system. The pharmacy- elements and pharmacokinetics properties are altered for the liposomal delivery system,which on thewholeleads to an increased the rapeutic index with decreased toxicity. The liposome can be named multilamellar vesicles or unilamellar vesicles, which can be additionally named large unilamellar vesicles (LUV) or small unilamellar vesicles (SUV). The part of liposome as a medication conveyance framework is to convey drug in a controlled way, diminishing unfortunate reactions improving it is in vitro and in vivo action, just as lessening the harmfulness of the medication and upgrading the viability of the exemplified drug. This article gives a review of techniques to the planning of liposome, just as diagnostic strategies for control physical, concoction, and organic boundaries for various kinds of medications.

scholarly journals Systemic Administration of miRNA Mimics by Liposomal Delivery System in Animal Model of Colorectal Carcinoma

2016 ◽  
pp. S481-S488 ◽  
Author(s):  
J. MERHAUTOVÁ ◽  
P. VYCHYTILOVÁ-FALTEJSKOVÁ ◽  
R. DEMLOVÁ ◽  
O. SLABÝ
Keyword(s):  
Delivery System ◽  
Tumor Volume ◽  
Human Cancer ◽  
Suppressive Effect ◽  
Systemic Administration ◽  
In Vivo Experiments ◽  
Nsg Mice ◽  
Liposomal Delivery

MiRNAs are important regulators of gene expression and changes in their levels are linked with various pathological states, including solid tumors. MiR-215 has been identified as a tumor suppressor in colorectal cancer (CRC). Following our previous in vitro and in vivo experiments, the aim of this project was to study the possibility of increasing the levels of miR-215 in tumor cells by systemic administration of miRNA mimics in liposomal delivery system in vivo. By subcutaneous xenotransplantation of human cancer cells to NSG mice, CRC model was established. The treatment [miR-215 mimics in liposomes (20 and 40 μg/mouse), control oligonucleotide in liposomes, or saline] was administered repeatedly by i.v. injection via tail-vein. Animals were sacrificed, tumor were dissected and measured by a caliper. Expression of miR-215 in tumors, lungs and liver was quantified by RT-PCR. There was no significant differences in tumor volume and miR-215 expression between all three treatment groups. Therefore, the decrease in tumor volume was not achieved. By comparing the levels of miR-215 in lungs, liver and tumors after the treatment, we suggest that the liposomes are accumulated in the lungs and do not concentrate sufficiently in the tumor site to exert significant tumor-suppressive effect.

Self-nanoemulsifying drug delivery system of docosahexanoic acid: development, in vitro, in vivo characterization

2015 ◽  
Vol 42 (7) ◽  
pp. 1032-1041 ◽  
Author(s):  
Ritika Puri ◽  
Mohit Mahajan ◽  
Nikhil Shri Sahajpal ◽  
Harjeet Singh ◽  
Harmanpreet Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Docosahexanoic Acid ◽  
Development In Vitro ◽  
In Vivo Characterization

In-vitro and in-vivo characterization of a buprenorphine delivery system

2006 ◽  
Vol 58 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Sofie R. Kleppner ◽  
Raj Patel ◽  
Lauren C. Costantini ◽  
Joseph McDonough
Keyword(s):  
Delivery System ◽  
In Vivo Characterization
Sign in / Sign up

Export Citation Format

Share Document