scholarly journals Poly(L-glutamic acid) Microsphere: Preparation and Application in Oral Drug Controlled Release

2015 ◽  
Vol 73 (1) ◽  
pp. 60 ◽  
Author(s):  
Li Zhao ◽  
Jianxun Ding ◽  
Chunsheng Xiao ◽  
Xuesi Chen ◽  
Guangqing Gai ◽  
...  
Keyword(s):  
Controlled Release ◽  
Glutamic Acid ◽  
Oral Drug ◽  
Drug Controlled Release ◽  
Microsphere Preparation

scholarly journals Nano-Carriers Based on pH-Sensitive Star-Shaped Copolymers for Drug-Controlled Release

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1610 ◽  
Author(s):  
Wenzhao Jiang ◽  
Jianwei Guo ◽  
Weiqiu Wen ◽  
Yong-Guang Jia ◽  
Sa Liu
Keyword(s):  
Controlled Release ◽  
In Vitro Release ◽  
Chemical Properties ◽  
In Vitro Cytotoxicity ◽  
Ph Sensitive ◽  
Oral Drug ◽  
Time Interval ◽  
Selective Hydrolysis ◽  
Drug Controlled Release

Polymeric nano-carriers are considered as promising tools in biomedical applications due to multiple attractive characteristics including their low toxicity, high loading capacity, controlled drug release capabilities, and highly tunable chemical properties. Here, a series of pH-sensitive star-shaped copolymers, Ad-P[(EMA-co-MAA)-b-PPEGMA]4, was prepared via electron transfer atom radical polymerization (ARGETE ATRP) and selective hydrolysis. These star-shaped copolymers can be self-assembled into micelles (Dh = 150–160 nm) and their critical micelle concentrations (CMC) were estimated to be 3.9–5.0 mg/L. The pH-sensitiveness of the micelles was evidenced by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The maximal paclitaxel (PTX) loading efficiency (DLC) and entrapment efficiency (EE) were 18.9% and 36%, respectively. In vitro release studies revealed that about 19% of the PTX released at an acidic condition of pH 1.2 over 70 h, whereas more than 70% was released within the same time interval at pH 6.8. In vitro cytotoxicity suggested that the low cytotoxicity of the blank micelles, while the PTX-loaded micelles providing the cytotoxicity close to that of free PTX. These results indicated that this novel pH-sensitive nano-carriers have great potential applications for oral drug-controlled release.

Antibiotic-anionic Clay Matrix Used for Drug Controlled Release

2018 ◽  
Vol 69 (2) ◽  
pp. 321-323
Author(s):  
Georgeta Zegan ◽  
Elena Mihaela Carausu ◽  
Loredana Golovcencu ◽  
Alina Sodor Botezatu ◽  
Eduard Radu Cernei ◽  
...  
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxides ◽  
Bioactive Molecules ◽  
Drug Controlled Release ◽  
Anionic Clays ◽  
Anionic Clay ◽  
Toxicological Studies ◽  
High Efficient ◽  
Clay Matrix ◽  
Double Hydroxides

Anionic clay matrix acting as drug controlled release system have shown in last years a great potential for delivery of bioactive molecules and chemical therapeutics. This organic-inorganic nanohybrid system is high efficient offering an excellent protection of intercalated compounds from degradation. Compared to other nanoparticles used in medical area, anionic clays type layered double hydroxides have found to be biocompatible according to toxicological studies. Ampicillin containing MgAlLDHs and ZnAlLDH samples have been prepared following two routes: anion-exchange procedure and reconstruction from calcined layered double hydroxides. Solid samples have been characterized by FTIR and SEM-EDX highlighting the alteration of pristine LDHs structure when the antibiotic is introduced in the interlayer gallery.

Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (l-glutamic acid)-based microgels for oral insulin controlled release

2012 ◽  
Vol 89 (4) ◽  
pp. 1207-1214 ◽  
Author(s):  
Yunyan Bai ◽  
Zhe Zhang ◽  
Aiping Zhang ◽  
Li Chen ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Controlled Release ◽  
Glutamic Acid ◽  
Hydroxypropyl Cellulose ◽  
Oral Insulin ◽  
Ph Responsive

Behaviour Of Different Silica-Based Mesoporous As Matrixes For Drug Controlled Release

2010 ◽  
pp. 7-16
Author(s):  
Rosario Aiello ◽  
Ida Stefania Carino ◽  
Francesca Iemma ◽  
Luigi Pasqua ◽  
Francesco Puoci ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Controlled Release

scholarly journals Contact lenses as drug controlled release systems: a narrative review

2016 ◽  
Vol 75 ◽  
Author(s):  
Helena Prior Filipe ◽  
José Henriques ◽  
Pedro Reis ◽  
Pedro Cruz Silva ◽  
Maria João Quadrado ◽  
...  
Keyword(s):  
Controlled Release ◽  
Contact Lenses ◽  
Narrative Review ◽  
Drug Controlled Release

Investigation of magnetic silica with thermoresponsive chitosan coating for drug controlled release and magnetic hyperthermia application

2019 ◽  
Vol 97 ◽  
pp. 23-30 ◽  
Author(s):  
Weeraphat Pon-On ◽  
Tanatsaparn Tithito ◽  
Weerakanya Maneeprakorn ◽  
Tanapon Phenrat ◽  
I-Ming Tang
Keyword(s):  
Controlled Release ◽  
Magnetic Hyperthermia ◽  
Drug Controlled Release ◽  
Chitosan Coating ◽  
Magnetic Silica
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