Assessing the history and value of Human Genome Sciences

2013 ◽  
Vol 19 (4) ◽  
Author(s):  
Laura M. McNamee ◽  
Fred D Ledley
Keyword(s):  
Human Genome ◽  
Business Plan ◽  
Market Potential ◽  
Translational Science ◽  
Capital Investments ◽  
Present Value ◽  
Total Capital ◽  
History Of ◽  
Highly Correlated ◽  
Over Time

Human Genome Science (HGS) aspired to dominate the emergent field of genomics by discovering expressed gene sequences and developing therapeutic and diagnostic products based on proprietary genes. While HGS’ accomplishments fell short of their own lofty expectations, by the time HGS was acquired by GlaxoSmithKline, the company had extensive intellectual property and had launched a product with >$1 billion market potential. Nevertheless, HGS’ acquisition price was less than the total capital investments in the company. This work examines HGS’ history and accomplishments in the context of the business plan described by the company at their IPO. We focus specifically on the company’s valuation over time, which was highly correlated with general market indices, but negatively correlated with metrics of technical or clinical progress. The history of HGS points to the challenge of accounting for the value created by a science-based business plan. Earnings-based metrics, present value calculations, and “fair value” assessments did not account for HGS’ progress in executing their stated business plan. This work highlights the critical need for accounting practices that credit value to the progress of translational science and enable investors to profit from such investments.

scholarly journals Accumulated neighbourhood deprivation and coronary heart disease: a nationwide cohort study from Sweden

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e029248
Author(s):  
Sara Larsson Lönn ◽  
Olle Melander ◽  
Casey Crump ◽  
Kristina Sundquist
Keyword(s):  
Coronary Heart Disease ◽  
Cohort Study ◽  
Heart Disease ◽  
Single Point ◽  
Neighbourhood Deprivation ◽  
Age Cohorts ◽  
Chd Risk ◽  
History Of ◽  
Highly Correlated ◽  
Over Time

ObjectiveNeighbourhood deprivation is a recognised predictor of coronary heart disease (CHD). The overall aim was to investigate if accumulated exposure to neighbourhood deprivation resulted in higher odds of CHD.DesignThis is a longitudinal cohort study. Models based on repeated assessments of neighbourhood deprivation as well as single-point-in-time assessments were compared.SettingSweden.Participants3 140 657 Swedish men and women without a history of CHD and who had neighbourhood deprivation exposure data over the past 15 years.Primary outcome measuresCHD within 5 years’ follow-up.ResultsThe results suggested a gradient of stronger association with CHD risk by longer cumulative exposures to neighbourhood deprivation, particularly in the younger age cohorts. Neighbourhood deprivation was also highly correlated over time, especially in older age cohorts.ConclusionsThe effect of neighbourhood deprivation on CHD might depend on age. Accounting for individuals’ baseline age may therefore be important for understanding neighbourhood environmental effects on the development of CHD over time. However, because of high correlation of neighbourhood deprivation over time, single-point-in-time assessments may be adequate for CHD risk prediction especially in older adults.

The Path of Standard Albanian Language Formation

2018 ◽  
Vol 5 (2) ◽  
pp. 106-115
Author(s):  
Sindorela Doli Kryeziu
Keyword(s):  
Single Unit ◽  
Cultural Factors ◽  
Language History ◽  
Whole Process ◽  
History Of ◽  
Social And Cultural Factors ◽  
Cultural Body ◽  
Over Time ◽  
Language Literature

Abstract In our paper we will talk about the whole process of standardization of the Albanian language, where it has gone through a long historical route, for almost a century.When talking about standard Albanian language history and according to Albanian language literature, it is often thought that the Albanian language was standardized in the Albanian Language Orthography Congress, held in Tirana in 1972, or after the publication of the Orthographic Rules (which was a project at that time) of 1967 and the decisions of the Linguistic Conference, a conference of great importance that took place in Pristina, in 1968. All of these have influenced chronologically during a very difficult historical journey, until the standardization of the Albanian language.Considering a slightly wider and more complex view than what is often presented in Albanian language literature, we will try to describe the path (history) of the standard Albanian formation under the influence of many historical, political, social and cultural factors that are known in the history of the Albanian people. These factors have contributed to the formation of a common state, which would have, over time, a common standard language.It is fair to think that "all activity in the development of writing and the Albanian language, in the field of standardization and linguistic planning, should be seen as a single unit of Albanian culture, of course with frequent manifestations of specific polycentric organization, either because of divisions within the cultural body itself, or because of the external imposition"(Rexhep Ismajli," In Language and for Language ", Dukagjini, Peja, 1998, pp. 15-18.)

Transocean and the History of Tax Inversions

2018 ◽  
Vol 34 (1) ◽  
pp. 1-12
Author(s):  
Susan M. Albring ◽  
Randal J. Elder ◽  
Mitchell A. Franklin
Keyword(s):  
Multinational Corporations ◽  
Economic Impacts ◽  
Income Taxes ◽  
Tax Rates ◽  
Corporate Tax ◽  
Corporate Income Taxes ◽  
History Of ◽  
Jobs Act ◽  
The U.S ◽  
Over Time

ABSTRACT The first tax inversion in 1983 was followed by small waves of subsequent inversion activity, including two inversions completed by Transocean. Significant media and political attention focused on transactions made by U.S. multinational corporations that were primarily designed to reduce U.S. corporate income taxes. As a result, the U.S. government took several actions to limit inversion activity. The Tax Cuts and Jobs Act of 2017 (TCJA) significantly lowered U.S. corporate tax rates and one expected impact of TCJA is a reduction of inversion activity. Students use the Transocean inversions to understand the reasons why companies complete a tax inversion and how the U.S. tax code affects inversion activity. Students also learn about the structure of inversion transactions and how they have changed over time as the U.S. government attempted to limit them. Students also assess the tax and economic impacts of inversion transactions to evaluate tax policy.

Historical Representations and Recent Changes

2018 ◽  
Author(s):  
Jürgen Schaflechner
Keyword(s):  
Comparative Analysis ◽  
South Asia ◽  
Oral Histories ◽  
Detailed History ◽  
Modern Times ◽  
History Of ◽  
Historical Representations ◽  
The Rich ◽  
Many Sources ◽  
Over Time

Chapter 3 introduces the tradition of ritual journeys and sacred geographies in South Asia, then hones in on a detailed history of the grueling and elaborate pilgrimage attached to the shrine of Hinglaj. Before the construction of the Makran Coastal Highway the journey to the Goddess’s remote abode in the desert of Balochistan frequently presented a lethally dangerous undertaking for her devotees, the hardships of which have been described by many sources in Bengali, Gujarati, Hindi, Sindhi, and Urdu. This chapter draws heavily from original sources, including travelogues and novels, which are supplanted with local oral histories in order to weave a historical tapestry that displays the rich array of practices and beliefs surrounding the pilgrimage and how they have changed over time. The comparative analysis demonstrates how certain motifs, such as austerity (Skt. tapasyā), remain important themes within the whole Hinglaj genre even in modern times while others have been lost in the contemporary era.

Introduction

2018 ◽  
Author(s):  
Marko Geslani
Keyword(s):  
Comparative Study ◽  
Royal Power ◽  
History Of ◽  
Historical Developments ◽  
The Comparative Study ◽  
The Relationship ◽  
Over Time ◽  
Indian Religion

The introduction reviews the historiographic problem of the relation between fire sacrifice (yajña) and image worship (pūjā), which have traditionally been seen as opposing ritual structures serving to undergird the distinction of “Vedic” and “Hindu.” Against such an icono- and theocentric approach, it proposes a history of the priesthood in relation to royal power, centering on the relationship between the royal chaplain (purohita) and astrologer (sāṃvatsara) as a crucial, unexplored development in early Indian religion. In order to capture these historical developments, it outlines a method for the comparative study of ritual forms over time.

The Growth of Historical Method in Tang China

2018 ◽  
Author(s):  
Charles Hartman ◽  
Anthony DeBlasi
Keyword(s):  
Eleventh Century ◽  
Seventh Century ◽  
Daily Production ◽  
Successor State ◽  
Historical Method ◽  
Official History ◽  
History Of ◽  
Over Time

This chapter discusses how the full emergence of the centralized, aristocratic state in the seventh century brought about an official historiography that was part of the bureaucracy of that state. Beginning in the Tang, each dynastic court maintained an office of historiography. Over time, a regularized process evolved that, in theory and often in reality, turned the daily production of court bureaucratic documents into an official history of the dynasty. Although this process was ongoing throughout the dynasty, the final, standard ‘dynastic history’ was usually completed after the dynasty's demise by its successor state. Indeed, the very concept of a series of dynastic histories that, taken together, would present an official history of successive, legitimate Chinese states, dates from the eleventh century.

scholarly journals TIME THROUGH TIME: ITS EVOLUTION THROUGH WESTERN PHILOSOPHY IN SEVEN IDEAS

Think ◽  
2021 ◽  
Vol 20 (58) ◽  
pp. 23-38
Author(s):  
Emily Thomas
Keyword(s):  
Western Philosophy ◽  
The World ◽  
History Of ◽  
Over Time

ABSTRACTWhat is time? Just like everything else in the world, our understanding of time has changed continually over time. This article tracks this question through the history of Western philosophy and looks at major answers from the likes of Aristotle, Kant, and McTaggart.

Anterior approach levator plication for congenital ptosis, absorpable versus non absorpable sutures

2021 ◽  
pp. 112067212110053
Author(s):  
Moustafa Salamah ◽  
Ashraf Mahrous Eid ◽  
Hani Albialy ◽  
Sherif Sharaf EL Deen
Keyword(s):  
Randomized Study ◽  
Early Postoperative Period ◽  
Polyglactin 910 ◽  
Exclusion Criteria ◽  
Congenital Ptosis ◽  
History Of ◽  
Group A ◽  
Group B ◽  
Over Time

Purpose: To compare the efficacy of two different suture types in levator plication for correction of congenital ptosis. Subjects and methods: Prospective comparative interventional randomized study involving 42 eyes of 42 patients aged more than 6 years with congenital ptosis and good levator action. The exclusion criteria were as follows: bilateral ptosis, history of previous surgery, fair or poor levator action, and associated other ocular diseases. Patients were randomized into group A, in which double-armed 5/0 polyester Ethibond were used, and group B, in which double-armed 5/0 Coated Vicryl® (polyglactin 910) suture material we used. Outcomes including eyelid height and stability of eyelid height over time were compared with follow-up data. The MRD was 4.05 ± 0.36 mm and 3.95 ± 0.34 after 1 week for both groups A and B, respectively. At the end of study follow up period (24 weeks), the MRD was 3.60 ± 0.42 mm in group A, and 2.52 ± 0.85 mm in group B. Conclusion: No difference in eyelid height between two groups in early postoperative period, but the postoperative eyelid height was more stable over time in the 5/0 polyester Ethibond group (group A) than in the 5/0 Coated Vicryl® (polyglactin 910) group (group B).

scholarly journals The translation and transmission of ‘diatribal’ verbs in the textual traditions of the Zlatostruj collection

2021 ◽  
Author(s):  
Simeon Dekker
Keyword(s):  
Middle Ages ◽  
Form Equation ◽  
Verb Forms ◽  
Textual History ◽  
History Of ◽  
Textual Traditions ◽  
The Voice ◽  
Over Time ◽  
The Middle Ages

AbstractThe ‘diatribe’ is a dialogical mode of exposition, originating in Hellenistic Greek, where the author dramatically performs different voices in a polemical-didactic discourse. The voice of a fictitious opponent is often disambiguated by means of parenthetical verba dicendi, especially φησί(ν). Although diatribal texts were widely translated into Slavic in the Middle Ages, the textual history of the Zlatostruj collection of Chrysostomic homilies especially suits an investigation not only of how Greek ‘diatribal’ verbs were translated, but also how the Slavic verbs were transmitted or developed in different textual traditions. Over time, Slavic redactional activity led to a homogenization of verb forms. The initial variety of the original translation was partly eliminated, and the verb forms "Equation missing" and "Equation missing" became more firmly established as prototypical diatribal formulae. Especially the (increased) use of the 2sg form "Equation missing" has theoretical consequences for the text’s dialogical structure. Thus, an important dialogical component of the diatribe was reinforced in the Zlatostruj’s textual history on Slavic soil.

ExpanDrogram: Dynamic Visualization of Big Data Segmentation over Time

2021 ◽  
Vol 13 (2) ◽  
pp. 1-27
Author(s):  
A. Khalemsky ◽  
R. Gelbard
Keyword(s):  
Big Data ◽  
Visual Presentation ◽  
Trend Detection ◽  
Dynamic Visualization ◽  
Segmentation Process ◽  
Key Points ◽  
Wide Range ◽  
History Of ◽  
The Individual ◽  
Over Time

In dynamic and big data environments the visualization of a segmentation process over time often does not enable the user to simultaneously track entire pieces. The key points are sometimes incomparable, and the user is limited to a static visual presentation of a certain point. The proposed visualization concept, called ExpanDrogram, is designed to support dynamic classifiers that run in a big data environment subject to changes in data characteristics. It offers a wide range of features that seek to maximize the customization of a segmentation problem. The main goal of the ExpanDrogram visualization is to improve comprehensiveness by combining both the individual and segment levels, illustrating the dynamics of the segmentation process over time, providing “version control” that enables the user to observe the history of changes, and more. The method is illustrated using different datasets, with which we demonstrate multiple segmentation parameters, as well as multiple display layers, to highlight points such as new trend detection, outlier detection, tracking changes in original segments, and zoom in/out for more/less detail. The datasets vary in size from a small one to one of more than 12 million records.

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