scholarly journals Hydroethanolic stem bark extract of Vernonia amygdalina Del. (Asteraceae) suppresses yeast-induced pyrexia and Plasmodium berghei malaria in murine models

2020 ◽  
Vol 14 (6) ◽  
pp. 258-264
Author(s):  
Kwarley Quartey Anna ◽  
Jibira Yakubu ◽  
Forkuo-Donkor Arnold ◽  
Ayensu Isaac ◽  
Agyakoma Oduro-Kwarteng Adwoa ◽  
...  
Keyword(s):  
Plasmodium Berghei ◽  
Stem Bark ◽  
Bark Extract ◽  
Murine Models ◽  
Vernonia Amygdalina ◽  
Stem Bark Extract

scholarly journals Macaranga barteri stem bark extract exerts anti-inflammatory and anti-hyperalgesia activity in murine models

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Evelyn Asante-Kwatia ◽  
Yakubu Jibira ◽  
Abraham Yeboah Mensah ◽  
Debora Osei-Sarfoh
Keyword(s):  
Stem Bark ◽  
Bark Extract ◽  
Murine Models ◽  
Stem Bark Extract ◽  
Anti Inflammatory

scholarly journals The Ethanolic Stem-Bark Extract of Antrocaryon micraster Inhibits Carrageenan-Induced Pleurisy and Pedal Oedema in Murine Models of Inflammation

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Leslie B. Essel ◽  
David D. Obiri ◽  
Newman Osafo ◽  
Aaron O. Antwi ◽  
Babatunde M. Duduyemi
Keyword(s):  
Acute Toxicity ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Tissue Level ◽  
Bark Extract ◽  
Phytochemical Analysis ◽  
Murine Models ◽  
Paw Oedema ◽  
Stem Bark Extract ◽  
Anti Inflammatory

We investigated the antioxidant and anti-inflammatory effects of a 70% v/v ethanol extract of the stem bark of Antrocaryon micraster on murine models of carrageenan-induced pleurisy and paw oedema. Rat pleural fluid was analysed for volume, protein content, and leucocytes, while lung histology was assessed for damage. Lung tissue homogenates were assayed for glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and myeloperoxidase (MPO). Phytochemical analysis was carried out on the stem bark. Acute toxicity studies were conducted in rats. In the pleurisy model the extract (30–300 mg/kg) significantly reduced the volume and amount of proteins and leucocytes in the exudate and also protected against lung injury. Tissue level of GSH and SOD and CAT expression were increased while MDA level and MPO activity were reduced. The peak and total oedema responses were significantly suppressed when given both preemptively and curatively in the mice paw oedema test. Saponins, alkaloids, triterpenoids, and tannins were present in the stem bark. A. micraster extract exhibited no apparent acute toxicity. We conclude that the ethanolic stem-bark extract of A. micraster has antioxidant action and exhibits significant anti-inflammatory activity through suppression of pleurisy and paw oedema induced with carrageenan.

scholarly journals Antiplasmodial Effect ofAnthocleista vogeliion Albino Mice Experimentally Infected withPlasmodium berghei berghei(NK 65)

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Lebari Barine Gboeloh ◽  
Okpok Eta Okon ◽  
Samuel Effiong Udoh
Keyword(s):  
Body Weight ◽  
Plasmodium Berghei ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract ◽  
Albino Mice ◽  
Dose Levels ◽  
Group D ◽  
Dose Dependent ◽  
Different Doses

The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract ofAnthocleista vogeliiat different doses in albino mice infected withPlasmodium berghei berghei(NK 65). Thirty-six mice were divided into six groups of six mice each. Five groups (B1–B3, D, and G) were infected withPlasmodium berghei bergheiparasitized red blood cells. Groups D, H, and G served as the controls. Six days after infection, mice in groups B1, B2, and B3were treated orally with 100, 200, and 400 mg/kg body weight ofAnthocleista vogelii,respectively, for six executive days. Group D was treated with 5 mg/kg body weight of chloroquine while Group G was given distilled water. Group H was not infected and was not treated. It served as the normal control. The extracts exhibited significant(P<0.05)dose-dependent chemosuppression ofP. berghei. The extract exhibited average chemosuppressive effects of 48.5%, 78.5%, and 86.6% at dose levels of 100, 200, and 400 mg/kg body weight, respectively. Phytochemical screening of the plant extract revealed the presence of saponins, cardiac glycosides, flavonoids, terpenes, alkaloids, and steroid. The acute toxicity (LD50) of the plant was estimated to be 3162 mg/kg body weight. It showed that the stem bark ofA. vogeliipossesses antiplasmodial property.

scholarly journals Antimalaria Effect of the Ethanolic Stem Bark Extracts ofFicus platyphyllaDel

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Isma'il Shittu ◽  
Amlabu Emmanuel ◽  
Andrew Jonathan Nok
Keyword(s):  
Survival Time ◽  
Plasmodium Berghei ◽  
Post Infection ◽  
Stem Bark ◽  
Bark Extract ◽  
Drastic Reduction ◽  
Traditional Use ◽  
Experimental Control ◽  
Mean Survival Time ◽  
Stem Bark Extract

The antimalarial effect of the ethanolic stem bark extract ofFicus platyphyllaDel was evaluated againstPlasmodium bergheiinfection in mice. Nontreated, experimental control mice died of fulminant parasitemia from day 7 to 9 post-infection but mice treated with the extract at 300 mg/kg showed markedly reduced parasitaemia bouts of 43.50% and a mean survival time of 28 days postinfection. The plant extract prevented a drastic reduction in PCV showing its efficacy in ameliorating anaemic conditions inPlasmodium berghei-infected mice. Histological examination of liver tissues of treated and untreated mice further supports the antimalaria potential of this plant. This observation validates the traditional use of this plant for the treatment of malaria.

scholarly journals Evaluation of Antimalarial Activity of the 80% Methanolic Stem Bark Extract of Combretum molle Against Plasmodium berghei in Mice

2019 ◽  
Vol 24 ◽  
pp. 2515690X1989086 ◽  
Author(s):  
Tafere Mulaw ◽  
Muluken Wubetu ◽  
Bekalu Dessie ◽  
Gebreselassie Demeke ◽  
Yalew Molla
Keyword(s):  
Crude Extract ◽  
Plasmodium Berghei ◽  
Antimalarial Activity ◽  
Stem Bark ◽  
Negative Control ◽  
Bark Extract ◽  
Traditional Use ◽  
Combretum Molle ◽  
Group I ◽  
Stem Bark Extract

Background. People are dependent on the traditional use of medicinal plants for the treatment of malaria without scientific validations. Therefore, this study aimed to evaluate the antimalarial activity of methanolic stem bark extract of Combretum molle in mice. Methods. After being infected with Plasmodium berghei, the mice were randomly divided into 5 groups (n = 5). In all cases, group I mice were treated as negative control and received 3% Tween 80; group II mice were treated with 25 mg/kg chloroquine; and groups III, IV, and V mice were treated with 100 mg/kg, 200 mg/kg, and 400 mg/kg of crude extract, respectively. Data were analyzed using one-way analysis of variance followed by Tukey’s post hoc analysis. Results. In the chemosuppressive test, the parasitic suppression effect of the crude extract was found to be significant ( P < 0.05) as compared with the negative control. In the curative experiment, the average parasitic level of those mice treated by the 3 doses of the crude extract was significantly suppressed at days 5, 6, and 7 of treatment ( P < 0.001). Besides, the crude extract had been found to have a chemoprophylactic role as it inhibited the parasite level significantly relative to the negative control ( P < 0.001). Moreover, the crude extract had preventive effects on packed cell volume reduction in the 3 tests ( P < 0.001). Conclusions. The findings of the present study has supported the folklore use of the leaves of Combretum molle in the treatment of malaria. Therefore, further fractionation and characterization of the crude extract is necessary to identify the responsible lead compound(s) responsible for antiplasmodial activity.

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