scholarly journals Protective effects of ginger (Zingiber officinale Roscoe) against cadmium chloride-induced oxidative stress in the blood of rats

2014 ◽  
Vol 8 (39) ◽  
pp. 1164-1172 ◽  
Author(s):  
M. M. Attia Atef, ◽  
A. A. Ibrahim Fatma, ◽  
A. Abd EL-Latif Noha, ◽  
W. Aziz Samir, ◽  
A. Abdelmottaleb Moussa Sherif
Keyword(s):  
Oxidative Stress ◽  
Cadmium Chloride ◽  
Zingiber Officinale ◽  
Protective Effects ◽  
Zingiber Officinale Roscoe

Vasculoprotective effects of ginger (Zingiber officinale Roscoe) and underlying molecular mechanisms

2021 ◽  
Author(s):  
Chao Li ◽  
Jie Li ◽  
Feng Jiang ◽  
Nikolay T. Tzvetkov ◽  
Jaroslaw O. Horbanczuk ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Molecular Mechanisms ◽  
Zingiber Officinale ◽  
Protective Effects ◽  
Bioactive Constituents ◽  
Zingiber Officinale Roscoe

Bioactive constituents of ginger are reviewed. Vascular protective effects of ginger and a variety of mechanisms are presented. Ginger and its components show vasculoprotective effects in clinical trials.

scholarly journals Redox properties of ginger extracts: Perspectives of use of Zingiber officinale Rosc. as antidiabetic agent

2013 ◽  
Vol 6 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Lucia Račková ◽  
Mária Cupáková ◽  
Anton Ťažký ◽  
Júlia Mičová ◽  
Emil Kolek ◽  
...  
Keyword(s):  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Zingiber Officinale ◽  
Protective Effects ◽  
Β Cells ◽  
Cytotoxic Effects ◽  
Stress Markers ◽  
Zingiber Officinale Roscoe ◽  
Low Cytotoxicity ◽  
Free Radical Scavenging Activities

Abstract In traditional medicine, several medicinal plants or their extracts have been used to treat diabetes. Zingiber officinale Roscoe, known commonly as ginger, is consumed worldwide in cookeries as a spice and flavouring agent. It has been used as the spice and medicine for thousands of years. The present study was undertaken to investigate the potential protective effect of Zingiber officinale Rosc. in a model of oxidative damage to pancreatic β cells. The free radical scavenging activities and composition of the isolated n-hexane and ethanolic extracts were confronted with their protective, antioxidant and cytotoxic effects in INS-1E β cells. Unlike the n-hexane extract (exerting, paradoxically, stronger antiradical capacity), both low cytotoxicity and remarkable protective effects on β cell viability, followed by lowering oxidative stress markers were found for the ethanolic extract Zingiber officinale Rosc. The present study is the first pilot study to assess the protective potential of Zingiber officinale Rosc. in a model of cytotoxic conditions imposed by diabetes in β cells.

scholarly journals Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Nur Fatin Nabilah Mohd Sahardi ◽  
Suzana Makpol
Keyword(s):  
Oxidative Stress ◽  
Cell Signalling ◽  
Zingiber Officinale ◽  
Biological Molecules ◽  
Current Evidence ◽  
Degenerative Diseases ◽  
Active Components ◽  
Antioxidant Agents ◽  
Zingiber Officinale Roscoe

Currently, the age of the population is increasing as a result of increased life expectancy. Ageing is defined as the progressive loss of physiological integrity, which can be characterized by functional impairment and high vulnerability to various types of diseases, such as diabetes, hypertension, Alzheimer’s disease (AD), Parkinson’s disease (PD), and atherosclerosis. Numerous studies have reported that the presence of oxidative stress and inflammation contributes to the development of these diseases. In general, oxidative stress could induce proinflammatory cytokines and reduce cellular antioxidant capacity. Increased oxidative stress levels beyond the production of antioxidant agents cause oxidative damage to biological molecules, including DNA, protein, and carbohydrates, which affects normal cell signalling, cell growth, differentiation, and apoptosis and leads to disease pathogenesis. Since oxidative stress and inflammation contribute to these diseases, ginger (Zingiber officinale Roscoe) is one of the potential herbs that can be used to reduce the level of oxidative stress and inflammation. Ginger consists of two major active components, 6-gingerol and 6-shogaol, which are essential for preventing oxidative stress and inflammation. Thus, this paper will review the effects of ginger on ageing and degenerative diseases, including AD, PD, type 2 diabetes mellitus (DM), hypertension, and osteoarthritis.

Chemical Composition and Skin Protective Effects of Essential Oil Obtained from Ginger (Zingiber officinale Roscoe)

2018 ◽  
Vol 21 (6) ◽  
pp. 1542-1549 ◽  
Author(s):  
Jiao Feng ◽  
Zhiyun Du ◽  
Lanyue Zhang ◽  
Wenqian Luo ◽  
Yating Zheng ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Zingiber Officinale ◽  
Protective Effects ◽  
Zingiber Officinale Roscoe

The protective effect of aqueous extract of Typha capensis rhizomes on cadmium-induced infertility in rats

2019 ◽  
Vol 30 (3) ◽  
Author(s):  
Mavuto Masopera Gondwe ◽  
Andile Mpungose ◽  
Davie Rexon Kamadyaapa ◽  
Mathulo Shauli ◽  
Eugene Ndebia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Normal Saline ◽  
Male Fertility ◽  
Cadmium Chloride ◽  
Sperm Count ◽  
Control Group ◽  
Protective Effects ◽  
Histological Assessment ◽  
Group I ◽  
Fertility Problems

Abstract Background Typha capensis is one of the medicinal plants commonly used to manage male fertility problems. The objective of the present study was to assess its fertility-promoting effects in a rat model of cadmium-induced infertility. Methods A total of 30 male Wister rats were randomly divided into five groups of six animals each. Animals of group I, which served as control, were administered with cadmium chloride (CdCl2; 2.5 mg/kg) and normal saline (2 mL/kg). Group II was served with 0.5 mL normal saline only. Animals of groups III–V were treated with CdCl2 (2.5 mg/kg) plus T. capensis extract at doses of 100, 200, and 400 mg/kg, respectively. Animals were sacrificed under sedation. Testes and epididymal weights and sperm count were determined. Histological assessment of the testes was conducted. Results T. capensis at any dose did not improve (p > 0.05) testicular and epididymal weights compared with those of the CdCl2-exposed control group. Histology revealed moderate necrosis in the same group. T. capensis modestly increased the sperm count by 14%, 31%, and 35%, for groups treated with the extract at doses 100, 200, and 400 mg/kg, respectively, when compared with the CdCl2 control group, although the differences were not significant statistically (p > 0.05). Conclusions Results of our study demonstrated that T. capensis can neither offer protective effects against oxidative stress nor promote fertility in an animal model of cadmium-induced infertility.

scholarly journals Antioxidant and Anti-Inflammatory Effects of Zingiber officinale roscoe and Allium subhirsutum: In Silico, Biochemical and Histological Study

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1383
Author(s):  
Nourhene Zammel ◽  
Mohd Saeed ◽  
Nouha Bouali ◽  
Salem Elkahoui ◽  
Jahoor M. Alam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
In Silico ◽  
Histological Study ◽  
Hematological Parameters ◽  
Docking Simulation ◽  
Zingiber Officinale ◽  
Markers Of Inflammation ◽  
Zingiber Officinale Roscoe ◽  
Anti Inflammatory

In this study, the antioxidant and anti-inflammatory effects of Zingiber officinale roscoe and Allium subhirsutum aqueous extracts were examined in a carrageenan-induced acute inflammation model. Some markers of inflammation such as hematological parameters, fibrinogen and C-reactive protein were measured. Variables reflecting oxidative stress included thiobarbituric acid reactive substances (TBARS), advanced oxidation of protein products (AOPP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione were determined in both inflamed foci and erythrocytes. The in silico molecular docking simulation showed that the main components of Zingiber officinale roscoe and Allium subhirsutum bound to toll-like receptor 6 (TLR6) with high affinities. Moreover, histological examinations of paw edema were carried out. Both Zingiber officinale roscoe and Allium subhirsutum ameliorated the induced inflammation and oxidative stress status as outlined by anti-edematous, antioxidant and anti-inflammatory activities. Our investigation lends pharmacological support to the medical uses of these spices in the management of inflammatory disorders and oxidative damage. The results of the in silico assay satisfactory explain the in vivo effects as compared with indomethacin.

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