Vasculoprotective effects of ginger (Zingiber officinale Roscoe) and underlying molecular mechanisms

2021 ◽  
Author(s):  
Chao Li ◽  
Jie Li ◽  
Feng Jiang ◽  
Nikolay T. Tzvetkov ◽  
Jaroslaw O. Horbanczuk ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Molecular Mechanisms ◽  
Zingiber Officinale ◽  
Protective Effects ◽  
Bioactive Constituents ◽  
Zingiber Officinale Roscoe

Bioactive constituents of ginger are reviewed. Vascular protective effects of ginger and a variety of mechanisms are presented. Ginger and its components show vasculoprotective effects in clinical trials.

scholarly journals Redox properties of ginger extracts: Perspectives of use of Zingiber officinale Rosc. as antidiabetic agent

2013 ◽  
Vol 6 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Lucia Račková ◽  
Mária Cupáková ◽  
Anton Ťažký ◽  
Júlia Mičová ◽  
Emil Kolek ◽  
...  
Keyword(s):  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Zingiber Officinale ◽  
Protective Effects ◽  
Β Cells ◽  
Cytotoxic Effects ◽  
Stress Markers ◽  
Zingiber Officinale Roscoe ◽  
Low Cytotoxicity ◽  
Free Radical Scavenging Activities

Abstract In traditional medicine, several medicinal plants or their extracts have been used to treat diabetes. Zingiber officinale Roscoe, known commonly as ginger, is consumed worldwide in cookeries as a spice and flavouring agent. It has been used as the spice and medicine for thousands of years. The present study was undertaken to investigate the potential protective effect of Zingiber officinale Rosc. in a model of oxidative damage to pancreatic β cells. The free radical scavenging activities and composition of the isolated n-hexane and ethanolic extracts were confronted with their protective, antioxidant and cytotoxic effects in INS-1E β cells. Unlike the n-hexane extract (exerting, paradoxically, stronger antiradical capacity), both low cytotoxicity and remarkable protective effects on β cell viability, followed by lowering oxidative stress markers were found for the ethanolic extract Zingiber officinale Rosc. The present study is the first pilot study to assess the protective potential of Zingiber officinale Rosc. in a model of cytotoxic conditions imposed by diabetes in β cells.

scholarly journals Supercritical Fluid Extract of Angelica sinensis and Zingiber officinale Roscoe Ameliorates TNBS-Induced Colitis in Rats

2019 ◽  
Vol 20 (15) ◽  
pp. 3816
Author(s):  
Jia Liu ◽  
Ling Yu ◽  
Nuolan Mo ◽  
Hai Lan ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Supercritical Fluid ◽  
Cell Model ◽  
Zingiber Officinale ◽  
Underlying Mechanism ◽  
Chinese Herbs ◽  
Angelica Sinensis ◽  
Bioactive Constituents ◽  
Trinitrobenzenesulfonic Acid ◽  
Zingiber Officinale Roscoe

Inflammatory bowel disease (IBD) is a worldwide healthcare problem calling for the development of new therapeutic drugs. Angelica sinensis and Zingiber officinale Roscoe are two common dietetic Chinese herbs, which are traditionally used for complementary treatment of gastrointestinal disorders. As bioactive constituents, volatile and pungent substances of these two herbs could be effectively extracted together by supercritical fluid extraction. In this study, the supercritical fluid extract of Angelica sinensis and Zingiber officinale Roscoe (AZ-SFE) was obtained by an optimized extraction process and it was chemically characterized. The anti-inflammatory effect and underlying mechanism of AZ-SFE were evaluated in a lipopolysaccharide (LPS)-induced RAW264.7 cell model and a 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rat model. AZ-SFE notably inhibited the production of NO in LPS-stimulated macrophages, and it inhibited the proliferation of Concanavalin A (Con A)-induced splenocytes with suppression of the Th1 immune response. In vivo, the study demonstrated that AZ-SFE significantly alleviated disease activity, colonic shortening, macroscopic damage and histological injury of TNBS-treated rats with reduction of oxidative stress, suppression of inflammatory cytokines, and modulation of hepcidin and serum iron. These findings suggested that AZ-SFE may be a promising supplement for current IBD therapy.

The Effect of Drying Methods on Physicochemical Properties of Nanostructured Zingiber officinale Rosc. (Ginger) Rhizome

2013 ◽  
Vol 667 ◽  
pp. 458-463 ◽  
Author(s):  
A. Norhidayah ◽  
A. Noriham ◽  
Mohamad Rusop
Keyword(s):  
Zingiber Officinale ◽  
Spherical Particles ◽  
Total Phenolic ◽  
Drying Methods ◽  
Particle Sizes ◽  
Drying Process ◽  
Bioactive Constituents ◽  
Freeze Dried ◽  
Zingiber Officinale Roscoe ◽  
Surface Morphologies

Zingiber officinale Roscoe, family of Zingiberaceae is classified as traditional medicinal that globally consumed as spices, food flavouring as well as remedies to treat women during confinement, to treat stomach upset and diarrhoea.The rhizome has been reported to contain abundant bioactive constituents which are mainly polyphenol and flavonoid. Therefore in this research the effect of cabinet drying (60°C) and freeze drying (-40°C) process during preparation of nanostructure Zingiber officinale Roscoe rhizome on particle sizes, surface morphology, FTIR, as well as Total Phenolic Content (TPC) and Total Flavonoid Content(TFC) were compared. Both drying process affect the particle sizes as well as TPC and TFC value. Finer particle size (254.3+ 9.33) and higher TPC (152.54 mg GAE/ g) and TFC (1.42 mgQE/g) were reported for cabinet dried nanostructure Zingiber officinale Rosc. rhizome as compared to freeze dried. The FESEM Photographs revealed that drying processes did affect the surface morphologies of nanostructure Zingiber officinale Rosc rhizome where cabinet dried produced solid spherical particles with a diameter around 100 – 200 nm and some smaller than100nm. Freeze dried consist of many nanoparticles having rod like structure. Both drying process did not significantly affect the presence of active compounds based on FTIR analysis.

scholarly journals Protective effects of ginger (Zingiber officinale Roscoe) against cadmium chloride-induced oxidative stress in the blood of rats

2014 ◽  
Vol 8 (39) ◽  
pp. 1164-1172 ◽  
Author(s):  
M. M. Attia Atef, ◽  
A. A. Ibrahim Fatma, ◽  
A. Abd EL-Latif Noha, ◽  
W. Aziz Samir, ◽  
A. Abdelmottaleb Moussa Sherif
Keyword(s):  
Oxidative Stress ◽  
Cadmium Chloride ◽  
Zingiber Officinale ◽  
Protective Effects ◽  
Zingiber Officinale Roscoe

scholarly journals Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

Foods ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 340 ◽  
Author(s):  
Xiao Meng ◽  
Jing Zhou ◽  
Cai-Ning Zhao ◽  
Ren-You Gan ◽  
Hua-Bin Li
Keyword(s):  
Clinical Trials ◽  
Cardiovascular Diseases ◽  
Chronic Diseases ◽  
Liver Diseases ◽  
Molecular Mechanisms ◽  
Health Benefits ◽  
Experimental Studies ◽  
Bioactive Compound ◽  
Protective Effects ◽  
Epidemiological Surveys

Resveratrol is a bioactive compound in many foods. Since its anticancer activity was reported in 1997, its health benefits have been intensively investigated. Resveratrol has antioxidant, anti-inflammatory, immunomodulatory, glucose and lipid regulatory, neuroprotective, and cardiovascular protective effects, therefore, can protect against diverse chronic diseases, such as cardiovascular diseases (CVDs), cancer, liver diseases, obesity, diabetes, Alzheimer’s disease, and Parkinson’s disease. This review summarizes the main findings of resveratrol-related health benefits in recent epidemiological surveys, experimental studies, and clinical trials, highlighting its related molecular mechanisms. Resveratrol, therefore, has been regarded as a potent candidate for the development of nutraceuticals and pharmaceuticals to prevent and treat certain chronic diseases.

Chemical Composition and Skin Protective Effects of Essential Oil Obtained from Ginger (Zingiber officinale Roscoe)

2018 ◽  
Vol 21 (6) ◽  
pp. 1542-1549 ◽  
Author(s):  
Jiao Feng ◽  
Zhiyun Du ◽  
Lanyue Zhang ◽  
Wenqian Luo ◽  
Yating Zheng ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Zingiber Officinale ◽  
Protective Effects ◽  
Zingiber Officinale Roscoe

scholarly journals Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

2021 ◽  
Vol 12 ◽  
Author(s):  
Jeremiah Oshiomame Unuofin ◽  
Nelisiwe Prenate Masuku ◽  
Oluwatomiwa Kehinde Paimo ◽  
Sogolo Lucky Lebelo
Keyword(s):  
Clinical Trials ◽  
Male Infertility ◽  
Biological Activities ◽  
Scientific Evidence ◽  
Zingiber Officinale ◽  
Docking Studies ◽  
Nausea And Vomiting ◽  
Receptor Protein ◽  
Protective Effects ◽  
Tract Infections

Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.

Protective effects of soy-isoflavones in cardiovascular disease

2008 ◽  
Vol 28 (01/02) ◽  
pp. 85-88 ◽  
Author(s):  
D. Fuchs ◽  
H. Daniel ◽  
U. Wenzel
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Molecular Mechanisms ◽  
Dietary Intervention ◽  
Mononuclear Cells ◽  
Oxidized Ldl ◽  
Proteome Analysis ◽  
Soy Isoflavones ◽  
Protective Effects ◽  
Estrogen Production

SummaryEpidemiological studies indicate that the consumption of soy-containing food may prevent or slow-down the development of cardiovascular disease. In endothelial cells application of a soy extract or a combination of the most abundant soy isoflavones genistein and daidzein both inhibited apoptosis, a driving force in atherosclerosis development, when applied in combination with oxidized LDL or homocysteine. Proteome analysis revealed that the stressorinduced alteration of protein expression profile was reversed by the soy extract or the genistein/daidzein mixture. Only few protein entities that could be functionally linked to mitochondrial dysfunction were regulated in common by both application forms of isoflavones. A dietary intervention with isoflavone-enriched soy extract in postmenopausal women, who generally show strongly increased cardiovascular risk due to diminished estrogen production, led to significant alterations in the steady state levels of proteins from mononuclear blood cells. The proteins identified by proteome analysis revealed that soy isoflavones may increase the anti-inflammatory response in blood mononuclear cells thereby contributing to the atherosclerosispreventive activities of a soy-rich diet. Conclusion: By proteome analysis protein targets were identified in vitro in endothelial cells that respond to soy isoflavones and that may decipher molecular mechanisms through which soy products exert their protective effects in the vasculature.

Молекулярно-клеточные механизмы стресс-протективной активности растительного адаптогенного средства «Кардекаим» на фоне острого эмоционального стресса

2018 ◽  
Vol 81 (2) ◽  
pp. 17-20
Author(s):  
Эльвира Алексеевна Алексеева ◽  
О. Г. Димитров ◽  
Л. Н. Шантанова ◽  
С. М. Николаев ◽  
Е. Н. Карева ◽  
...  
Keyword(s):  
Zingiber Officinale ◽  
Hsp 70 ◽  
Zingiber Officinale Roscoe ◽  
Inula Helenium

Изучены адаптогенные свойства растительного средства «Кардекаим», представляющего собой сухой экстракт из сырья Inula helenium L., Zingiber officinale Roscoe, Elletaria cardamomum (L.) Maton., Caragana spinosa (L.) Wall. ex Hornem. и содержащего в качестве действующих веществ фенольные соединения и терпеноиды. Курсовое превентивное введение кардекаима в дозе 100 мг/кг в течение 7 дней перед острым эмоциональным стрессом оказывает выраженное стресс-протективное действие, препятствуя развитию признаков «триады Селье»: инволюции вилочковой железы (40 %), язвенным повреждениям слизистой оболочки желудка (в 5 раз) и в меньшей степени — гипертрофии надпочечников (p ≤ 0,05), полученный эффект не уступает препарату сравнения — экстракту элеутерококка. Показано, что повышение резистентности к стрессу под влиянием кардекаима сопровождается активацией синтеза белков теплового шока (Hsp-70), не связанной со стресс-индуцированной генерацией NO.

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