scholarly journals Bactericidal activities of the leaf extract of Spondias mombin L. plant used for culinary and therapeutically purposes in Ivory Coast

2020 ◽  
Vol 12 (1) ◽  
pp. 1-16
Author(s):  
Ahou Kouadio Irène ◽  
Amin Yapi Paulin ◽  
Sanogo Moussa
Keyword(s):  
Ivory Coast ◽  
Leaf Extract ◽  
Spondias Mombin ◽  
Bactericidal Activities

scholarly journals Toxicological evaluation of aqueous leaf extract of Spondias mombin using albino rat

2018 ◽  
pp. 23-30
Author(s):  
NWAOGWUGWU JOEL, FRIDAY UHEGBU ◽  
OKEREKE STANLEY, EGEGE AMAKA, ATASI OKECHUKWU
Keyword(s):  
Leaf Extract ◽  
Lethal Dose ◽  
Albino Rats ◽  
Albino Rat ◽  
Toxicological Evaluation ◽  
Spondias Mombin ◽  
Reduced Body ◽  
Aqueous Leaf Extract ◽  
Dose Dependent ◽  
Different Doses

Toxicological evaluation of aqueous leaf extract of Spondias mombin using albino rat was carried out. Twenty-five albino rats were grouped into five groups of five rats each. Group 1 served as the control, while groups 2-5 served as the test groups. The test groups were placed on different doses of the studied leaf extract after the lethal dose was determined. The studied extractconsists mainly of flavonoids, saponins, alkaloid, tannins and cyanogenic glycosides, which have considerable therapeutic values, and reduced body weight considerably in test rats against the control. Levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)in test rats reduced significantly (p<0.05) when compared to the control. However, the observed histopathological changes associated with the kidney and liver of test rats against those of the control may suggest that the toxicity of the extract could be dose dependent. This study has shown the toxicological evaluation of aqueous leaf extract of S. mombin using albino rat.

scholarly journals Garcinia Mangostana Leaf Extracts from Ivory Coast Possess Remarkable Antioxidant, Anti-Inflammatory, and Cytotoxicological Properties

2019 ◽  
Vol 12 (2) ◽  
pp. 571-578
Author(s):  
Inès Christelle Chadon Alphonsine Assemian ◽  
Abdelhakim Bouyahya ◽  
Nadia Dakka ◽  
Youssef Bakri
Keyword(s):  
Ivory Coast ◽  
Leaf Extract ◽  
Diclofenac Sodium ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Garcinia Mangostana ◽  
Leaf Extracts ◽  
Standard Drug ◽  
Anti Inflammatory

Garcinia mangostana L. is medicinal plant. Its fruit, the mangosteen contains many bioactive xanthones. This study investigates the potential of organic leaf extracts of G. mangostana grown in Ivory Coast. We tested two organic leaf extracts: G. mangostana aqueous ethanolic leaf extract (ethanol: water, 80:20 v/v) (GMLE) and dichloromethane leaf extract (GMLD). We measured total phenolic and total Flavonoids. We analysed the in vitro anti-inflammatory, anti-radical and anti-proliferative activities of leaf extracts. Ethanol leaf extract showed a considerable amount of phenolic content (328.78±34.32 mg GAE/g) and moderate flavonoids content (43.60±1.48 mg QE/g), Dichloromethane extract had low values of phenolic (70.31±4.55 mg GAE/g) and flavonoids (8.49±0.69 mg QE/g). However, GMLD extract gave a significant anti-inflammatory activity (IC50=152.79±3.34 µg/mL), comparable to the standard drug diclofenac sodium (IC50=142.30±1.22 µg/mL), contrary to GMLE extract (IC50=652.33±12.23 µg/mL). The radical scavenging assay showed a very significant ability of ethanol leaf extract to reduce the DPPH radical (IC50=33.40±0.67 µg/mL) compared to references molecules such as Trolox (IC50=43.72±0.31 µg/mL) and acid ascorbic (IC50=27.20±0.17 µg/mL), dichloromethane extract results showed lowest activity (IC50 = 580.00±23.03 µg/mL). All the organic leaf extracts of G. mangostana had moderate anti-proliferative activity on L20B, RD and VS cell lines studied with IC50 values ranging from 110.89 ±4.82 µg/mL to 860.60±25.78 µg/mL). Our results prove the high potential of the G. mangostana leave extracts as anti-inflammatory and anti-oxidative stress drugs. However, further studies are to determine and validate all the medicinal properties of G. mangostana leaves extracts.

EFFECT OF PRE-COPULATORY TREATMENT WITH AQUEOUS LEAF EXTRACT OF Spondias mombin ON GESTATIONAL CHARACSTERISTICS OF RABBITS

2019 ◽  
Vol 16 (2) ◽  
pp. 83-87
Author(s):  
A. A. OLOYE ◽  
N. OBI
Keyword(s):  
Birth Weight ◽  
Litter Size ◽  
Leaf Extract ◽  
Control Group ◽  
Gestation Length ◽  
Spondias Mombin ◽  
Average Litter Size ◽  
Aqueous Leaf Extract ◽  
And Control

Fifteen plurigravida rabbits weighing between 2.0 and 2.6 kg were used for the study of gestational characteristics after pre-copulatory oral administration of aqueous leaf extract of Spondias mombin. The fifteen does were divided into three groups of five does per group. Four untreated reproductively proven bucks kept separately in different cages were used for copulation. Dosages administered were 400mg/kg and 800mg/kg for groups A and B respectively while distilled water was served to control group C. Mating, pregnancy diagnosis using ultrasound and determination of birth parameters were conducted subsequently at the end of extract treatment. Average litter size,birth weight and gestation length observed in all dosage groups had statistically similar values (p≥0.05).However, it is worth noting the relatively higher values of average litter size in 800mg/kg dosage group and control (5.60±0.40) compared to 400mg/kg group (5.40±0.75) and the highest birth weight value recorded for 800mg/kg (46.63±3.55) compared to 400mg\kg group (45.30±3.22) and control (42.38±3.74). It was concluded that pre-copulatory administration of aqueous leaf extract of Spondias mombin at dosages as high as 800mg/kg to rabbit does not have deleterious effect on its prolificacy and does have pro-fertility tendencies.        

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