scholarly journals Is moist exposed burn ointment effective for diabetic foot ulcers? A meta-analysis of randomized controlled trials

2017 ◽  
Vol 9 (12) ◽  
pp. 174-194
Author(s):  
Liu Lian ◽  
Wei Su Song ◽  
Zhou Ping ◽  
Song Ru ◽  
Yan Sun Hong
Keyword(s):  
Randomized Controlled Trials ◽  
Diabetic Foot ◽  
Meta Analysis ◽  
Foot Ulcers ◽  
Controlled Trials ◽  
Diabetic Foot Ulcers ◽  
Randomized Controlled

scholarly journals Nutritional Supplementation for Diabetic Foot Ulcers: The Big Challenge

2017 ◽  
Vol 16 (4) ◽  
pp. 226-229 ◽  
Author(s):  
Prashant R. J. Vas ◽  
Michael E. Edmonds ◽  
Nikolaos Papanas
Keyword(s):  
Randomized Controlled Trials ◽  
Diabetic Foot ◽  
Patient Adherence ◽  
Nutritional Supplementation ◽  
Foot Ulcers ◽  
Controlled Trials ◽  
Diabetic Foot Ulcers ◽  
Therapeutic Measure ◽  
Randomized Controlled ◽  
Optimal Duration

Diabetic foot ulcers remain difficult to heal and nutritional supplementation may be an important complementary therapeutic measure. However, we need to clarify many issues before such supplementation is more widely used. Indeed, improvements are needed in the following areas: evaluation of nutritional inadequacy, completion of randomized controlled trials, understanding of patient and ulcer characteristics that favor response to nutritional supplementation, optimal duration of supplementation therapy, and evaluation of patient adherence. The challenge is now to acquire more knowledge in the aforementioned areas.

scholarly journals The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-18 ◽  
Author(s):  
Elahe Mahdipour ◽  
Amirhossein Sahebkar
Keyword(s):  
Systematic Review ◽  
Growth Factors ◽  
Growth Factor ◽  
Recombinant Proteins ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Controlled Trials ◽  
Diabetic Foot Ulcers ◽  
Randomized Controlled

Background. Recombinant proteins and growth factors are emerging therapies for diabetic foot ulcers. Despite several clinical reports, there has been no comprehensive and systematic assessment of the totality of clinical evidence on the efficacy and safety of recombinant proteins and growth factors in diabetic foot ulcers. We tried to address this gap through an updated systematic review of randomized controlled trials (RCTs). Methods. PubMed, the Cochrane Library, Scopus, Embase, and Google Scholar databases were searched, and RCTs on the efficacy of recombinant proteins and growth factors in the treatment of cutaneous wounds in diabetic patients were selected. The literature search and assessment were performed by two independent reviewers. Methodological quality of studies was appraised using the Jadad scale. Results. We identified 26 RCTs involving diabetic patients with ulcer that evaluated the effectiveness of platelet-derived growth factor, epidermal growth factor, fibroblast growth factor, granulocyte colony-stimulating factor, vascular endothelial growth factor, erythropoietin, transforming growth factor, talactoferrin, and rusalatide acetate. The main primary outcome was complete healing though different indices were employed to define this such as wound closure, granulation tissue formation, or complete reepithelialization. Few studies had a follow-up period to report any recurrence and amputation rate. No adverse effect was reported due to the intervention. Conclusion. Overall, there is a greater agreement on the effectiveness of EGF to enhance the healing of diabetic ulcers. Nevertheless, extant evidence is lacking for other agents since few trials have been conducted for most of the growth factors and available studies are heterogeneous in their methodologies.

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