scholarly journals The effect of low‐level laser therapy on diabetic foot ulcers: A meta‐analysis of randomised controlled trials

2021 ◽  
Author(s):  
Jing Huang ◽  
Jiangqiong Chen ◽  
Shuyuan Xiong ◽  
Jingui Huang ◽  
Zhiping Liu
Keyword(s):  
Laser Therapy ◽  
Diabetic Foot ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Low Level Laser Therapy ◽  
Foot Ulcers ◽  
Controlled Trials ◽  
Diabetic Foot Ulcers ◽  
Level Laser ◽  
Randomised Controlled

A Systematic Review and Meta-Analysis of the Effects of Low-Level Laser Therapy in the Treatment of Diabetic Foot Ulcers

2020 ◽  
pp. 153473462091443
Author(s):  
Cristiana Maria dos Santos ◽  
Rebeca Barbosa da Rocha ◽  
Fuad Ahmad Hazime ◽  
Vinicius Saura Cardoso
Keyword(s):  
Systematic Review ◽  
Laser Therapy ◽  
Diabetic Foot ◽  
Meta Analysis ◽  
Low Level Laser Therapy ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser

Diabetic foot ulcers (DFUs) are considered one of the most aggressive and expensive complications of diabetes. Low-level laser therapy (LLLT) has been highlighted as a potential modality of treatment to accelerate the healing of ulcers. This systematic review and meta-analysis aimed to investigate the efficacy of LLLT in the treatment of DFU and identify the LLLT application parameters recommended for the treatment of DFU over the past 10 years. A systematic search was conducted in PubMed, BVS, PEDro, Scopus, Web of Science, and CINAHL up to March 31, 2019. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, randomized controlled trials (RCTs) that assessed the effect of LLLT on the treatment of DFU were included. Thirteen RCTs with a total of 361 participants were included in this review. Three RCTs reported a reduction in the percentage size of the ulcers and were included in the meta-analysis. The meta-analysis of the percentage size difference demonstrated a significant reduction in ulcer size in the LLLT group compared with controls (22.96 [95% confidence interval = 18.22-27.69; z = 9.51, P < .0001]). Treatment with 632.8 to 685 nm, 50 mW/cm2, 3 to 6 J/cm2, and irradiation for 30 to 80 seconds, 3 times weekly for a month is of benefit to patients with DFU. LLLT is effective and safe for the treatment of DFU. Additionally, well-designed, high-quality studies are needed to allow its ideal parameterization for clinical practice.

scholarly journals Low Level Laser Therapy for the Treatment of Diabetic Foot Ulcers: A Critical Survey

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Kathrin H. Beckmann ◽  
Gesa Meyer-Hamme ◽  
Sven Schröder
Keyword(s):  
Clinical Trials ◽  
Laser Therapy ◽  
Diabetic Foot ◽  
Animal Studies ◽  
Wound Care ◽  
Low Level Laser Therapy ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Low Level Laser ◽  
Level Laser

Diabetic foot ulcers as one of the most common complications of diabetes mellitus are defined as nonhealing or long-lasting chronic skin ulcers in diabetic patients. Multidisciplinary care for the diabetic foot is common, but treatment results are often unsatisfactory. Low level laser therapy (LLLT) on wound areas as well as on acupuncture points, as a noninvasive, pain-free method with minor side effects, has been considered as a possible treatment option for the diabetic foot syndrome. A systematic literature review identified 1764 articles on this topic. Finally, we adopted 22 eligible references; 8 of them were cell studies, 6 were animal studies, and 8 were clinical trials. Cell studies and animal studies gave evidence of cellular migration, viability, and proliferation of fibroblast cells, quicker reepithelization and reformed connective tissue, enhancement of microcirculation, and anti-inflammatory effects by inhibition of prostaglandine, interleukin, and cytokine as well as direct antibacterial effects by induction of reactive oxygen species (ROS). The transferral of these data into clinical medicine is under debate. The majority of clinical studies show a potential benefit of LLLT in wound healing of diabetic ulcers. But there are a lot of aspects in these studies limiting final evidence about the actual output of this kind of treatment method. In summary, all studies give enough evidence to continue research on laser therapy for diabetic ulcers, but clinical trials using human models do not provide sufficient evidence to establish the usefulness of LLLT as an effective tool in wound care regimes at present. Further well designed research trials are required to determine the true value of LLLT in routine wound care.

scholarly journals Effects of the Low-Level Laser Therapy (LLLT) in the process of healing diabetic foot ulcers

2015 ◽  
Vol 30 (12) ◽  
pp. 852-857 ◽  
Author(s):  
Maura Cristina Porto Feitosa ◽  
Ana Flávia Machado de Carvalho ◽  
Valrian Campos Feitosa ◽  
Isabely Madalena Coelho ◽  
Rauirys Alencar de Oliveira ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Diabetic Foot ◽  
Low Level Laser Therapy ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser
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