Efficacy of low‐level light therapy for improving healing of diabetic foot ulcers: A systematic review and meta‐analysis of randomized controlled trials

2020 ◽  
Author(s):  
Yuanpei Zhou ◽  
Hoon Woon Audrey Chia ◽  
Huey Weng Krystle Tang ◽  
Su Ying Jasmine Lim ◽  
Wen Ya Toh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Diabetic Foot ◽  
Meta Analysis ◽  
Light Therapy ◽  
Foot Ulcers ◽  
Controlled Trials ◽  
Diabetic Foot Ulcers ◽  
Low Level Light Therapy ◽  
Randomized Controlled

scholarly journals The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-18 ◽  
Author(s):  
Elahe Mahdipour ◽  
Amirhossein Sahebkar
Keyword(s):  
Systematic Review ◽  
Growth Factors ◽  
Growth Factor ◽  
Recombinant Proteins ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Controlled Trials ◽  
Diabetic Foot Ulcers ◽  
Randomized Controlled

Background. Recombinant proteins and growth factors are emerging therapies for diabetic foot ulcers. Despite several clinical reports, there has been no comprehensive and systematic assessment of the totality of clinical evidence on the efficacy and safety of recombinant proteins and growth factors in diabetic foot ulcers. We tried to address this gap through an updated systematic review of randomized controlled trials (RCTs). Methods. PubMed, the Cochrane Library, Scopus, Embase, and Google Scholar databases were searched, and RCTs on the efficacy of recombinant proteins and growth factors in the treatment of cutaneous wounds in diabetic patients were selected. The literature search and assessment were performed by two independent reviewers. Methodological quality of studies was appraised using the Jadad scale. Results. We identified 26 RCTs involving diabetic patients with ulcer that evaluated the effectiveness of platelet-derived growth factor, epidermal growth factor, fibroblast growth factor, granulocyte colony-stimulating factor, vascular endothelial growth factor, erythropoietin, transforming growth factor, talactoferrin, and rusalatide acetate. The main primary outcome was complete healing though different indices were employed to define this such as wound closure, granulation tissue formation, or complete reepithelialization. Few studies had a follow-up period to report any recurrence and amputation rate. No adverse effect was reported due to the intervention. Conclusion. Overall, there is a greater agreement on the effectiveness of EGF to enhance the healing of diabetic ulcers. Nevertheless, extant evidence is lacking for other agents since few trials have been conducted for most of the growth factors and available studies are heterogeneous in their methodologies.

scholarly journals Nutritional Supplementation for Diabetic Foot Ulcers: The Big Challenge

2017 ◽  
Vol 16 (4) ◽  
pp. 226-229 ◽  
Author(s):  
Prashant R. J. Vas ◽  
Michael E. Edmonds ◽  
Nikolaos Papanas
Keyword(s):  
Randomized Controlled Trials ◽  
Diabetic Foot ◽  
Patient Adherence ◽  
Nutritional Supplementation ◽  
Foot Ulcers ◽  
Controlled Trials ◽  
Diabetic Foot Ulcers ◽  
Therapeutic Measure ◽  
Randomized Controlled ◽  
Optimal Duration

Diabetic foot ulcers remain difficult to heal and nutritional supplementation may be an important complementary therapeutic measure. However, we need to clarify many issues before such supplementation is more widely used. Indeed, improvements are needed in the following areas: evaluation of nutritional inadequacy, completion of randomized controlled trials, understanding of patient and ulcer characteristics that favor response to nutritional supplementation, optimal duration of supplementation therapy, and evaluation of patient adherence. The challenge is now to acquire more knowledge in the aforementioned areas.

scholarly journals Light Therapy Reduces Fatigue in Patients With Cancer: Protocol for a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Panpan Xiao ◽  
Siqing Ding ◽  
Yinglong Duan ◽  
Lijun Li ◽  
Yi Zhou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Light Therapy ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Randomized Controlled ◽  
Review Team

Abstract BackgroundFatigue is a common symptom in cancer patients that can occur throughout the course of cancer, with a prevalence ranging from 75% to 100%. Nonpharmacological intervention is currently mainly used to address cancer-related fatigue (CRF). Light therapy has been gradually used to treat CRF and has been found to be effective. However, to date, there is no systematic review on light therapies for reducing CRF to verify its effectiveness. This is a protocol for a systematic review that aims to evaluate the effectiveness of light therapies for treating fatigue in cancer survivors. This systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) database.MethodsThis protocol was designed in accordance with the PRISMA-P guidelines. We will search the PubMed, Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library), Embase (OVID), and CINAHL databases as well as relevant sources of gray literature. Randomized controlled trials (RCTs) and quasi-experimental trials that have evaluated the use of light therapy among cancer patients at any survival phase, with fatigue as an outcome measure, will be included. Two members of the review team will independently extract data from the selected studies and assess their methodological quality using the Cochrane Collaboration Risk of Bias Tool.DiscussionThis systematic review and meta-analysis will build upon previous evaluations of light therapies in patients during and after cancer treatment. Due to the multifactorial nature of CRF and the growing demand for etiological-based intervention research, this review seeks to highlight a gap in current practice and to strengthen the evidence base of randomized controlled trials in the area.Systematic review registrationCRD42020215446

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