The hepato-rejuvinative and hepato-toxic capabilities of Citrus paradisi Macfad fruit juice in Rattus Norvegicus

Author(s):  
Saalu, L. C.
2019 ◽  
Vol 6 (2) ◽  
pp. 88-92
Author(s):  
FIFI ALVIANA

Salak (Salacca edulis) is one traditional medicine to treat diarrhea. The content of fruits in the form of tannins and flavonoids that may play a role in overcoming diarrhea.  This study aims to determine the effect of salak fruit juice (Salacca edulis) on defecation frequency and duration of diarrhea in rats (Rattus norvegicus strain (Wistar)).        This study used a sample of white rats wistar strain as much as 30 individuals. The frequency was measured from 1 hour of oleum ricini. Results of measurements performed data analysis using Kruscal-Wallis test and Mann-Witney.        The results of this study showed fruit juice salak (Salacca edulis) showed the first frequency decline in at 7 times / hours becomes 1 times/ hours (p = 0.001) and duration of diarrhea first occurs in 1 hour is 1.25 ± 0.462 hours (p = 0.001). It can be concluded that there are significant salak fruit juice (Salacca edulis) on defecation frequency and duration of diarrhea in rats (Rattus norvegicus strain (wistar)).


2016 ◽  
Vol 07 (10) ◽  
pp. 397-406
Author(s):  
Neelam Mallick ◽  
Rafeeq Alam Khan ◽  
Azra Riaz ◽  
Syeda Afroz

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Bara Pawana Satya Nagara

ABSTRAK Latar Belakang: Kebiasaan masyarakat Indonesia menggunakan obat-obatan yang mudah didapat seperti parasetamol, dimana parasetamol dijual secara bebas akan menyebabkan penyalahgunaannya menjadi lebih besar.Penyalahgunaan ini berakibat timbulnya efek samping  seperti efek hepatotoksik yang menimbulkan kerusakan pada sel-sel hati. Pengendalian efek hepatotoksi didalam tubuh dapat dibantu dengan mengkonsumsi makanan yang mengandung antioksidan. .Ekstrak daun kluwih (Artocarpus camansi) memiliki kandungan antioksidan seperti flavanoid yang diyakini dapat menurunkan aktivitas SGPT dan mengurangi efek toksisitas hepar oleh parasetmol. Tujuan: Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak daun kluwih (Artocarpus camansi) terhadap penurunan aktivitas SGPT  tikus putih (Rattus norvegicus) jantan galur Wistar yang diinduksi parasetamol. Metode: Merupakan post-test only control group mengunakan hewan coba tikus putih jantan galur Wistar yang dikelompokkan menjadi 3 kelompok yaitu kelompok kontrol (-), kelompok kontrol (+), kelompok perlakuan yang mendapat terapi ekstrak daun kluwih (Artocarpus camansi) 500 mg/Kg BB Hasil: Hasil penelitian menunjukkan pemberian ekstrak daun kluwih (Artocarpus camansi) dosis 500 mg/kg/BB/hari pada tikus tidak menurunkan secara bermakna aktivitas SGPT pada kelompok tikus yang diberi parasetamol dosis tinggi ( p=0,401 α=0,05) Kesimpulan: Parasetamol dosis tinggi meningkatkan secara bermakna aktivitas SGPT tikus putih (Rattus norveicus) galur Wistar. Pemberian ekstrak daun kluwih (Artocarpus camansi) pada aktivitas SGPT tikus putih (Rattus norveicus) galur Wistar menurunkan  secara tidak bermakna. Kata kunci : Artocarpus camansi, Parasetamol, SGPT


Author(s):  
Ni Made Ridla Parwata

Overtraining syndrome is a decrease in physical capacity, emotions and immunity due to training that is too often without adequate periods of rest. Overtraining is often experienced by athletes who daily undergo heavy training with short break periods. This research aims to look at the effect of overtraining aerobic physical exercise on memory in mice. The research method was experimental in vivo with the subject of adult male rat (Rattus Norvegicus) Winstar strain aged 8-10 weeks, body weight 200-250 gr. Divided into three groups, namely the control group, aerobic group and overtraining group. The results of memory tests with water E Maze showed an increase in the duration of travel time and the number of animal errors made by the overtraining group (p = 0.003). This study concludes that overtraining aerobic physical exercise can reduce memory in rat hippocampus.


Sign in / Sign up

Export Citation Format

Share Document