scholarly journals Salivary IgA antibody to Bacteroides gingivalis and Actinobacillus actinomycetemcomitans in patients with adult marginal periodontitis.

1987 ◽  
Vol 37 (3) ◽  
pp. 244-249 ◽  
Author(s):  
Makoto SATO ◽  
Atsushi NAGATA ◽  
Reiko MAEHARA ◽  
Junko ENDO ◽  
Daisuke HINODE ◽  
...  
Keyword(s):  
Actinobacillus Actinomycetemcomitans ◽  
Salivary Iga ◽  
Iga Antibody ◽  
Bacteroides Gingivalis ◽  
Marginal Periodontitis

scholarly journals Effects of Euglena gracilis EOD-1 Ingestion on Salivary IgA Reactivity and Health-Related Quality of Life in Humans

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1144 ◽  
Author(s):  
Ken-ichi Ishibashi ◽  
Machiko Nishioka ◽  
Nobuteru Onaka ◽  
Madoka Takahashi ◽  
Daisuke Yamanaka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Euglena Gracilis ◽  
Health Related Quality ◽  
Salivary Iga ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related ◽  
Antibody Titers ◽  
Iga Antibody

Euglena gracilis EOD-1, a microalgal strain known for high yields of the β-1, 3-glucan paramylon, is suggested to function as a dietary fiber and enhance immunity. Here, we aimed to investigate the effects of E. gracilis EOD-1 biomass (EOD1BM) ingestion on immunoglobulin A (IgA) antibody titers in saliva, its reactivity, and the health-related quality of life (QOL) in humans. Reacting human immunoglobulin preparations and saliva with paramylon granules revealed the presence of anti-paramylon antibodies in the blood and saliva. We conducted a placebo-controlled, double-blind, crossover study involving 13 healthy subjects who ingested the placebo or EOD1BM for 4 weeks. Saliva was collected from each subject before and after ingestion, and IgA titers and E. gracilis EOD-1 paramylon (EOD1PM) reactivity were compared. In the EOD1BM Ingestion group, the anti-EOD1PM IgA content and titer increased after EOD1BM ingestion. No such change was observed in the Placebo group. Furthermore, the health-related QOL, especially mental health, increased in the EOD1BM Ingestion group. Thus, EOD1BM ingestion led to the production of paramylon (PM)-specific IgA antibody and increased salivary IgA antibody titers. We demonstrate that EOD1BM ingestion enhanced the immunity in the mucosal surface, evoked an antigen-specific response, and increased the health-related QOL, thereby contributing to health improvement.

scholarly journals Salivary IgA to MAA-LDL and Oral Pathogens Are Linked to Coronary Disease

2019 ◽  
Vol 98 (3) ◽  
pp. 296-303 ◽  
Author(s):  
R. Akhi ◽  
C. Wang ◽  
A.E. Nissinen ◽  
J. Kankaanpää ◽  
R. Bloigu ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Large Body ◽  
Density Lipoprotein ◽  
Low Density ◽  
Salivary Iga ◽  
Coronary Syndrome ◽  
Healthy Humans ◽  
Iga Antibody ◽  
Oral Pathogens ◽  
Stable Cad

A large body of literature has established the link between periodontal disease and cardiovascular disease. Oxidized low-density lipoproteins (OxLDLs) have a crucial role in atherosclerosis progression through initiation of immunological response. Monoclonal IgM antibodies to malondialdehyde-modified low-density lipoprotein (MDA-LDL) and to malondialdehyde acetaldehyde–modified low-density lipoprotein (MAA-LDL) have been shown to cross-react with the key virulence factors of periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. We have previously shown that salivary IgA antibodies to MAA-LDL cross-react with P. gingivalis in healthy humans. In this study, we aim to assess whether oral mucosal immune response represented by salivary IgA to MAA-LDL and oral pathogens is associated with coronary artery disease (CAD). Also, the molecular mimicry through antibody cross-reaction between salivary IgA to MAA-LDL and oral pathogens was evaluated. The study subjects consisted of 451 patients who underwent a coronary angiography with no CAD ( n = 133), stable CAD ( n = 169), and acute coronary syndrome (ACS, n = 149). Elevated salivary IgA antibody levels to MAA-LDL, Rgp44 (gingipain A hemagglutinin domain of P. gingivalis), and Aa-HSP60 (heat shock protein 60 of A. actinomycetemcomitans) were discovered in stable-CAD and ACS patients when compared to no-CAD patients. In a multinomial regression model adjusted for known cardiovascular risk factors, stable CAD and ACS were associated with IgA to MAA-LDL ( P = 0.016, P = 0.043), Rgp44 ( P = 0.012, P = 0.004), Aa-HSP60 ( P = 0.032, P = 0.030), Tannerella forsythia ( P = 0.002, P = 0.004), Porphyromonas endodontalis ( P = 0.016, P = 0.020), Prevotella intermedia ( P = 0.038, P = 0.005), and with total IgA antibody concentration ( P = 0.002, P = 0.016). Salivary IgA to MAA-LDL showed cross-reactivity with the oral pathogens tested in the study patients. The study highlights an association between salivary IgA to MAA-LDL and atherosclerosis. However, whether salivary IgA to MAA-LDL and the related oral humoral responses play a causal role in the development in the CAD should be elucidated in the future.

scholarly journals Mutans Streptococcal Infection Induces Salivary Antibody to Virulence Proteins and Associated Functional Domains

2008 ◽  
Vol 76 (8) ◽  
pp. 3606-3613 ◽  
Author(s):  
R. D. Nogueira ◽  
W. F. King ◽  
G. Gunda ◽  
S. Culshaw ◽  
M. A. Taubman ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Mutans Streptococci ◽  
Enzyme Function ◽  
Antibody Activity ◽  
Sprague Dawley ◽  
Initial Exposure ◽  
Salivary Iga ◽  
Luminex Technology ◽  
Iga Antibody ◽  
Biofilm Development

ABSTRACTThe interplay between mucosal immune responses to natural exposure to mutans streptococci and the incorporation and accumulation of these cariogenic microorganisms in oral biofilms is unclear. An initial approach to explore this question would be to assess the native secretory immunity emerging as a consequence ofStreptococcus mutansinfection. To this end, we analyzed salivary immunoglobulin A (IgA) antibody to mutans streptococcal glucosyltransferase (Gtf) and glucan binding protein B (GbpB) and to domains associated with enzyme function and major histocompatibility complex (MHC) class II binding in two experiments. Salivas were collected from approximately 45-day-old Sprague-Dawley rats, which were then infected withS. mutansSJ32. Infection was verified and allowed to continue for 2 to 2.5 months. Salivas were again collected following the infection period. Pre- and postinfection salivas were then analyzed for IgA antibody activity using peptide- or protein-coated microsphere Luminex technology.S. mutansinfection induced significant levels of salivary IgA antibody to Gtf (P< 0.002) and GbpB (P< 0.001) in both experiments, although the levels were usually far lower than the levels achieved when mucosal immunization is used. Significantly (P< 0.035 toP< 0.001) elevated levels of postinfection salivary IgA antibody to 6/10 Gtf peptides associated with either enzyme function or MHC binding were detected. The postinfection levels of antibody to two GbpB peptides in the N-terminal region of the six GbpB peptides assayed were also elevated (P< 0.031 andP< 0.001). Interestingly, the patterns of the rodent response to GbpB peptides were similar to the patterns seen in salivas from young children during their initial exposure toS. mutans.Thus, the presence of a detectable postinfection salivary IgA response to mutans streptococcal virulence-associated components, coupled with the correspondence between rat and human mucosal immune responsiveness to naturally presented Gtf and GbpB epitopes, suggests that the rat may be a useful model for defining mucosal responses that could be expected in humans. Under controlled infection conditions, such a model could prove to be helpful for unraveling relationships between the host response and oral biofilm development.

Salivary IgA antibody to oral streptococcal antigens in predentate infants

1990 ◽  
Vol 5 (2) ◽  
pp. 57-62 ◽  
Author(s):  
Daniel J. Smith ◽  
William F. King ◽  
Martin A. Taubman
Keyword(s):  
Salivary Iga ◽  
Streptococcal Antigens ◽  
Iga Antibody
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