scholarly journals Effects of Euglena gracilis EOD-1 Ingestion on Salivary IgA Reactivity and Health-Related Quality of Life in Humans

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1144 ◽  
Author(s):  
Ken-ichi Ishibashi ◽  
Machiko Nishioka ◽  
Nobuteru Onaka ◽  
Madoka Takahashi ◽  
Daisuke Yamanaka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Euglena Gracilis ◽  
Health Related Quality ◽  
Salivary Iga ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related ◽  
Antibody Titers ◽  
Iga Antibody

Euglena gracilis EOD-1, a microalgal strain known for high yields of the β-1, 3-glucan paramylon, is suggested to function as a dietary fiber and enhance immunity. Here, we aimed to investigate the effects of E. gracilis EOD-1 biomass (EOD1BM) ingestion on immunoglobulin A (IgA) antibody titers in saliva, its reactivity, and the health-related quality of life (QOL) in humans. Reacting human immunoglobulin preparations and saliva with paramylon granules revealed the presence of anti-paramylon antibodies in the blood and saliva. We conducted a placebo-controlled, double-blind, crossover study involving 13 healthy subjects who ingested the placebo or EOD1BM for 4 weeks. Saliva was collected from each subject before and after ingestion, and IgA titers and E. gracilis EOD-1 paramylon (EOD1PM) reactivity were compared. In the EOD1BM Ingestion group, the anti-EOD1PM IgA content and titer increased after EOD1BM ingestion. No such change was observed in the Placebo group. Furthermore, the health-related QOL, especially mental health, increased in the EOD1BM Ingestion group. Thus, EOD1BM ingestion led to the production of paramylon (PM)-specific IgA antibody and increased salivary IgA antibody titers. We demonstrate that EOD1BM ingestion enhanced the immunity in the mucosal surface, evoked an antigen-specific response, and increased the health-related QOL, thereby contributing to health improvement.

scholarly journals Quality of Life and Health for Patients with Chronic Periodontitis: A Qualitative Study

2020 ◽  
Author(s):  
Jeehee Pyo ◽  
Ji-Hyun Lee ◽  
Mina Lee ◽  
Minsu Ock
Keyword(s):  
Quality Of Life ◽  
Periodontal Disease ◽  
Dental Care ◽  
Dental Health ◽  
The Elderly ◽  
Health Related Quality ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related

Abstract Background: Disease burden created by periodontal disease has been recognized as a global challenge. The burden of medical expenses is expected to increase continuously, parallel to the growth of the elderly population. Periodontal disease causes tooth loss if not treated early, and advanced periodontitis can cause a decline in chewing ability and word pronunciation as well as aesthetic function. These results diminish the health-related quality of life (QOL) for various populations, particularly the elderly, adults, pregnant women, and workers. Thus, not only is early detection and management of the disease necessary, but also a systematic strategy for the prevention of periodontal diseaseMethods: Adults 19 years of age or older diagnosed with chronic gingivitis (K05.1) or chronic periodontitis (K05.3) under the ICD-10 codes were selected to participate in the study. Among the patients visiting the dental outpatient department, the study participants were chosen for our sample. A total of 20 participants were informed of the purpose of the study and gave consent to participate in in-depth interviews.Results: The analysis results were summarized into the four upper categories of ‘Interfering Element for Dental Care,’ ‘Declined Quality of Life caused by Dental Disease,’ ‘Satisfaction Elements after Treatment of Dental Disease,’ ‘Improvements for Voluntary Dental Care.’ The treatment of periodontal disease has improved the health-related quality of life and enabled the participants to have positive health behaviors for dental care. Furthermore, they recognized the severity of periodontal disease and the importance of dental examinations. It enabled them to be aware of the need of societal effort for dental care awareness.Conclusions: This study was an in-depth examination of the health-related QOL of periodontal patients through qualitative research methodology. The experiences of periodontal disease identified by this study can not only help to assess the adequacy of the current dental health-related QOL assessment tools but also recognize unmet needs regarding periodontal disease and, ultimately, to raise the awareness of periodontal disease among the general public. Based on this research, we expect that research on health-related QOL on periodontal disease would expand and revitalize the dental health system and practices.

Development of a Situation-Specific Theory for Explaining Health-Related Quality of Life Among Older South Korean Adults With Type 2 Diabetes

2014 ◽  
Vol 28 (2) ◽  
pp. 113-126 ◽  
Author(s):  
Sun Ju Chang ◽  
Eun-Ok Im
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Health Related Quality ◽  
South Korean ◽  
Korean Adults ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related

The purpose of the study was to develop a situation-specific theory for explaining health-related quality of life (QOL) among older South Korean adults with type 2 diabetes. To develop a situation-specific theory, three sources were considered: (a) the conceptual model of health promotion and QOL for people with chronic and disabling conditions (an existing theory related to the QOL in patients with chronic diseases); (b) a literature review using multiple databases including Cumulative Index for Nursing and Allied Health Literature (CINAHL), PubMed, PsycINFO, and two Korean databases; and (c) findings from our structural equation modeling study on health-related QOL in older South Korean adults with type 2 diabetes. The proposed situation-specific theory is constructed with six major concepts including barriers, resources, perceptual factors, psychosocial factors, health-promoting behaviors, and health-related QOL. The theory also provides the interrelationships among concepts. Health care providers and nurses could incorporate the proposed situation-specific theory into development of diabetes education programs for improving health-related QOL in older South Korean adults with type 2 diabetes.

Tinnitus and Its Association With Mental Health and Health-Related Quality of Life in an Older Population: A Nationwide Cross-Sectional Study

2020 ◽  
pp. 073346482096651
Author(s):  
Hye-Min Park ◽  
Jinsei Jung ◽  
Jong-Koo Kim ◽  
Yong-Jae Lee
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Older People ◽  
Community Dwelling ◽  
Three Dimensions ◽  
Health Related Quality ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related

This study investigated the relationship of tinnitus with mental health and health-related quality of life (QoL) in older people. Data source included 5,129 community-dwelling men and women ≥60 years old from the Korean National Health and Nutrition Examination Survey. Tinnitus was categorized into three groups: normal, tolerable tinnitus, and annoying tinnitus. Mental health and health-related QoL were assessed according to three dimensions (depressive mood, psychological distress, and suicidal ideation) and five domains (impaired mobility, impaired self-care, impaired usual activities, pain/discomfort, and anxiety/depression). The odds ratios (ORs) and 95% confidence intervals (CIs) of mental health and health-related QoL were calculated using multiple logistic regression analyses. Annoying tinnitus was positively and independently associated with deteriorated mental health and health-related QoL, suggesting comprehensive care is needed in older people with annoying tinnitus.

360 Efficacy of CBT-I and its Components on Health-Related Quality of Life Outcomes in Older Adults

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A143-A144
Author(s):  
Kelly Showen ◽  
Kathleen O’Hora ◽  
Beatriz Hernandez ◽  
Laura Lazzeroni ◽  
Jamie Zeitzer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Older Adults ◽  
Health Related Quality ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related ◽  
The Impact ◽  
Over Time

Abstract Introduction Insomnia affects 30–48% of older adults and impairs health-related quality of life (HRQoL). Numerous studies report Cognitive Behavioral Therapy (CBT-I) as an effective non-pharmacological treatment for insomnia symptoms, with few examining the impact of CBT-I on mental and physical aspects of HRQoL. While limited research suggests that CBT-I leads to improvements in HRQoL, the impact of the cognitive versus behavioral components of CBT-I on HRQoL is unknown. Methods 128 older adults with insomnia (mean age=69, 66% female, 19% minority) were randomized to receive cognitive therapy (CT), behavior therapy (BT), or CBT-I. The Short Form (36) Health Survey (SF-36) was collected at baseline, post-treatment and six-month follow-up. Split-plot linear mixed models with age and sex as covariates to assess within and between subject changes were used to test intervention, time, and interaction effects on the mental health and physical well-being domains of HRQoL. Significance for all effects was defined as p < 0.05. The effect size (d) was calculated by dividing the difference between means by the root-mean-squared error of the mixed effects model. Results The mental health-related QoL improved over time independent of treatment (Main effect of time: F(2, 202) = 6.51, p < 0.002). The interaction failed to reach significance (Interaction: F(4, 202) = 1.19, p = .31). Simple effects revealed significant improvements among CBT-I participants at six months (p = .02, d = .53) and CT participants at post-treatment (p = .00, d = .79) and six months (p = .03, d = .66), but not among BT participants for either time point (p = .32, d = .24; p = .16, d = .35). Treatment did not improve physical health-related QoL over time (F(2, 202) = 1.01, p = .37) nor was there a significant interaction (F(4, 202) = .46, p = .76). Conclusion These findings suggest that CBT-I, particularly the CT component, may be effective in improving mental health-related QoL outcomes for older adults with insomnia. In contrast, neither CBT-I nor its component treatments were effective in improving physical health-related QoL. Support (if any) NIMHR01MH101468-01; Mental Illness Research, Education, and Clinical Center (MIRECC) at the VAPAHCS

scholarly journals Improved health-related quality of life in patients treated with topical sirolimus for facial angiofibroma associated with tuberous sclerosis complex

2020 ◽  
Author(s):  
Takashi Hatano ◽  
Yuki ohno ◽  
YU Imai ◽  
Jun Moritake ◽  
Katsuhisa Endo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Events ◽  
Health Related Quality ◽  
Sf 36 ◽  
Scale Scores ◽  
Gel Treatment ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related

Abstract Background : Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder forming hamartomas throughout the body. Facial angiofibromas (FAs) occur in 75% of TSC patients, which are often enlarged, impairing the appearance of the face, and reducing the patient's quality of life (QOL). The aim of this study was to characterize the impact of topical sirolimus treatment on the health-related QOL in patients with FA associated with TSC. Methods : We investigated a total of 33 patients who received sirolimus gel treatment for FA associated with TSC and assessed the changes in the health-related QOL using the Medical Outcomes Study 36-Item Short Form (SF-36) Health Survey. SF-36 surveys were performed before and after three months of treatment. The conditions of the patients after using the sirolimus gel were categorized into the following three categories: "improved," "unchanged," and "aggravated." Adverse events were investigated using the CTCAE v5.0-JCOG. Results : After 3 months of sirolimus gel treatment, three scale scores of the SF-36, vitality (VT), social function (SF), and mental health (MH), were significantly improved compared to before the treatment. The VT and SF in patients who had improved FA were significantly better than those in the other patients. There were no significant differences in any scale scores between patients with and without adverse events at three months after the initiation of sirolimus gel treatment. Conclusions : This is the first report regarding improved health-related quality of life in patients treated with sirolimus gel for FA associated with TSC by using the SF-36. The three scale scores associated with mental health were significantly improved compared to before the treatment. The health-related QOL in patients receiving sirolimus gel treatment is more strongly affected by the treatment efficacy than adverse events.

scholarly journals Assessment of Health-Related Quality of Life: The Cinderella of Peritoneal Dialysis?

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Mercedes Moreiras-Plaza ◽  
Raquel Blanco-García ◽  
Cinthya Raquel Cossio-Aranibar ◽  
Gloria Rodriguez-Goyanes
Keyword(s):  
Quality Of Life ◽  
Gradual Increase ◽  
Chronic Illnesses ◽  
Health Policies ◽  
Health Related Quality ◽  
Important Condition ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related

The studies of quality of life (QoL) are becoming increasingly interesting in clinical setting because their findings have implications for making decisions on resource allocation and health policies. The assessment of health-related QoL is especially directed to patients with chronic illnesses that cause progressive deterioration and limitations, and consume the bulk of financial resources for health. Among these chronic kidney disease and, more specifically the renal replacement therapy, is an important condition. Due to the diagnostic and therapeutic advances, we see a gradual increase both in the number of the dialysis population and its age, which leads to a growing interest in the study of these patients' QoL, as evidenced by more than one thousand articles published on this subject.

scholarly journals Improved health-related quality of life in patients treated with topical sirolimus for facial angiofibroma associated with tuberous sclerosis complex.

2020 ◽  
Author(s):  
Takashi Hatano ◽  
Yuki ohno ◽  
YU Imai ◽  
Jun Moritake ◽  
Katsuhisa Endo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Events ◽  
Health Related Quality ◽  
Sf 36 ◽  
Scale Scores ◽  
Gel Treatment ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related

Abstract Background: Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder forming hamartomas throughout the body. Facial angiofibromas (FAs) occur in 75% of TSC patients, which are often enlarged, impairing the appearance of the face, and reducing the patient's quality of life (QOL). The aim of this study was to characterize the impact of topical sirolimus treatment on the health-related QOL in patients with FA associated with TSC.Methods: We investigated a total of 33 patients who received sirolimus gel treatment for FA associated with TSC and assessed the changes in the health-related QOL using the Medical Outcomes Study 36-Item Short Form (SF-36) Health Survey. SF-36 surveys were performed before and after three months of treatment. The conditions of the patients after using the sirolimus gel were categorized into the following three categories: "improved," "unchanged," and "aggravated." Adverse events were investigated using the CTCAE v5.0-JCOG.Results: The median age of the patients was 25 (range 14-55) years. After 3 months of sirolimus gel treatment, three scale scores of the SF-36, vitality (VT), social function (SF), and mental health (MH), were significantly improved compared to before the treatment. The VT and SF in patients who had improved FA were significantly better than those in the other patients. There were no significant differences in any scale scores between patients with and without adverse events at three months after the initiation of sirolimus gel treatment.Conclusions: This is the first report regarding improved health-related quality of life in patients treated with sirolimus gel for FA associated with TSC by using the SF-36. The three scale scores associated with mental health were significantly improved compared to before the treatment. The health-related QOL in patients receiving sirolimus gel treatment is more strongly affected by the treatment efficacy than adverse events. Mini-abstractSirolimus gel treatment improves the health-related QOL in patients with FA associated with TSC.

scholarly journals Community Pharmacists’ Measurement of Health-related Quality of Life in Outpatients Taking High-risk Drugs

2021 ◽  
Author(s):  
Takenori Ichimura ◽  
Chiaki Ogawa ◽  
Hayato Murata ◽  
Katsuaki Miyahara ◽  
Satoshi Yuge ◽  
...  
Keyword(s):  
Quality Of Life ◽  
High Risk ◽  
Community Pharmacists ◽  
Normal Activity ◽  
Health Related Quality ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related ◽  
Average Health

Abstract Background: Patients who develop severe side-effects when taking high-risk drugs may have a significantly reduced health-related quality of life (QOL); therefore, it is important to identify changes in health-related QOL in these patients. This study aimed to determine health-related QOL in community pharmacy outpatients taking high-risk drugs.Methods: This prospective observational study was conducted at 29 pharmacies in 12 regions and cities in Japan from October to December 2020. Using descriptive questionnaires of EuroQOL-5-dimensions-5-levels (EQ-5D-5L), community pharmacists obtained health-related QOL data from outpatients taking high-risk drugs.Results: In total, 760 outpatients were enrolled. The mean health-related QOL of all outpatients was 0.869. Health-related QOL decreased with increasing age. Outpatient health -related QOL was 0.700, 0.763, 0.785, and 0.817 when taking antiepileptic, antidepressant, digitalis, and antiarrhythmic drugs, respectively, which was lower than the average health-related QOL of all outpatients. Mobility and pain/discomfort accounted for a large proportion of the decline in health-related QOL with increasing age. No difference was found concerning personal care in relation to age; however, the number of outpatients with mobility, normal activity, and pain challenges decreased with age. In contrast, outpatients aged <65 years with anxiety/depression showed lower than overall average health-related QOL.Conclusion: Community pharmacists determined the health-related QOL of outpatients taking high-risk drugs. We clarified the contributions of the 5-dimensions.Trial registration: UMIN-CTR Study Design: trial Number UMIN 000041942. Registered 30 September 2020, https://www.umin.ac.jp

scholarly journals Health and health-related quality of life in pig farmers carrying livestock-associated methicillin-resistantStaphylococcus aureus

2016 ◽  
Vol 144 (8) ◽  
pp. 1774-1783 ◽  
Author(s):  
B. A. G. L VAN CLEEF ◽  
B. H. B. VAN BENTHEM ◽  
E. J. M. VERKADE ◽  
M. M. L. VAN RIJEN ◽  
M. F. Q. KLUYTMANS-VAN DEN BERGH ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Environmental Samples ◽  
Health Related Quality ◽  
Sf 36 ◽  
Nasal Swabs ◽  
Health Related Qol ◽  
Related Quality ◽  
Health Related ◽  
The Impact

SUMMARYThere is limited knowledge about the effect of livestock-associated methicillin-resistantStaphylococcus aureus(LA-MRSA) carriage on health-related quality of life (QoL). With this study, we explored whether LA-MRSA causes infections or affects health-related QoL in pig farmers. This prospective cohort study surveyed persons working on 49 farrowing pig farms in The Netherlands for 1 year (2010–2011). On six sampling moments, nasal swabs, environmental samples and questionnaires on activities and infections were collected. At the end of the study year, persons were asked about their QoL using the validated SF-36 and EQ-5D questionnaires. Of 120 persons, 44 (37%) were persistent MRSA carriers. MRSA carriage was not associated with infections, use of antimicrobials, healthcare contact and health-related QoL items in univariate or multivariate analysis, most likely due to the ‘healthy worker effect’. Despite high carriage rates, the impact of LA-MRSA carriage in this population of relatively healthy pig farmers on health and health-related QoL appears limited; more research is needed for confirmation.

Sign in / Sign up

Export Citation Format

Share Document