scholarly journals Effects of Chronic Use of Methylphenidate on Spermatogenesis and Sexual Hormones in Adult Male Rats

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Alireza Akhavan Rezayat ◽  
Amir Abbas Asadpour ◽  
Samaneh Boroumand Noughabi ◽  
Hassan Ahmadnia ◽  
Hamid Mohseni ◽  
...  
Keyword(s):  
Body Weight ◽  
Sperm Count ◽  
Total Body Weight ◽  
Male Rats ◽  
Control Group ◽  
Testis Weight ◽  
Control Groups ◽  
Major Health Problem ◽  
Total Body ◽  
And Control

Background: The growing prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and the non-medical use of Methylphenidate (MPH) among the youth have lead male infertility to be a major health problem. Objectives: The present study was conducted to investigate the impacts of MPH administration on different aspects of productivity, including total body weight, testis weight, spermatogenesis, sperm motility, histopathology changes, and sex hormone serum levels in male rats. Methods: This study was performed with 54 eight-week-old male rats divided into one control and two experimental groups. The experimental groups were gavaged with 2 and 10 mg/kg methylphenidate daily while the control group was gavaged with normal saline (at the same dosage). After 60 days, rats were subjected to blood sampling and bilateral orchidoepididymectomy under anesthesia. Spermogram, histological, and hormonal evaluations were performed on the samples. Testes weight and total body weight were also recorded. Results: The results revealed significant differences between the MPH and experimental groups in terms of hormonal, spermographic, and histopathologic features, as well as weight. Luteinizing hormone and testosterone levels, sperm count and motility, Leydig cell hyperplasia, spermatogenesis, congestion and necrosis levels, total body weight, and testis weight were significantly different between the experimental and control groups. However, no difference was observed between the experimental and control groups concerning follicle-stimulating hormone, maturation arrest, and edema levels. Conclusions: Based on the findings, MPH exposure exerts a significant effect on the testis and total body weight, as well as hormonal, spermatographic, and histopathologic characteristics. Accordingly, the present study provided an insight into the negative impression of MPH on sexual parameters.

Dietary fat and adiposity: a dose-response relationship in adult male rats fed isocalorically

1995 ◽  
Vol 268 (4) ◽  
pp. E546-E550 ◽  
Author(s):  
C. N. Boozer ◽  
G. Schoenbach ◽  
R. L. Atkinson
Keyword(s):  
Body Weight ◽  
Body Fat ◽  
Adult Male ◽  
Dietary Fat ◽  
Male Rats ◽  
Control Group ◽  
Low Fat Diet ◽  
Mesenteric Fat ◽  
Total Body Fat ◽  
Total Body

This study examined the effects of increasing levels of dietary fat fed isocalorically on body weight, body composition, and adipose distribution. Adult male rats were weight matched into four groups. One group that was fed a low-fat diet (12%) served as reference controls. The other three groups were fed diets of 24, 36, or 48% fat in amounts to equal the energy intake of the control group. After 6 wk, body weights of the four groups were not significantly different. Intrascapular brown fat did not differ between groups. Total body fat and adipose depot weights, however, increased in proportion to the level of fat in the diet. Total body fat and retroperitoneal and mesenteric depot weights of the 48% fat group were greater than controls (P < 0.05). Mesenteric fat in this group was also significantly increased over all other groups (P < 0.05). These results show that high-fat diets fed to adult animals cause increased body fat in the absence of significant changes in body weight and that mesenteric fat is increased disproportionately.

EFFECTS OF TESTOSTERONE MEDIATED OR MODULATED BY PITUITARY FACTORS

1975 ◽  
Vol 67 (1) ◽  
pp. 71-79 ◽  
Author(s):  
P. DE MOOR ◽  
M. ADAM-HEYLEN ◽  
H. VAN BAELEN ◽  
G. VERHOEVEN
Keyword(s):  
Body Weight ◽  
Testosterone Propionate ◽  
Total Body Weight ◽  
Seminal Vesicles ◽  
Female Rats ◽  
Male Rats ◽  
Intact Male ◽  
Adult Rats ◽  
Organ Weights ◽  
Total Body

SUMMARY Adult rats of both sexes were either gonadectomized or hypophysectomized and gonadectomized. Three to eight weeks later they were treated for 14 consecutive days with oil or with 75 or 200 μg testosterone propionate (TP) per 100 g body weight. The animals were killed and for each sex the gonadectomized animals were compared with the hypophysectomized-gonadectomized animals as far as their NADPH- and NADH-dependent 3α-hydroxysteroid dehydrogenases (3α-HSD) in renal microsomes, transcortin levels in serum and five organ weights relative to total body weight were concerned. For two of the latter, i.e. the relative kidney and prostatic weights, no significant differences were found. Transcortin levels, relative adrenal weights and renal NADPH-dependent 3α-HSD activities were higher in oil-treated gonadectomized animals than in oil-treated hypophysectomized-gonadectomized animals. The opposite was found for the relative weights of uterus and seminal vesicles and renal NADH-dependent 3α-HSD activities. These differences between gonadectomized and hypophysectomized-gonadectomized animals disappeared after TP treatment as far as transcortin levels were concerned but remained for the five other parameters. After gonadectomy sexual differences subsisted for all parameters studied. But whereas intact male rats had higher NADH-dependent 3α-HSD activities than female rats the opposite was found after gonadectomy. After gonadectomy plus hypophysectomy the between sex differences disappeared as far as transcortin levels were concerned but remained in the other parameters studied.

The influence of injectable sodium selenite on semen characteristics and testosterone concentration in Aardi goats

2015 ◽  
Vol 49 (6) ◽  
Author(s):  
A. Hajalshaikh ◽  
M. J. Al-Hassan ◽  
H. E. Mohamed
Keyword(s):  
Body Weight ◽  
Sodium Selenite ◽  
Semen Quality ◽  
Sperm Count ◽  
Plasma Concentrations ◽  
Control Group ◽  
Progressive Motility ◽  
Group I ◽  
Semen Characteristics ◽  
And Control

The objective of this study was to test the effects of sodium selenite (SS) injection on semen characteristics and testosterone plasma concentrations in male Aardi goats. Fifteen animals were assigned into three groups; control (group I, with no supplemental SS); group II; injected intramuscular with 0.1 mg/kg SS body weight; group III injected 0.05 mg/kg SS body weight. Blood samples were collected once weekly (week 0 and four weeks after treatment) in the morning (at 8 am). Semen was collected by electro-ejaculator on a weekly basis post SS supplementation. Sperm count, motility %, progressive motility characteristic; average path velocity (VAP), straight line velocity (VSL), curvilinear velocity (VCL), straightness (STR) and linearity (LIN) were analyzed. Significant differences were found between the two treated-groups and control after week four for motility and progressive motility. After five weeks, significant differences were found between groups, for motility and progressive motility. The live % showed significant differences after five weeks between treated and control groups. After five weeks, significant differences were found between the three groups, for motility and progressive motility. The live % showed significant differences after 5 weeks between different treatments. However, VAP, VSL, VCL, STR, and LIN showed non-significant differences, suggesting that bucks might already have a good motility characteristic. No significant effects of SS supplementation on testosterone plasma levels, and the reported values were 1.28; 1.35, and 1.36 ng/ml for control; group 1, and group 2; respectively. In conclusion, SS improved reproduction in goats <italic>via</italic> the enhancement of semen quality in Aardi goats.

La fraye d'une population d'éperlans géants, Osmerus eperlanus mordax, au lac Heney, Comté de Gatineau, Québec

1968 ◽  
Vol 25 (9) ◽  
pp. 1813-1830 ◽  
Author(s):  
Roméo-O. Legault ◽  
Claude Delisle
Keyword(s):  
Body Weight ◽  
Total Body Weight ◽  
The Body ◽  
Testis Weight ◽  
Spawning Period ◽  
Weight One ◽  
Total Body ◽  
Set Up ◽  
The Right ◽  
Two Populations

Two sympatric smelt populations inhabit Lake Heney, Gatineau County, Quebec. This study deals only with the population which we call "giant" but a brief discussion on "small smelt — large smelt" theory is included. The data were obtained from 1556 specimens collected with eight gillnets set up under the ice at one locality on Lake Heney, in February, March, and April 1967. The data permitted the determination of the time and site of spawning in the giant population. The time and site of spawning in the "dwarf" population was already known, and we found a marked difference in the spawning behavior and time of spawning of the two populations. The two populations are furthermore reproductively isolated. The sex ratio during the spawning period was closely followed and found to be similar to that of all other freshwater or marine smelts. A DeGiusti dredge, dragged along the bottom below the position of the gillnets immediately after the melting of the ice, permitted the collection of embryonic smelt eggs from a depth of 30–40 ft.The maturity index, relative fecundity, and intergonadal ratio were especially studied. Ovary weight at maturity represents in average one-quarter the total body weight, and testis weight one-fortieth the body weight. A 213-mm female lays an average of 42,460 eggs. The right ovary is 4.5 times smaller than the left one, and the right testis is on the average 3.8 times smaller than the left one.There is a direct relationship between total fecundity and length of mature females. This relation is expressed by the curve log E = 4.54 log L + k.

STUDIES ON THE EFFECT OF HORMONE ADMINISTRATION ON BODY WEIGHT AND ON TIBIAL EPIPHYSIAL CARTILAGE WIDTH IN INTACT, HYPOPHYSECTOMIZED AND ADRENALECTOMIZED RATS

1963 ◽  
Vol 25 (4) ◽  
pp. 473-482 ◽  
Author(s):  
HELEN E. C. CARGILL THOMPSON ◽  
G. P. CREAN
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Young Male ◽  
Total Body Weight ◽  
Male Rats ◽  
Unilateral Nephrectomy ◽  
Hormone Administration ◽  
Epiphysial Cartilage ◽  
Hypophysectomized Rats ◽  
Total Body

SUMMARY 1. The effects of feeding, hormone administration, unilateral nephrectomy and adrenalectomy on width of tibial cartilage and total body weight in intact and hypophysectomized young male rats were measured. 2. Unilateral nephrectomy and adrenalectomy have no effect on the cartilage width of both intact and hypophysectomized rats, although adrenalectomy causes a loss in weight in the intact rat. 3. Intact rats, both young and adult, fed enough to maintain but not to put on weight, show a reduction of cartilage width to hypophysectomized levels. 4. Growth hormone alone (1 mg. and 3 mg./day for 14 days) causes a marked increase in cartilage width but only a 50–60% increase in total body weight in the hypophysectomized rat. 5. Adrenocorticotrophin (ACTH: 2 i.u./day for 14 days) causes a significant reduction in both cartilage width and total body weight in the hypophysectomized rat. 6. Thyrotrophin (TSH: 1 i.u./day) and Prolactin (1 mg. and 2 mg./day) caused significant increases in both total body weight and cartilage width in the hypophysectomized rat. 7. Luteinizing hormone (LH: 0·01 mg./day) together with follicle stimulating hormone (FSH: 1·0 mg./day) caused a significant increase in body weight, but had no effect on cartilage width in the hypophysectomized rat. 8. Both doses of combined hormones (growth hormone, ACTH, TSH, prolactin, FSH and LH administered together) caused a marked increase in cartilage width and a smaller increase in total body weight in the hypophysectomized rat.

scholarly journals Water sprinkling as a tool for heat abatement in farmed Iberian red deer: Effects on calf growth and behaviour

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249540
Author(s):  
F. J. Pérez-Barbería ◽  
I. Arroyo-González ◽  
A. J. García ◽  
M. P. Serrano ◽  
L. Gallego ◽  
...  
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Red Deer ◽  
Control Group ◽  
Control Groups ◽  
Similar Time ◽  
Control Male ◽  
Calf Growth ◽  
Iberian Red Deer ◽  
And Control

Climatic models predict scenarios in which ambient temperature will continue increasing worldwide. Under these climatic conditions, fitness and animal welfare of many populations are expected to suffer, especially those that live in captive or semi-natural conditions, where opportunities of heat abatement are limited. We undertook an experimental design to assess the effect of heat abatement that water sprinkling might have on Iberian red deer calf growth and behaviour from birth to weaning (135 days). One group of ten mother-calf pairs lived on plots with water sprinkling (treatment) available during summer’s hottest time of the day, while the control group (nine mother-calf pairs) occupied plots with no available water sprinkling. Treatment and control groups were fed ad libitum and swapped between plots every seven days to minimise any plot effect. Body weight was monitored weekly and individual behaviour was recorded once or twice a week at mid-day. We observed that calves had showers under the sprinklers and wallowed in mud puddles. The results clearly indicated that calves of the treatment group showed a significant increase in body weight at weaning in comparison with the control group, with no differences between sexes (treatment: male = 56.5 kg, female = 50.3 kg; control: male = 50.3 kg, female = 46.5 kg). Mother weight and mother age effects were negligible on calf body weight at weaning. The heavier the mother the faster was the rate of growth of its offspring, irrespective of calf sex. The model indicated that although males grew significantly slower than female calves in the control group, males grew faster than females when exposed to the treatment. Calves of the treatment group spent less time drinking, less time in the shade, similar time eating and more time in motion than calves of the control group. There were no behavioural differences between calf sexes of treatment and control groups. The results indicate the importance of providing animals with opportunities of heat abatement in hot environments to improve animal growth and welfare in farmed Iberian red deer.

scholarly journals Effectiveness of Forgiveness Skill on Worry and Hopelessness in Women Victims of Sexual Abuse in Childhood

2019 ◽  
pp. 1-6
Author(s):  
Shahrbanoo Ghahari ◽  
Neda Naeimi ◽  
Zahra Azemnia ◽  
Mohammad Mazloumirad ◽  
Susan Salari ◽  
...  
Keyword(s):  
Sexual Abuse ◽  
Women Victims ◽  
Test Group ◽  
Control Group ◽  
Control Groups ◽  
Major Health Problem ◽  
Major Health ◽  
Group Members ◽  
Victims Of Sexual Abuse ◽  
And Control

Sexual abuse is a major health problem and trauma if encountered in childhood. This study was conducted about the Effectiveness, Forgiveness skill on worry and hopelessness in Women Victims of sexual abuse in childhood. This is a semi-experimental study with pretest-posttest as well as control and test groups. 30 depressed women who reported a sexual abuse by relative and referred to several psychological clinics in Tehran in 2017 were studied. Studied sample consisted of 30 women who were selected randomly (how the author has used random sampling) (the author should have used purposive sampling rather than random) and signed into two 15-member experimental and control groups. Sample members of test group were under intervention individually within 12 sessions with forgiveness approach and control group members were remained in waiting list. Both of groups filled out worry and hopelessness scale   in baseline and after intervention. The data were analyzed using covariance analysis through IBM SPSS 22.0 software. Results obtained from study indicate difference between worry and hopelessness level of women victims of sexual abuse in control and experimental groups after forgiveness training. Forgiveness skill is effective in reducing worry and hopelessness in women victims of sexual abuse in childhood.

Body Weight and Blood Biochemical Changes Following Nutritional Supplementation in Prepubertal Jaffrabadi Buffalo (Bubalus bubalis) Heifers

2019 ◽  
Vol 15 (01) ◽  
pp. 50-54
Author(s):  
R J Raval1 ◽  
K B Vala ◽  
V A Kalariya ◽  
A J Dhami ◽  
F S Kavani
Keyword(s):  
Body Weight ◽  
Bubalus Bubalis ◽  
Biochemical Changes ◽  
The Body ◽  
Nutritional Supplementation ◽  
Monthly Interval ◽  
Control Group ◽  
Control Groups ◽  
Blood Biochemical ◽  
And Control

The high plan of nutrition right from an early age is believed to enhance ovarian activity and early onset of puberty in heifers. This study was therefore conducted to know the body weight, ovarian and blood biochemical changes in nutritionally supplemented and control groups of prepubertal Jaffrabadi buffalo (Bubalus bubalis) heifers. A total of 12 animals of 30 ± 2 month's age and the identical body weight of 380–410 kg from Cattle Breeding Farm, JAU, Junagadh were utilized for this study. They were randomly divided into two equal groups of 6 animals in each treatment and control groups. The heifers of the treatment group were supplemented with bypass fat (100 g), bypass protein (950 g) and chelated mineral mixture (50 g) over the routine farm feeding practices of control group, and its effect on body weight gain and blood biochemical profiles were studied at a monthly interval during 6 months of experimental period. The overall effect of nutritional supplementation on animals body weight, blood glucose and total cholesterol over the control group was statistically non-significant (p greator than 0.05) yet beneficial. The plasma total protein levels in the supplemented group increased with a duration of supplement and levels were significantly (p less than 0.05) higher over the control group. The ovarian dynamics evaluated by transrectal ultrasound during last three months of the study revealed an increasing number of growing follicles greator than 4 mm in diameters (5.00 ± 0.13 to 6.67 ± 0.40), without significant variation in diameters of largest follicles (9.14 ± 0.45 to 10.27 ± 0.85 mm) between groups or periods. However, none of the heifers exhibited behavioral signs of estrus during 6 months study, in spite of the establishment of cyclicity with the presence of developed follicles, or CLs suggesting silent ovulation, at 36 ± 2 months of age in this breed.

scholarly journals THE INFLUENCE OF ANEMIA ON PHAGOCYTIC FUNCTIONS AND RESISTANCE TO INFECTION IN MICE

Blood ◽  
1947 ◽  
Vol 2 (Special_Issue_Number_1) ◽  
pp. 117-124 ◽  
Author(s):  
L. JOE BERRY ◽  
EVELYN C. HALLER
Keyword(s):  
Body Weight ◽  
Survival Rate ◽  
Blood Loss ◽  
Salmonella Typhimurium ◽  
Total Body Weight ◽  
Control Group ◽  
Phagocytic Function ◽  
Progressive Development ◽  
Resistance To Infection ◽  
Total Body

Abstract The increase in phagocytic function of neutrophiles of mice was measured during the progressive development of anemia due to blood loss. The animals were bled from the tail, 2 per cent of total body weight being removed twice weekly for nine bleedings. Phagocytosis was 161 per cent of normal at the end of this period, and the erythrocyte totals and hemoglobin values were approximately two thirds of normal. The anemic mice were infected intraperitoneally with a suspension of Salmonella typhimurium and their survival rate was compared with normal mice similarly infected. Twenty-eight of 63 anemic mice survived and 14 of 63 normal mice survived. In a second experiment, mice were subjected to bleeding every third day for nine bleedings, and were then infected along with a control group. One half of the anemic animals were bled for three additional bleedings after the infection. Two of 48 control animals survived, 5 of 47 anemic mice, additionally bled, survived, and 19 of 47 anemic mice, not bled after infection, survived. This suggests that the increase in phagocytosis that accompanies anemia may be, at least in part, responsible for the increased resistance to infection.

scholarly journals The Effect of Feeding with Resveratrol on Myogenin and mTOR Levels in Mice

2020 ◽  
pp. 1-6
Author(s):  
Serap Andaç Öztürk ◽  
Gül Kızıltan ◽  
Erkan Yurtçu ◽  
Didem Bacanlı ◽  
Yeşim Korkmaz Kasap ◽  
...  
Keyword(s):  
Body Weight ◽  
Muscle Mass ◽  
Muscle Hypertrophy ◽  
Total Body Weight ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Time Interval ◽  
Study Group ◽  
Total Body ◽  
The Right

Aim: It is reported that resveratrol may induce muscle hypertrophy and myogenesis. Accordingly, resveratrol is promising for the treatment of muscle diseases and ergogenic aid for athletes. In this study it is aimed to observe the effects of resveratrol on myogenin and mTOR levels and muscle mass. Material and Methods: The study is performed on 14 Swiss albino young adult mice at Başkent University Experimental Animal Research Center. The mice are divided randomly into study (n:7) and control (n:7) groups. During consecutive 7 days, 20 mg/kg trans-resveratrol was given to the study group intraperitoneally. After the seventh day administration, the right gastrocnemius muscles are disected, weighted and stored at -80 °C for mTOR and myogenin analysis. Then, myogenin and mTOR levels are determined by enzyme-linked immunosorbent assay (ELISA) method in homogenised muscle mass. Results: According to mean myogenin and mTOR levels, there was no significantly difference between groups (p>0.05). Total body weight and the right gastrocnemius muscle weight of the study group (22.11±3.22 g, 0.09±0.03 g, respectively) at the 7th day was found significantly lower than control group (28.63±3.80 g, 0.12±0.02 g, respectively) (p<0.05). Conclusion: It was observed that resveratrol administration had no effect on myogenin and mTOR levels which is a fore-step for muscle hypertrophy. On the other hand, interestingly total body weight and muscle mass decrease was observed in the study group. The effects of resveratrol on muscle tissue is a relatively less studied topic. However, the authors are suggesting more studies on the resveratrol usage or administration for the effective dose and time interval investigation.

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