scholarly journals Assessment of the Characteristics of Different Kinds of MS Lesions Using Multi-Parametric MRI

2020 ◽  
Vol 7 (4) ◽  
Author(s):  
Asieh Fatemidokht ◽  
Mohammad Hossein Harirchian ◽  
Elham Faghihzadeh ◽  
Abbas Tafakhori ◽  
Mohammad Ali Oghabian
Keyword(s):  
Cerebral Blood Volume ◽  
Magnetization Transfer ◽  
High Sensitivity ◽  
Brain Lesions ◽  
Quantitative Mri ◽  
Tissue Loss ◽  
Magnetization Transfer Ratio ◽  
Post Contrast ◽  
Fluid Attenuated Inversion Recovery ◽  
Best Parameter

Background: Studying different pathological aspects of lesions in multiple sclerosis (MS) patients could be useful to modify the diagnosis and treatment of this neurological disorder. Magnetic resonance imaging (MRI) modalities have the potential to investigate variations in brain tissue because of inflammatory and neurodegenerative processes in various types of MS-related lesions. Objectives: This study was done to investigate the quantitative changes in MRI-based parameters, like perfusion and magnetization transfer ratio (MTR) of different types of brain lesions, to demonstrate the ability of MRI to detect structural and pathological differences in MS lesions. Methods: Quantitative MRI modalities were performed on 18 patients with five different kinds of lesions (T1 holes, acute and chronic white matter (WM), and acute and chronic gray matter (GM) lesions) using a 3 T MRI scanner. The following protocols were used to characterize the pathology of lesions: (I) fluid-attenuated inversion recovery (FLAIR); (II) pre- and post-contrast T1-weighted; (III) dynamic contrast-enhanced (DCE); and (IV) MTR imaging. Quantitative comparison of Ktrans, cerebral blood volume (CBV), cerebral blood flow (CBF), and MTR was done to find the best parameter to distinguish different lesions. Finally, a multivariate classifier was applied to introduce the best parameter to indicate differences in lesions. Results: Five lesions were characterized by perfusion and MTR parameters. The pathological changes were measured, including: (I) the highest value of parameters in both acute WM and GM lesions; (II) the lowest value of four parameters in both chronic WM and GM lesions; (III) MTR had the highest rank among parameters using the classifier. Conclusions: The degree of pathological alterations due to inflammatory and neurodegenerative processes in MS-related lesions was indicated through the used parameters in different kinds of lesions. Inflammation was the dominant process in acute lesions, while neurodegeneration and tissue loss were observed mostly in chronic lesions. Both inflammation and neurodegeneration were detected in T1 holes. Perfusion parameters and MTR were reasonable parameters to describe differences in brain lesions. Thus, it could be confirmed that magnetization transfer imaging (MTI) and DCE-MRI are high-sensitivity methods to detect microstructural changes in the brain and subtle changes in the blood-brain-barrier. Classification of the parameters indicated that MTR was the best biomarker than others to show variations in lesions pathology.

scholarly journals MRI of the corpus callosum in multiple sclerosis: association with disability

2010 ◽  
Vol 16 (2) ◽  
pp. 166-177 ◽  
Author(s):  
A. Ozturk ◽  
SA Smith ◽  
EM Gordon-Lipkin ◽  
DM Harrison ◽  
N. Shiee ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
Magnetization Transfer ◽  
Quantitative Mri ◽  
Magnetization Transfer Ratio ◽  
Lesion Volume ◽  
Impaired Performance ◽  
Disability Status ◽  
Axon Damage

Inflammatory demyelination and axon damage in the corpus callosum are prominent features of multiple sclerosis (MS) and may partially account for impaired performance on complex tasks. The objective of this article was to characterize quantitative callosal MRI abnormalities and their association with disability. In 69 participants with MS and 29 healthy volunteers, lesional and extralesional callosal MRI indices were estimated via diffusion tensor tractography. expanded disability status scale (EDSS) and MS functional composite (MSFC) scores were recorded in 53 of the participants with MS. All tested callosal MRI indices were diffusely abnormal in MS. EDSS score was correlated only with age (r = 0.51). Scores on the overall MSFC and its paced serial auditory addition test (PASAT) and 9-hole peg test components were correlated with callosal fractional anisotropy (r = 0.27, 0.35, and 0.31, respectively) and perpendicular diffusivity (r = —0.29, —0.30, and —0.31) but not with overall callosal volume or callosal lesion volume; the PASAT score was more weakly correlated with callosal magnetization-transfer ratio (r = 0.21). Anterior callosal abnormalities were associated with impaired PASAT performance and posterior abnormalities with slow performance on the 9-hole peg test. In conclusion, abnormalities in the corpus callosum can be assessed with quantitative MRI and are associated with cognitive and complex upper-extremity dysfunction in MS.

scholarly journals Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Stephanie B. Syc ◽  
Daniel M. Harrison ◽  
Shiv Saidha ◽  
Michaela Seigo ◽  
Peter A. Calabresi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Healthy Volunteers ◽  
Cognitive Dysfunction ◽  
Diffusion Tensor ◽  
Magnetization Transfer ◽  
Mean Diffusivity ◽  
Brain Structures ◽  
Quantitative Mri ◽  
Magnetization Transfer Ratio

Objective. To characterize MR signal changes associated with tissue damage in the fornix and cingulum in multiple sclerosis (MS) using quantitative MRI measures and to determine associations with cognitive dysfunction.Background. The fornix and cingulum are white-matter bundles that carry information related to cognition. While cognitive dysfunction is reported in 40–60% of MS patients, the neuroanatomical correlates of cognitive impairment remain incompletely understood.Methods. The cingulum, pillars of the fornix, and corticospinal tract were segmented by fiber tracking via diffusion tensor imaging. Average tract-specific fractional anisotropy (FA), mean diffusivity (MD), and magnetization transfer ratio (MTR) were compared in MS cases and healthy volunteers. Associations with clinical measures and neuropsychological tests were derived by multivariate linear regression.Results. Fornix FA (P=0.004) and MTR (P=0.005) were decreased, and fornix MD (P<0.001) and cingulum MD (P<0.001) increased, in MS cases (n=101) relative to healthy volunteers (n=16) after adjustment for age and sex. Lower fornix FA and MTR, and higher fornix MD andλ∥, were correlated with lower PASAT-3 scores, but not with slower 25FTW times. Lower PASAT-3 scores were associated with lower cingulum FA and higher MD andλ⊥.Conclusions. Cognitive dysfunction in MS may involve damage to a widespread network of brain structures, including white-matter pathways within the limbic system.

scholarly journals Preliminary Observations on Sensitivity and Specificity of Magnetization Transfer Asymmetry for Imaging Myelin of Rat Brain at High Field

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jae-Woong Kim ◽  
Jiye Choi ◽  
Janggeun Cho ◽  
Chulhyun Lee ◽  
Daejong Jeon ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Clinical Application ◽  
Sensitivity And Specificity ◽  
Gray Matter ◽  
High Field ◽  
Magnetization Transfer ◽  
High Sensitivity ◽  
Magnetization Transfer Ratio ◽  
Myelin Imaging

Magnetization transfer ratio (MTR) has been often used for imaging myelination. Despite its high sensitivity, the specificity of MTR to myelination is not high because tissues with no myelin such as muscle can also show high MTR. In this study, we propose a new magnetization transfer (MT) indicator, MT asymmetry (MTA), as a new method of myelin imaging. The experiments were performed on rat brain at 9.4 T. MTA revealed high signals in white matter and significantly low signals in gray matter and muscle, indicating that MTA has higher specificity than MTR. Demyelination and remyelination studies demonstrated that the sensitivity of MTA to myelination was as high as that of MTR. These experimental results indicate that MTA can be a good biomarker for imaging myelination. In addition, MTA images can be efficiently acquired with an interslice MTA method, which may accelerate clinical application of myelin imaging.

scholarly journals T2* dynamic contrast enhanced MR perfusion for cervical cord lesions; does it work?

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Mohamed Saied Abdelgawad ◽  
Mohamed Ihab Samy Reda ◽  
Nermeen Abd El-Monsef Abd El-Maaboud
Keyword(s):  
Cerebral Blood Volume ◽  
Clinical Laboratory ◽  
Laboratory Data ◽  
High Sensitivity ◽  
Cervical Cord ◽  
Histopathological Diagnosis ◽  
Mr Perfusion ◽  
Post Contrast ◽  
Inflammatory Lesions ◽  
Neoplastic Lesions

Abstract Background The goal of this work was to assess the value of magnetic resonance (MR) perfusion in narrowing the differential diagnosis of cord lesions. Thirty eight patients with different cervical cord lesions were involved in this study. This includes 20 males and 18 females, ranging between 13 and 60 years old. Conventional MR with T2W (axial and sagittal) and pre and post contrast T1W (axial and sagittal) in addition to the T2* MR perfusion sequence were done. The final diagnosis of cervical cord tumors was achieved by biopsy and histopathological diagnosis, while inflammatory lesions were proved by clinical, laboratory data and follow-up for six months. Results Neoplastic lesions were found in 13 patients, while 25 patients had inflammatory lesions. Relative cord/cerebral blood volume (rCBV) was significantly higher in neoplastic lesions when compared to non-neoplastic ones (2 ± 1.13 vs 1.01 ± 0.62), respectively. A cutoff value of 1.38 or higher has high sensitivity of 78% and specificity of 83% in differentiating between these lesions. Conclusion T2* is a valuable technique in differentiating neoplastic from non-neoplastic cervical cord lesions.

Clinically benign multiple sclerosis despite large T2 lesion load: Can we explain this paradox?

2007 ◽  
Vol 14 (2) ◽  
pp. 205-211 ◽  
Author(s):  
S. Strasser-Fuchs ◽  
C. Enzinger ◽  
S. Ropele ◽  
M. Wallner ◽  
F. Fazekas
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Brain Plasticity ◽  
Magnetization Transfer ◽  
Brain Parenchyma ◽  
Quantitative Mri ◽  
Resonance Spectroscopy ◽  
Magnetization Transfer Ratio ◽  
Lesion Load ◽  
Brain Parenchymal

Magnetic resonance imaging (MRI) techniques such as magnetization transfer imaging and magnetic resonance spectroscopy (MRS) may reveal otherwise undetectable tissue damage in multiple sclerosis (MS) and can serve to explain more severe disability than expected from conventional MRI. That an inverse situation may exist where non-conventional quantitative MRI and MRS metrics would indicate less abnormality than expected from T2 lesion load to explain preserved clinical functioning was hypothesized. Quantitative MRI and MRS were obtained in 13 consecutive patients with clinically benign MS (BMS; mean age 44 ± 9 years) despite large T 2 lesion load and in 15 patients with secondary progressive MS (SPMS; mean age 47 ± 6 years) matched for disease duration. The magnetization transfer ratio (MTR), magnetization transfer rate ( kfor), brain parenchymal fraction (BPF) and brain metabolite concentrations from proton MRS were determined. BMS patients were significantly less disabled than their SPMS counterparts (mean expanded disability status score: 2.1 ± 1.1 versus 6.2 ± 1.1; P < 0.001) and had an even somewhat higher mean T2 lesion load (41.2 ± 27.1 versus 27.9 ± 24.8 cm3; P = 0.19). Normal appearing brain tissue histogram metrics for MTR and kfor, mean MTR and kfor of MS lesions and mean BPF were similar in BMS and SPMS patients. Levels of N-acetyl-aspartate, choline and myoinositol were comparable between groups. This study thus failed to explain the preservation of function in our BMS patients with large T2 lesion load by a higher morphologic or metabolic integrity of the brain parenchyma. Functional compensation must come from other mechanisms such as brain plasticity. Multiple Sclerosis 2008; 14: 205—211. http://msj.sagepub.com

Contrast-Enhanced MRI with Magnetization Transfer Effect in the Imaging of Brain Metastatic Lesions

2017 ◽  
pp. 8-17
Author(s):  
A. A. Ermakova ◽  
O. Yu. Borodin ◽  
M. Yu. Sannikov ◽  
S. D. Koval ◽  
V. Yu. Usov
Keyword(s):  
Comparative Analysis ◽  
Roc Analysis ◽  
Magnetization Transfer ◽  
Metastatic Lesion ◽  
Transfer Effect ◽  
Wilcoxon Test ◽  
Post Contrast ◽  
Metastatic Lesions ◽  
The Brain ◽  
Non Parametric

Purpose: to investigate the diagnostic opportunities of contrast  magnetic resonance imaging with the effect of magnetization transfer effect in the diagnosis of focal metastatic lesions in the brain.Materials and methods.Images of contrast MRI of the brain of 16  patients (mean age 49 ± 18.5 years) were analysed. Diagnosis of  the direction is focal brain lesion. All MRI studies were carried out  using the Toshiba Titan Octave with magnetic field of 1.5 T. The  contrast agent is “Magnevist” at concentration of 0.2 ml/kg was  used. After contrasting process two T1-weighted studies were  performed: without T1-SE magnetization transfer with parameters of pulse: TR = 540 ms, TE = 12 ms, DFOV = 24 sm, MX = 320 × 224  and with magnetization transfer – T1-SE-MTC with parameters of pulse: ΔF = −210 Hz, FA(МТС) = 600°, TR = 700 ms, TE = 10 ms,  DFOV = 23.9 sm, MX = 320 x 224. For each detected metastatic  lesion, a contrast-to-brain ratio (CBR) was calculated. Comparative  analysis of CBR values was carried out using a non-parametric  Wilcoxon test at a significance level p < 0.05. To evaluate the  sensitivity and specificity of the techniques in the detection of  metastatic foci (T1-SE and T1-SE-MTC), ROC analysis was used. The sample is divided into groups: 1 group is foci ≤5 mm in size, 2  group is foci from 6 to 10 mm, and 3 group is foci >10 mm. Results.Comparative analysis of CBR using non-parametric Wilcoxon test showed that the values of the CBR on T1-weighted  images with magnetization transfer are significantly higher (p  <0.001) that on T1-weighted images without magnetization transfer. According to the results of the ROC analysis, sensitivity in detecting  metastases (n = 90) in the brain on T1-SE-MTC and T1-SE was  91.7% and 81.6%, specificity was 100% and 97.6%, respectively.  The accuracy of the T1-SE-MTC is 10% higher in comparison with  the technique without magnetization transfer. Significant differences (p < 0.01) between the size of the foci detected in post-contrast T1- weighted images with magnetization transfer and in post-contrast  T1-weighted images without magnetization transfer, in particular for  foci ≤5 mm in size, were found. Conclusions1. Comparative analysis of CBR showed significant (p < 0.001)  increase of contrast between metastatic lesion and white matter on  T1-SE-MTC in comparison with T1-SE.2. The sensitivity, specificity and accuracy of the magnetization transfer program (T1-SE-MTC) in detecting foci of  metastatic lesions in the brain is significantly higher (p < 0.01), relative to T1-SE.3. The T1-SE-MTC program allows detecting more foci in comparison with T1-SE, in particular foci of ≤5 mm (96% and 86%, respectively, with p < 0.05).

A fast B1-mapping method for the correction and normalization of magnetization transfer ratio maps at 3 T

NeuroImage ◽  
2010 ◽  
Vol 49 (4) ◽  
pp. 3015-3026 ◽  
Author(s):  
Steffen Volz ◽  
Ulrike Nöth ◽  
Anna Rotarska-Jagiela ◽  
Ralf Deichmann
Keyword(s):  
Magnetization Transfer ◽  
Mapping Method ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
B1 Mapping

Cervical cord magnetization transfer ratio and clinical changes over 18 months in patients with relapsing-remitting multiple sclerosis: a preliminary study

2006 ◽  
Vol 12 (5) ◽  
pp. 662-665 ◽  
Author(s):  
A Charil ◽  
D Caputo ◽  
R Cavarretta ◽  
M P Sormani ◽  
P Ferrante ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Relapse Rate ◽  
Magnetization Transfer ◽  
Small Sample ◽  
Cervical Cord ◽  
Magnetization Transfer Ratio ◽  
Short Term ◽  
Disease Evolution ◽  
Transfer Ratio ◽  
Relapsing Remitting

Background Magnetization transfer ratio (MTR) permits the quantitative estimation of cervical cord tissue damage in patients with multiple sclerosis (MS). Objective To determine whether a single time-point MTR scan of the cervical cord is associated with short-term disease evolution in patients with relapsing-remitting (RR) MS. Methods Using a 1.5-T magnetic resonance imaging (MRI) system with a tailored cervical cord phased array coil, fast short-tau inversion recovery (fast-STIR) and MTR scans were obtained from 14 untreated patients with RRMS at baseline. Cervical cord MTR histograms were derived. Over the 18- month follow-up period, relapse rate was measured and disability assessed by the Expanded Disability Status Scale (EDSS) score. Results Average cervical cord MTR was correlated with relapse rate ( r= -0.56, P = 0.037). A moderate correlation ( r values ranging from -0.33 to -0.36) between baseline cervical cord MTR metrics and EDSS changes over 18 months was also noted, albeit statistical significance was not reached ( P = 0.26 and 0.21, respectively) perhaps because of the relatively small sample size. Conclusions This study suggests that a ‘snapshot’ MT MRI assessment of the cervical cord may detect cervical cord tissue changes associated with short-term disease evolution in RRMS.

Sign in / Sign up

Export Citation Format

Share Document