scholarly journals Platelet Rich Fibrin (PRF) Application in Oral Surgery

Platelets ◽  
2020 ◽  
Author(s):  
Alper Saglanmak ◽  
Caglar Cinar ◽  
Alper Gultekin
Keyword(s):  
Alveolar Bone ◽  
Oral Surgery ◽  
Treatment Success ◽  
Patient Comfort ◽  
Sinus Augmentation ◽  
Platelet Rich Fibrin ◽  
Oroantral Fistula ◽  
Soft Tissue Regeneration ◽  
Oral Ulcers ◽  
Negative Beliefs

Platelet rich fibrin (PRF) is an autologous biological product which becomes popular day by day and available in a wide variety of fields in medicine. Platelet concentrates which are introduced at the early 90s have evolved over the years. The use such autologous materials have become trendy in recent years to encounter demanding expectations of patients, improve treatment success and maximize patient comfort. Despite its increasing use in dentistry and oral surgery, the most indications and effects are still being discussed. PRF is easily accepted by patients because of its low cost, easy to receive, low donor morbidity, low postoperative complication and infection rate. This biomaterial may be a solution for patients who have strong negative beliefs about the use of allografts and xenografts or who are afraid of complications during the grafting procedure. The objectives of these technologies are to use their synergistic effect to improve the hard and soft tissue regeneration. PRF in oral surgery are used for alveolar bone reconstruction, dental implant surgery, sinus augmentation, socket preservation, osteonecrosis, oroantral fistula closure, struggling with oral ulcers, preventing swelling and edema constitution. This chapter aims to review the clinical applications of platelets in oral surgery and the role of molecular components in tissue healing.

scholarly journals PLASMA RICO EM FIBRINA (PRF) COMO OPÇÃO DE RECOBRIMENTO APÓS ROTAÇÃO DE RETALHO PALATINO PARA TRATAMENTO DE FÍSTULA BUCOSSINUSAL

2020 ◽  
Author(s):  
Rafael Mérola Corrêa
Keyword(s):  
Clinical Case ◽  
Oral Surgery ◽  
Maxillary Sinusitis ◽  
Platelet Rich Fibrin ◽  
Mucosal Flap ◽  
Oroantral Fistula ◽  
Donor Area ◽  
Chronic Maxillary Sinusitis ◽  
Autogenous Grafts ◽  
Fibrin Membrane

ResumoO desenvolvimento de uma fístula bucossinusal, a partir de uma comunicação gerada entre a cavidade oral e o seio maxilar, pode ser favorecido por um não fechamento espontâneo ou por uma sinusite maxilar crônica já instalada. O tratamento da fístula bucossinusal depende de fatores que podem beneficiar ou dificultar o prognóstico dos casos, como a localização, causa e o tamanho do defeito gerado. Diferentes técnicas são descritas na literatura para o tratamento destes defeitos orosinusais, como retalhos locais deslizantes ou rotacionados, enxertos autógenos ou o uso da bola de gordura bucal.  O objetivo do presente trabalho é apresentar o caso clínico de uma fístula bucossinusal pós exodontia há aproximadamente 05 anos, não corrigida imediatamente, tratada através de retalho mucoso palatino rotacionado. Como coadjuvante para a cicatrização da área doadora foi utilizado membrana de fibrina rica em plaquetas. A técnica do retalho palatino mostrou-se uma opção favorável para o fechamento da fístula bucossinusal e o uso dos fatores de crescimento permitiu vascularização adequada na área doadora e no retalho rotacionado, o que favoreceu a hemostasia vascular e estimulou a recuperação dos tecidos moles adjacentes.Palavras-chave: Seio maxilar, fístula bucoantral, cirurgia bucal, fibrina rica em plaquetas.          AbstractThe development of a bucosinusal fistula from a communication generated between the oral and maxillary cavity may be favored by a spontaneous unblocked or an existing chronic maxillary sinusitis. The treatment of bucosinusal fistula depends on factors that may benefit or hinder the prognosis of cases, such as location, cause and size of the defect used. Different techniques are described in the literature for the treatment of these oral defects, such as sliding or rotating local flaps, autogenous grafts or the use of the buccal fat ball. The aim of the present study is to present the clinical case of a post-extraction bucosinusal fistula approximately 05 years ago, not immediately corrected, treated through a rotated palatal mucosal flap. As an adjunct to the healing of the donor area, a platelet-rich fibrin membrane was used. The palatal flap technique proved to be a favorable option for the closure of the bucosinusal fistula and the use of growth factors allowed adequate vascularization in the donor area and in the rotated flap, which favored vascular hemostasis and stimulated the recovery of adjacent soft tissues.Key-words: Maxillary sinus, oroantral fistula, oral surgery, platelet-rich fibrin  

scholarly journals Platelet Rich Fibrin - A Saviour for Replanted Teeth – A Review

2021 ◽  
Vol 10 (33) ◽  
pp. 2816-2823
Author(s):  
Sanjana Mall ◽  
Rajmohan Shetty ◽  
Amitha Hegde ◽  
Kavita Rai
Keyword(s):  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Treatment Success ◽  
Periodontal Regeneration ◽  
Root Surface ◽  
Periodontal Ligament Cells ◽  
Platelet Concentrates ◽  
Soft Tissue Healing ◽  
Platelet Rich Fibrin ◽  
Tissue Healing

The periodontal ligament is a unique specialised connective tissue between the cementum covering the tooth root and the alveolar bone. It is believed that periodontal ligament cells are responsible for not only osteogenesis and osteoclasia of the alveolar bone but also for fibrogenesis and fibroplasia of the ligament itself, as well as cementogenesis and the presence of cementoblasts on the root surface. Injury to the periodontal ligament (PDL) and its compromised healing (external inflammatory resorption and replacement resorption) has been cited as one of the major reasons for the failure of transplantation and replantation procedures. The necessity of having a healthy PDL so that the tooth can re-attach and be retained in the socket determines the prognosis of replanted teeth. Thus, the importance of maintaining the periodontal viability has led to an increased interest in the development of platelet concentrates, which have been considered as autologous biomaterials having the ability to potentiate healing, repair, and regenerate. PRF (platelet rich fibrin) is a living biomaterial derived from human blood containing fibrin, platelets, growth factors, leukocytes and stem cells entrapped in a fibrin-based scaffold / matrix, which has been documented to promote bone and soft tissue healing and regeneration. PRF technology has grabbed the attention of clinicians because it is readily available, is easy to prepare, can be produced immediately at the chairside, is easy to use, and widely applicable in dentistry, while being financially realistic for the patient and the clinician. Thus, the purpose of this review is to enumerate the biologic, chemical and physical properties of PRF and highlight the essential role it plays in periodontal regeneration and repair, which can be highly beneficial in improving the treatment success rate of transplantation and replantation procedures. KEY WORDS Platelet Rich Fibrin, Replantation, Transplantation, Periodontal Ligament, Periodontal Regeneration

PLASMA RICO EM FIBRINA (PRF) COMO OPÇÃO DE RECOBRIMENTO APÓS ROTAÇÃO DE RETALHO PALATINO PARA TRATAMENTO DE FÍSTULA BUCOSSINUSAL

2020 ◽  
Author(s):  
Rafael Mérola Corrêa
Keyword(s):  
Clinical Case ◽  
Oral Surgery ◽  
Maxillary Sinusitis ◽  
Platelet Rich Fibrin ◽  
Mucosal Flap ◽  
Oroantral Fistula ◽  
Donor Area ◽  
Chronic Maxillary Sinusitis ◽  
Autogenous Grafts ◽  
Fibrin Membrane

ResumoO desenvolvimento de uma fístula bucossinusal, a partir de uma comunicação gerada entre a cavidade oral e o seio maxilar, pode ser favorecido por um não fechamento espontâneo ou por uma sinusite maxilar crônica já instalada. O tratamento da fístula bucossinusal depende de fatores que podem beneficiar ou dificultar o prognóstico dos casos, como a localização, causa e o tamanho do defeito gerado. Diferentes técnicas são descritas na literatura para o tratamento destes defeitos orosinusais, como retalhos locais deslizantes ou rotacionados, enxertos autógenos ou o uso da bola de gordura bucal.  O objetivo do presente trabalho é apresentar o caso clínico de uma fístula bucossinusal pós exodontia há aproximadamente 05 anos, não corrigida imediatamente, tratada através de retalho mucoso palatino rotacionado. Como coadjuvante para a cicatrização da área doadora foi utilizado membrana de fibrina rica em plaquetas. A técnica do retalho palatino mostrou-se uma opção favorável para o fechamento da fístula bucossinusal e o uso dos fatores de crescimento permitiu vascularização adequada na área doadora e no retalho rotacionado, o que favoreceu a hemostasia vascular e estimulou a recuperação dos tecidos moles adjacentes.Palavras-chave: Seio maxilar, fístula bucoantral, cirurgia bucal, fibrina rica em plaquetas.          AbstractThe development of a bucosinusal fistula from a communication generated between the oral and maxillary cavity may be favored by a spontaneous unblocked or an existing chronic maxillary sinusitis. The treatment of bucosinusal fistula depends on factors that may benefit or hinder the prognosis of cases, such as location, cause and size of the defect used. Different techniques are described in the literature for the treatment of these oral defects, such as sliding or rotating local flaps, autogenous grafts or the use of the buccal fat ball. The aim of the present study is to present the clinical case of a post-extraction bucosinusal fistula approximately 05 years ago, not immediately corrected, treated through a rotated palatal mucosal flap. As an adjunct to the healing of the donor area, a platelet-rich fibrin membrane was used. The palatal flap technique proved to be a favorable option for the closure of the bucosinusal fistula and the use of growth factors allowed adequate vascularization in the donor area and in the rotated flap, which favored vascular hemostasis and stimulated the recovery of adjacent soft tissues.Key-words: Maxillary sinus, oroantral fistula, oral surgery, platelet-rich fibrin  

scholarly journals Role of Endoscopic Sinus Surgery and Dental Treatment in the Management of Odontogenic Sinusitis Due to Endodontic Disease and Oroantral Fistula

2021 ◽  
Vol 10 (12) ◽  
pp. 2712
Author(s):  
Anda Gâta ◽  
Corneliu Toader ◽  
Dan Valean ◽  
Veronica Elena Trombitaș ◽  
Silviu Albu
Keyword(s):  
Endoscopic Sinus Surgery ◽  
Dental Treatment ◽  
Treatment Success ◽  
Sinus Surgery ◽  
Rank Test ◽  
Oroantral Fistula ◽  
Surgical Closure ◽  
Communication Time ◽  
Odontogenic Sinusitis ◽  
Mean Time

Background: Odontogenic sinusitis (ODS) is frequently encountered in ENT practice; however, there are no guidelines regarding its management. This study aims to analyse the results of endoscopic sinus surgery versus dental treatment in ODS. Additionally, we aim to demonstrate the benefit of associating endoscopic sinus surgery (ESS) to surgical closure of chronic oroantral fistulas (OAF) by comparing mean time to healing in patients who opted or not for concurrent ESS. Methods: Records of patients with ODS were reviewed. Group one consisted of patients with ODS caused by periapical pathology undergoing either endoscopic sinus surgery (ESS) or dental treatment. Resolution of ODS was considered treatment success and was compared between the two treatment strategies. Group two included patients with ODS and associated chronic oroantral communication. Time to healing was compared between patients undergoing OAF closure alone versus patients receiving associated ESS, using the Log-Rank test to correlate Kaplan–Meier curves. Results: 25 patients from a total of 45 in group one underwent dental treatment alone, and 20 opted for exclusive ESS treatment. The failure rate was 40% for patients treated with ESS compared to 4% (one patient) for dental treatment. ODS resolved in all patients in the second group, but the mean time to healing was half (10 days) when ESS was complementary to OAF closure. Conclusion: The present study represents the first estimator of the role ESS plays in OAF treatment. Nonetheless, it provides proof of the importance of first addressing dental problems in odontogenic sinusitis.

scholarly journals Effectiveness of Silicon Platelet-Rich Fibrin and Autologous Bone on Bone Regeneration in Rabbit Calvarian Defects: A Radiological and Histological Study

2021 ◽  
Vol 11 (9) ◽  
pp. 4074
Author(s):  
Argimiro Hernández-Suarez ◽  
María Rizo-Gorrita ◽  
Dubraska Suárez-Vega ◽  
Gladys Velazco ◽  
Ivan Rodriguez Gelfenstein ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Oral Surgery ◽  
Histological Study ◽  
Study Groups ◽  
Control Group ◽  
Graft Material ◽  
Platelet Rich Fibrin ◽  
Computed Microtomography ◽  
Autologous Bone ◽  
Group 2

Repairing bone defects in oral surgery often requires the use of bone regeneration techniques. Silicon is an element that has been employed as regeneration material in several studies. In our study, silicon was combined with autologous bone and platelet-rich fibrin (PRF) membranes to analyse the behaviour of this element in bone regeneration. Four circumferential defects were created in the cranial vault of five New Zealand rabbits. The following elements were applied to the regeneration of the defects: (P): PRF; (S): silicon and (B): autologous bone, with the following distribution of study groups: Group 1 (PSB); Group 2 (PS); Group 3 (SB) and Group 4 (CONTROL): unregenerate group. The animals were sacrificed after 3 weeks. Computed microtomography studies (μ-CT) were carried out, as well as histomorphometric ones. The ANOVA statistical test was used with a Bonferroni post-hoc test to compare the results (p ≤ 0.05). Radiologically, groups PSB and SB were better as far as quantity and percentage of healthy bone observed, but not significantly compared to the control group. The PS group was significantly worse. The histological test revealed that the PSB group was the one to present the largest area, percentage and perimeter of mineralised bone. On evaluating the forming bone (osteoid), no difference was observed across the groups with the exception of the bone perimeter, where the SB group was significantly better. The bone height variable showed no significant differences. In conclusion we can state that the combination of PRF, autologous bone and silicon provides good results at 3 weeks whilst the PS group shows the worst results. This highlights the importance of autologous bone forming part of the graft material in order for the bone to mineralise.

scholarly journals Versatility of the cone beam computed tomography in oral surgery: an overview

2011 ◽  
Vol 1 (2) ◽  
pp. 31
Author(s):  
Kishan G. Panicker ◽  
Anuroopa Pudukulangara Nair ◽  
Bipin Chandra Reddy
Keyword(s):  
Computed Tomography ◽  
Alveolar Bone ◽  
Oral Surgery ◽  
Cone Beam Ct ◽  
Cone Beam ◽  
Facial Skeleton ◽  
Posterior Teeth ◽  
True Nature ◽  
Root Apices ◽  
Relationship Of

Cone beam CT (CBCT) produces threedimensional information on the facial skeleton, teeth and their surrounding tissues; and is increasingly being used in many of the dental specialties. This is usually achieved with a substantially lower effective dose compared with conventional medical computed tomography (CT). Periapical pathologies, root fractures, root canal anatomy and the true nature of the alveolar bone topography around teeth may be assessed. CBCT scans are desirable to assess posterior teeth prior to periapical surgery, as the thickness of the cortical and cancellous bone can be accurately determined as can the inclination of roots in relation to the surrounding jaw. The relationship of anatomical structures such as the maxillary sinus and inferior dental nerve to the root apices may also be clearly visualized. Measurements on CBCT are more accurate when compared with OPG. Therefore, CBCT permits the clinician to have all necessary information when planning dental implants. The purpose of this article is to provide an overview of the unique image display capabilities of maxillofacial CBCT systems and to illustrate specific applications in clinical practice.

scholarly journals Clinical and Histologic Evaluation of Using Block Xenograft Combined With Leukocyte-Platelet Rich Fibrin (L-PRF) Versus Intraoral Autogenous Bone Block Graft With L-PRF in Treating Localized Ridge Defects: A Randomized Clinical Trial

Perio J ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 11-21
Author(s):  
Ahmed Y. Gamal ◽  
Shahinaz G. Elashiry ◽  
Fatma H. Eldemerdash ◽  
Omar M. Elnashar
Keyword(s):  
Alveolar Bone ◽  
Autogenous Bone ◽  
Bone Block ◽  
Bone Augmentation ◽  
Class Iii ◽  
Platelet Rich Fibrin ◽  
Oral Implants ◽  
Histologic Evaluation

Background: Augmentation of vertical bone defects remains the corner stone in periodontal tissue engineering. The amount and quality of alveolar bone available in all dimensions affects the success of dental implants for restoration of edentulous areas. Adequate and healthy bone supports the degree of osseointegration which in turn affects the long-term success of oral implants. The primary aim of the study was to histologically evaluate autogenous block grafts versus synthetic block grafts for the treatment of atrophic vertical and horizontal bony defects (Siebert Class III) in the anterior esthetic zone of the mouth. The secondary aim was to clinically and radiographically evaluate the outcomes of the procedure. Methods: This was a randomized controlled clinical study with a statistically determined sample size of 10 patients per group and a total of 20 patients in both groups. Patients with vertical and horizontal bone loss were enrolled from the Department of Oral Medicine, Periodontology, and Oral Diagnosis of Ain Shams University and Misr International University. Bone augmentation procedures were performed using two techniques: autogenous bone block graft and xenograft bone block graft both with leukocyte-platelet rich fibrin (L-PRF). Results: Both autogenous and xenograft blocks in conjunction with L-PRF had a significant effect on vertical bone augmentation in cases of atrophic ridges in the esthetic region. Conclusion: Both autogenous and xenograft bone blocks in conjunction with L-PRF have a significant effect on vertical bone augmentation in cases of atrophic ridges in the esthetic region.

scholarly journals Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Qi Li ◽  
Shuang Pan ◽  
Smit J. Dangaria ◽  
Gokul Gopinathan ◽  
Antonia Kolokythas ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Principal Component ◽  
Nodule Formation ◽  
Bone Augmentation ◽  
Pilot Studies ◽  
Platelet Rich Fibrin ◽  
Lineage Differentiation ◽  
Osteogenic Lineage

In the present study we have determined the suitability of platelet-rich fibrin (PRF) as a complex scaffold for periodontal tissue regeneration. Replacing PRF with its major component fibrin increased mineralization in alveolar bone progenitors when compared to periodontal progenitors, suggesting that fibrin played a substantial role in PRF-induced osteogenic lineage differentiation. Moreover, there was a 3.6-fold increase in the early osteoblast transcription factor RUNX2 and a 3.1-fold reduction of the mineralization inhibitor MGP as a result of PRF application in alveolar bone progenitors, a trend not observed in periodontal progenitors. Subcutaneous implantation studies revealed that PRF readily integrated with surrounding tissues and was partially replaced with collagen fibers 2 weeks after implantation. Finally, clinical pilot studies in human patients documented an approximately 5 mm elevation of alveolar bone height in tandem with oral mucosal wound healing. Together, these studies suggest that PRF enhances osteogenic lineage differentiation of alveolar bone progenitors more than of periodontal progenitors by augmenting osteoblast differentiation, RUNX2 expression, and mineralized nodule formation via its principal component fibrin. They also document that PRF functions as a complex regenerative scaffold promoting both tissue-specific alveolar bone augmentation and surrounding periodontal soft tissue regeneration via progenitor-specific mechanisms.

scholarly journals Concentrated Growth Factors vs. Leukocyte-and-Platelet-Rich Fibrin for Enhancing Postextraction Socket Healing. A Longitudinal Comparative Study

2020 ◽  
Vol 10 (22) ◽  
pp. 8256
Author(s):  
Marco Mozzati ◽  
Giorgia Gallesio ◽  
Margherita Tumedei ◽  
Massimo Del Fabbro
Keyword(s):  
Growth Factors ◽  
Oral Surgery ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Significant Difference ◽  
Postoperative Symptoms ◽  
Concentrated Growth Factors ◽  
Socket Healing ◽  
And Control ◽  
Tooth Extractions

Platelet concentrates (PCs) have been used for over 20 years in dentistry, as an adjunct to oral surgery procedures, to improve hard and soft tissue healing and control postoperative symptoms. Among various PCs, Leukocyte and Platelet-Rich Fibrin (L-PRF) has become very popular due to its excellent cost-effectiveness ratio, and to the simple preparation protocol, but comparative clinical studies with other PCs are lacking. The aim of this split-mouth cohort study was to evaluate the effect of Concentrated Growth Factors (CGF), a recently introduced PC, as compared to L-PRF for enhancing post-extraction socket healing. Methods: Patients in need of bilateral tooth extractions were included. Each side was treated with either CGF or L-PRF. Pain, socket closure and healing index were the main outcomes. Results: Forty-five patients (24 women), aged 60.52 ± 11.75 years (range 37–87 years) were treated. No significant difference in outcomes was found, except for Pain at day 1 (p < 0.001) and socket closure in the vestibulo-palatal/lingual dimension at day 7 post-extraction (p = 0.04), both in favor of CGF. Conclusions: based on the present results, CGF proved to be as effective and safe as L-PRF, representing a valid alternative option for improving alveolar socket healing and reducing postoperative discomfort.

Sign in / Sign up

Export Citation Format

Share Document