scholarly journals Neuroprotective Effects of Curcumin and Vitamin D3 on Scopolamine-Induced Learning-Impaired Rat Model of Alzheimer’s Disease

2020 ◽  
Author(s):  
Saima Khan ◽  
Kaneez Fatima Shad
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin D3 ◽  
Rat Model ◽  
Neuroprotective Effects ◽  
Model Of Alzheimer’S Disease

scholarly journals Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Chenxia Sheng ◽  
Panpan Xu ◽  
Kexin Zhou ◽  
Dan Deng ◽  
Chunhu Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Learning And Memory ◽  
Rat Model ◽  
Intragastric Administration ◽  
Neuroprotective Effects ◽  
Treatment And Prevention ◽  
Model Of Alzheimer’S Disease ◽  
Epimedium Sagittatum

Icariin (ICA), a prenylated flavanol glycoside present in abundant quantities in Epimedium sagittatum, has shown promise in the treatment and prevention of Alzheimer’s disease. Damage to synaptic plasticity induced by amyloid-beta-mediated neurotoxicity is considered a main pathological mechanism driving the learning and memory deficits present in patients with Alzheimer’s disease. This study investigated the neuroprotective effects of icariin in an Aβ1–42-induced rat model of Alzheimer’s disease. Our results showed that Aβ1–42 injection induced loss of learning and memory behaviour in the Morris water maze, which could be reversed with intragastric administration of ICA. Furthermore, ICA reversed decreases in PSD-95, BDNF, pTrkB, pAkt, and pCREB expressions and prevented deterioration of synaptic interface structure. These findings indicate that ICA may improve synaptic plasticity through the BDNF/TrkB/Akt pathway and provide further evidence for its clinical application to improve learning and memory in patients with Alzheimer’s disease.

scholarly journals Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer’s disease

Brain ◽  
2017 ◽  
Vol 140 (11) ◽  
pp. 3023-3038 ◽  
Author(s):  
Jacki M Rorabaugh ◽  
Termpanit Chalermpalanupap ◽  
Christian A Botz-Zapp ◽  
Vanessa M Fu ◽  
Natalie A Lembeck ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Locus Coeruleus ◽  
Reversal Learning ◽  
Rat Model ◽  
Model Of Alzheimer’S Disease
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