The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells

2021 ◽  
Author(s):  
Xinrong Pei ◽  
Fangyan Hu ◽  
Feiya Luo ◽  
Xianglu Huang ◽  
Xiaoling Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pc12 Cells ◽  
Experimental Model ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Neuroprotective Effects ◽  
Model Of Alzheimer’S Disease

Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease

Peptides ◽  
2006 ◽  
Vol 27 (12) ◽  
pp. 3363-3369 ◽  
Author(s):  
Lígia M. Iores-Marçal ◽  
Tânia A. Viel ◽  
Hudson Sousa Buck ◽  
Viviane A. Nunes ◽  
Andrezza J. Gozzo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Experimental Model ◽  
Model Of Alzheimer’S Disease

scholarly journals Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Dongdong Zhang ◽  
Zhe Wang ◽  
Chenxia Sheng ◽  
Weijun Peng ◽  
Shan Hui ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pc12 Cells ◽  
Amyloid Beta ◽  
Chinese Herb ◽  
Protective Effects ◽  
Amyloid Beta Protein ◽  
Neuroprotective Effects ◽  
Pi3k Inhibitor Ly294002 ◽  
Induced Apoptosis

Icariin is a prenylated flavonol glycoside derived from the Chinese herbEpimedium sagittatumthat exerts a variety of pharmacological activities and shows promise in the treatment and prevention of Alzheimer’s disease. In this study, we investigated the neuroprotective effects of icariin against amyloid beta protein fragment 25–35 (Aβ25–35) induced neurotoxicity in cultured rat pheochromocytoma PC12 cells and explored potential underlying mechanisms. Our results showed that icariin dose-dependently increased cell viability and decreasedAβ25–35-induced apoptosis, as assessed by MTT assay and Annexin V/propidium iodide staining, respectively. Results of western blot analysis revealed that the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed icariin-induced Akt phosphorylation, suggesting that the protective effects of icariin are associated with activation of the PI3K/Akt signaling pathway. LY294002 also blocked the icariin-induced downregulation of proapoptotic factors Bax and caspase-3 and upregulation of antiapoptotic factor Bcl-2 inAβ25–35-treated PC12 cells. These findings provide further evidence for the clinical efficacy of icariin in the treatment of Alzheimer’s disease.

scholarly journals Neuroprotective Effects of Limonene (+) against Aβ42-Induced Neurotoxicity in a Drosophila Model of Alzheimer’s Disease

2020 ◽  
Vol 43 (3) ◽  
pp. 409-417 ◽  
Author(s):  
Myeongcheol Shin ◽  
Quan Feng Liu ◽  
Byoungyun Choi ◽  
Changmin Shin ◽  
Banseok Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuroprotective Effects ◽  
Model Of Alzheimer’S Disease

P284 Experimental model of Alzheimer's disease

1996 ◽  
Vol 99 (4) ◽  
pp. 336
Author(s):  
A. Milovanovic ◽  
J. Milovanovic ◽  
E. Radulovic ◽  
D. Micic ◽  
B.B. Mrsulja
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Experimental Model ◽  
Model Of Alzheimer’S Disease

P2-333: Vascular inflammation and leukocyte trafficking in an experimental model of Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S416-S416
Author(s):  
Elena Zenaro ◽  
Simona Budui ◽  
Enrica Pietronigro ◽  
Vittorina Della Bianca ◽  
Barbara Rossi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Experimental Model ◽  
Vascular Inflammation ◽  
Leukocyte Trafficking ◽  
Model Of Alzheimer’S Disease

scholarly journals A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease

2013 ◽  
Vol 38 (1) ◽  
pp. 111-120 ◽  
Author(s):  
Lynne Shinto ◽  
Joseph Quinn ◽  
Thomas Montine ◽  
Hiroko H. Dodge ◽  
William Woodward ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Lipoic Acid ◽  
Pilot Trial ◽  
Alpha Lipoic Acid ◽  
Omega 3 Fatty Acids ◽  
Omega 3
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