scholarly journals Interplay between Human Intestinal Microbiota and Gut-to-Brain Axis: Relationship with Autism Spectrum Disorders

2020 ◽  
Author(s):  
Francisco Javier Díaz-García ◽  
Saúl Flores-Medina ◽  
Diana Mercedes Soriano-Becerril
Keyword(s):  
Autism Spectrum Disorders ◽  
Intestinal Microbiota ◽  
Autism Spectrum ◽  
Human Intestinal Microbiota ◽  
Spectrum Disorders

scholarly journals Disturbances of intestinal microbiota in autism spectrum disorders: new horizons in search for pathogenetic approaches to therapy. Рart 3. Рotential strategies of influence on gut-brain axis for correction of symptoms of autism spectrum disorders

2021 ◽  
Vol 98 (3) ◽  
pp. 331-338
Author(s):  
A. S. Blagonravova ◽  
T. V. Zhilyaeva ◽  
D. V. Kvashnina
Keyword(s):  
Autism Spectrum Disorders ◽  
Intestinal Microbiota ◽  
Autism Spectrum ◽  
Published Data ◽  
New Horizons ◽  
Intestinal Dysbiosis ◽  
Spectrum Disorders ◽  
Based Medicine ◽  
Further Development

The third part of the literature review on the role of intestinal microbiota disturbances in the pathogenesis of autism spectrum disorders (ASD) is devoted to the analysis of published literature on possible interventional approaches for intestinal microbiota in ASD and the evaluation of the effectiveness of various types of interventions that have been studied in experiment and in clinical practice. Presented are available data on the possibility of correcting the intestinal microbiota in ASD with diet, taking pre- and probiotics, antibiotic therapy, as well as the effectiveness of transplantation of intestinal microbiota. An analysis of published data suggests that further development of approaches for correcting intestinal dysbiosis in ASD may provide safe and probably effective strategy for behavioral symptoms, but this requires further randomized controlled trials to confirm efficacy and safety from the perspective of evidence-based medicine, since available to date studies are small and scattered, and therefore they can only be considered preliminary.

Gut Microbiota and Gender in Autism Spectrum Disorders

2020 ◽  
Vol 16 ◽  
Author(s):  
Rafail I. Kushak ◽  
Harland S. Winter
Keyword(s):  
Gender Differences ◽  
Autism Spectrum Disorders ◽  
Gut Microbiota ◽  
Sex Hormones ◽  
Intestinal Microbiota ◽  
Autism Spectrum ◽  
Intestinal Microbiome ◽  
Gender Dimorphism ◽  
Spectrum Disorders ◽  
The Impact

: Gender dimorphism in autism spectrum disorders (ASD) is well known; however, the reasons for gender differences in autism are poorly understood. There are several hypotheses that might explain male prevalence in ASD including increased levels of androgens, “extreme male brain,” and a combination of elevated levels of prenatal testosterone in conjunction with prenatal stress. In this review, differences in the gut microbiome and metabolome in humans and animals are described to explain gender differences in individuals with ASD, effects on behavior and social interactions and the impact of antibiotics, probiotics and fecal transplants. The bidirectional relationship between sex hormones and intestinal microbiota could also be relevant. Such interactions have been described in autoimmune diseases, but thus far are not implicated in ASD. We hypothesize that similar cross-talk exists in ASD between gut microbiota and sex hormones. Since intestinal microbiota may affect behavior, it is possible that prevalence of ASD in boys may be associated with more significant changes in the intestinal microbiome than in affected girls.

scholarly journals Autism spectrum disorders and intestinal microbiota

Gut Microbes ◽  
2015 ◽  
Vol 6 (3) ◽  
pp. 207-213 ◽  
Author(s):  
Maria De Angelis ◽  
Ruggiero Francavilla ◽  
Maria Piccolo ◽  
Andrea De Giacomo ◽  
Marco Gobbetti
Keyword(s):  
Autism Spectrum Disorders ◽  
Intestinal Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Autism and Our Intestinal Microbiota

2015 ◽  
Vol 25 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Bhaskara Lakshmi Reddy ◽  
Milton H. Saier
Keyword(s):  
Autism Spectrum Disorders ◽  
Blood Brain Barrier ◽  
Intestinal Microbiota ◽  
Neurological Disorders ◽  
Mental States ◽  
Autism Spectrum ◽  
Brain Barrier ◽  
Blood Brain ◽  
Microbial Products ◽  
Spectrum Disorders

Microbial products, released into the bloodstreams of mammals including humans, cross the blood-brain barrier and influence neurodevelopment. They can either promote or alleviate neurological disorders including autism spectrum disorders (ASD). This editorial describes how our microbiota influence our feelings, attitudes and mental states with particular reference to ASD.

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