scholarly journals Autism and Our Intestinal Microbiota

2015 ◽  
Vol 25 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Bhaskara Lakshmi Reddy ◽  
Milton H. Saier
Keyword(s):  
Autism Spectrum Disorders ◽  
Blood Brain Barrier ◽  
Intestinal Microbiota ◽  
Neurological Disorders ◽  
Mental States ◽  
Autism Spectrum ◽  
Brain Barrier ◽  
Blood Brain ◽  
Microbial Products ◽  
Spectrum Disorders

Microbial products, released into the bloodstreams of mammals including humans, cross the blood-brain barrier and influence neurodevelopment. They can either promote or alleviate neurological disorders including autism spectrum disorders (ASD). This editorial describes how our microbiota influence our feelings, attitudes and mental states with particular reference to ASD.

scholarly journals Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Maria Fiorentino ◽  
Anna Sapone ◽  
Stefania Senger ◽  
Stephanie S. Camhi ◽  
Sarah M. Kadzielski ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Blood Brain Barrier ◽  
Autism Spectrum ◽  
Brain Barrier ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Blood Brain ◽  
Spectrum Disorders

scholarly journals Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability

2021 ◽  
Author(s):  
Chiara Borsari ◽  
Erhan Keles ◽  
Andrea Treyer ◽  
Martina De Pascale ◽  
Paul Hebeisen ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Neurological Disorders ◽  
Second Generation ◽  
Mtor Inhibitor ◽  
Kinase Inhibitor ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability

Here we present the first pyrimido-pyrrolo-oxazine-based mTOR kinase inhibitor (11) predicted to penetrate the blood brain barrier (BBB). Thus, 11 has a potential in treatments of neurological disorders.

scholarly journals Pharmacological targeting of the PDGF-CC signaling pathway for blood–brain barrier restoration in neurological disorders

2016 ◽  
Vol 167 ◽  
pp. 108-119 ◽  
Author(s):  
Sebastian A. Lewandowski ◽  
Linda Fredriksson ◽  
Daniel A. Lawrence ◽  
Ulf Eriksson
Keyword(s):  
Signaling Pathway ◽  
Blood Brain Barrier ◽  
Neurological Disorders ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

2019 ◽  
Vol 20 (7) ◽  
pp. 1632 ◽  
Author(s):  
Michelle Erickson ◽  
William Banks
Keyword(s):  
Central Nervous System ◽  
Immune System ◽  
Blood Brain Barrier ◽  
Neurological Disorders ◽  
Brain Barrier ◽  
Immune Functions ◽  
Blood Brain ◽  
The Brain ◽  
Brain Barriers

Age is associated with altered immune functions that may affect the brain. Brain barriers, including the blood–brain barrier (BBB) and blood–CSF barrier (BCSFB), are important interfaces for neuroimmune communication, and are affected by aging. In this review, we explore novel mechanisms by which the aging immune system alters central nervous system functions and neuroimmune responses, with a focus on brain barriers. Specific emphasis will be on recent works that have identified novel mechanisms by which BBB/BCSFB functions change with age, interactions of the BBB with age-associated immune factors, and contributions of the BBB to age-associated neurological disorders. Understanding how age alters BBB functions and responses to pathological insults could provide important insight on the role of the BBB in the progression of cognitive decline and neurodegenerative disease.

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