scholarly journals An Evidence-Based Review of Efficacy and Safety of Dietary, Natural Supplements and Sunlight in Vitamin D Deficiency

2020 ◽  
Author(s):  
Jenson Mak
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Evidence Based ◽  
Efficacy And Safety

An evidence based approach to vitamin D deficiency in the child and adolescent refugee population of Western Australia (WA)

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S89-S90 ◽  
Author(s):  
A. Siafarikas ◽  
E. Pascoe ◽  
S. Banfield ◽  
S. Cherian ◽  
J. Geddes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Western Australia ◽  
Child And Adolescent ◽  
Evidence Based ◽  
Refugee Population

Promoting healthy nutrition

2019 ◽  
Author(s):  
Charlotte M. Wright
Keyword(s):  
Vitamin D ◽  
Preschool Children ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Complementary Feeding ◽  
Healthy Diet ◽  
Evidence Based ◽  
Healthy Nutrition

Key nutritional issues affecting preschool children discussed in this chapter are breastfeeding, complementary feeding, and promoting a healthy diet. The evidence on iron deficiency and vitamin D deficiency is reviewed. Recommendations are made for commissioning of services to support breastfeeding, and evidence-based advice given for practitioners.

scholarly journals Comprehensive assessment of the pharmacokinetic properties of a single bolus dose of colecalciferol in terms of efficacy and safety

2019 ◽  
Vol 22 (1) ◽  
pp. 4-9
Author(s):  
Liudmila A. Suplotova ◽  
Valeria A. Avdeeva ◽  
Ekaterina A. Pigarova ◽  
Liudmila Y. Rozhinskaya
Keyword(s):  
Vitamin D ◽  
Clinical Practice ◽  
Adverse Events ◽  
Vitamin D Deficiency ◽  
Calcium Metabolism ◽  
Bolus Dose ◽  
Efficacy And Safety ◽  
Single Bolus ◽  
Pharmacokinetic Properties ◽  
Single Bolus Dose

Background: The lack of a unified approach to the treatment of deficiency and vitamin D deficiency stimulated a detailed study of the dynamics of indicators of phosphorus-calcium metabolism, parathyroid hormone, 25(OH)D (calcidiol). Aim: To evaluate the pharmacokinetic properties of colecalciferol at a dosage of 150 000 IU, from the standpoint of its efficacy and safety in clinical practice. Materials and methods: Observational, single-center, prospective, selective, uncontrolled study of a comprehensive assessment of the pharmacokinetic properties of a single saturating dose of 150 000 IU of colecalciferol. To assess the pharmacokinetic properties of colecalciferol at a dosage of 150 000 IU, we set efficacy and safety criteria. The criterion for the effectiveness of treatment was to achieve an adequate level of vitamin D (more than 30 ng / ml at the initial insufficient level and more than 20 ng / ml for patients with vitamin D deficiency). The safety criteria for the correction of vitamin D deficiency or deficiency were the absence of patient complaints, adverse events and / or serious adverse events, as well as the preservation of the main laboratory parameters of phosphorus-calcium metabolism within the reference values. Results: When studying the efficacy of a dose of 150 000 IU in patients with vitamin D deficiency and insufficiency, it was found that the level of calcidiol was significantly higher in the group after treatment with colecalciferol compared with the group before treatment (p 0.05). The peak of the maximum value for patients with deficiency was established on the 14 day from the moment of administration of colecalciferol and was 37.1 6.28 ng / ml, and for patients with initial vitamin D deficiency 40.1 3.71 ng / ml. In the study of the safety of colecalciferol in a bolus dose of 150 000 IU, there were no statistically significant differences in the laboratory parameters of calcium-phosphorus metabolism, both in the group before treatment and after correction of deficiency and vitamin D insufficiency in both groups. Conclusion: Colecalciferol in the form of a single bolus dose of 150 000 IU demonstrated its efficacy and safety in real clinical practice.

scholarly journals Myth Busters: Dietary Supplements and COVID-19

2020 ◽  
Vol 54 (8) ◽  
pp. 820-826 ◽  
Author(s):  
Kathleen K. Adams ◽  
William L. Baker ◽  
Diana M. Sobieraj
Keyword(s):  
Social Media ◽  
Vitamin D ◽  
Vitamin C ◽  
Dietary Supplements ◽  
Evidence Based ◽  
Efficacy And Safety ◽  
Treatment And Prevention ◽  
Social Media Platforms ◽  
Evidence Based Guidelines

News and social media platforms have implicated dietary supplements in the treatment and prevention of coronavirus disease 2019 (COVID-19). During this pandemic when information quickly evolves in the presence of contradicting messages and misinformation, the role of the pharmacist is essential. Here, we review theoretical mechanisms and evidence related to efficacy and safety of select supplements in the setting of COVID-19, including vitamin C, vitamin D, zinc, elderberry, and silver. Evidence evaluating these supplements in COVID-19 patients is lacking, and providers and patients should not rely on dietary supplements to prevent or treat COVID-19. Rather, reference to evidence-based guidelines should guide treatment decisions.

The Association between Vitamin D Deficiency and Chronic Tonsillitis in Children: an Evidence Based Case Reports

2021 ◽  
Vol 2 (3) ◽  
pp. 167-174
Author(s):  
Ardian Sandhi Pramesti ◽  
Gabriella Nurahmani Putri ◽  
Steffi Sonia
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pediatric Patients ◽  
Case Reports ◽  
Chronic Tonsillitis ◽  
Evidence Based ◽  
Recurrent Tonsillitis ◽  
Exclusion Criteria ◽  
Innate And Adaptive Immunity ◽  
Increased Risk

Background: vitamin D has an important influence on the host’s immune system by modulating both innate and adaptive immunity and regulating the inflammatory cascade. Vitamin D deficiency may be related with reduced immunomodulation, specifically in preventing the occurrence of chronic tonsillitis. Objective: to identify the association between vitamin D deficiency with chronic tonsillitis in pediatric patients. Methods: the search was conducted with advanced searching on PubMed® and Cochrane® according to the clinical question. The screening of title and abstract using inclusion and exclusion criteria, double filter, and reading full text led to six useful articles. The selected studies were critically appraised for validity, importance, and applicability.  Results: three original articles were eligible for this evidence-based case report. All studies were considered to have good validity. All three studies reported an increased risk of chronic tonsillitis with the vitamin D deficiency and/or insufficiency. Conclusion: Vitamin D deficiency may be associated with the increased risk of chronic or recurrent tonsillitis in children.

scholarly journals Efficacy and safety of vitamin D3 B.O.N intramuscular injection in Korean adults with vitamin D deficiency

2016 ◽  
Vol 2 (4) ◽  
pp. 228-237 ◽  
Author(s):  
Han Seok Choi ◽  
Yoon-Sok Chung ◽  
Yong Jun Choi ◽  
Da Hea Seo ◽  
Sung-Kil Lim
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Intramuscular Injection ◽  
Efficacy And Safety ◽  
Korean Adults

The Association between Vitamin D Deficiency and Chronic Tonsillitis in Children: an Evidence Based Case Report

2021 ◽  
Vol 2 (1) ◽  
pp. 140-145
Author(s):  
Ardian Sandhi Pramesti ◽  
Gabriella Nurahmani Putri ◽  
Steffi Sonia
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Vitamin D Deficiency ◽  
Chronic Tonsillitis ◽  
Evidence Based ◽  
Clinical Question ◽  
Recurrent Tonsillitis ◽  
Exclusion Criteria ◽  
Innate And Adaptive Immunity ◽  
Increased Risk

A B S T R A C TBackground: vitamin D has an important influence on the host’s immune system bymodulating both innate and adaptive immunity and regulating the inflammatorycascade. Vitamin D deficiency may be related with reduced immunomodulation,specifically in preventing the occurrence of chronic tonsillitis. Objective: to identify theassociation between vitamin D deficiency with chronic tonsillitis in pediatric patients.Methods: the search was conducted with advanced searching on PubMed® andCochrane® according to the clinical question. The screening of title and abstract usinginclusion and exclusion criteria, double filter, and reading full text led to six usefularticles. The selected studies were critically appraised for validity, importance, andapplicability. Results: three original articles were eligible for this evidence-based casereport. All studies were considered to have good validity. All three studies reported anincreased risk of chronic tonsillitis with the vitamin D deficiency and/or insufficiency.Conclusion: Vitamin D deficiency may be associated with the increased risk of chronicor recurrent tonsillitis in children.

scholarly journals COVID-19 and vitamin D supplementation: Is there any evidence based to reduce the risk?

2021 ◽  
Vol 4 (10) ◽  
pp. S19-S24
Author(s):  
Amina Chentouf
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Respiratory Infections ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Published Data ◽  
Evidence Based ◽  
Dihydroxyvitamin D ◽  
Current Context

Several studies and meta-analysis suggest that vitamin D deficiency constitutes a risk factor for acute respiratory infections while supplementation may reduce this risk. Given the current context of the COVID-19 pandemic, the role of vitamin D supplementation in the prevention and improvement of the prognosis of affected patients has been suggested by some studies and refuted by others. Through this article, we report the mechanisms of action and properties of vitamin D, and we discuss the different hypotheses of the involvement of vitamin D in respiratory infections, especially COVID-19 in the light of the most recent published data. Keywords: COVID-19, SARS-CoV-2, Vitamin D deficiency, Vitamin D supplementation, 1.25-dihydroxyvitamin D.

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