scholarly journals An Update on the Screening, Diagnosis, Management, and Treatment of Vitamin D Deficiency in Individuals with Cystic Fibrosis: Evidence-Based Recommendations from the Cystic Fibrosis Foundation

2012 ◽  
Vol 97 (4) ◽  
pp. 1082-1093 ◽  
Author(s):  
V. Tangpricha ◽  
A. Kelly ◽  
A. Stephenson ◽  
K. Maguiness ◽  
J. Enders ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Evidence Based ◽  
Cystic Fibrosis Foundation

An evidence based approach to vitamin D deficiency in the child and adolescent refugee population of Western Australia (WA)

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S89-S90 ◽  
Author(s):  
A. Siafarikas ◽  
E. Pascoe ◽  
S. Banfield ◽  
S. Cherian ◽  
J. Geddes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Western Australia ◽  
Child And Adolescent ◽  
Evidence Based ◽  
Refugee Population

P06 A study to assess the effectiveness of vitamin d supplementation in paediatric cystic fibrosis patients

2018 ◽  
Vol 103 (2) ◽  
pp. e1.9-e1
Author(s):  
Christiansen Nanna ◽  
Ashraf Saleha
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Dose Range ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
List Type ◽  
Current Guideline ◽  
Paediatric Patients ◽  
Significant Difference

AimsPatients with cystic fibrosis (CF) require supplementation of fat-soluble vitamins due to the effects of the disease on the pancreas and the resulting inability of absorb fat effectively.1The study aimed to assess the effectiveness of current of vitamin D supplementation to achieve adequate serum Vitamin D (25OHD) levels in paediatric CF patients.2 Secondly, this study assessed the effectiveness of ‘Stoss’ therapy (a high dose vitamin D therapy administered every three months) as an alternative to daily vitamin D supplementation for patients with known poor compliance.3MethodsVitamin D doses and serum 25OHD levels between January and December 2016 were reviewed for paediatric CF patients at a UK centre. Data was collected for 138 paediatric patients. The ‘clinical record summary’ system was used to extract the data which included age, hospital number, weight in 2015 and 2016, 25OHD levels from 2015 and 2016, vitamin D dose before each level and pancreatic status.Data was entered onto Statistical Package for the Social Sciences (SPSS) system for analysis. A paired T-test was conducted to ascertain if there was a significant difference in weekly/kg doses between patients that were sufficient (25OHD>50 nmol/L) and insufficient (25OHD<50 nmol/L).ResultsData was collected for a total of 138 patients. The data from only 70 patients was analysed when investigating the first objective, as all other patients did not have 25OHD levels available for both 2015 and 2016. A further five patients wereexcluded and analysed seperately due to receiving Stoss therapy. The weekly Vitamin D dose range was very wide for both years with 43% (n=40) of patients requiring additional vitamin D in addition to Aquadeks (CF multivitamin preparation). There was no significant difference in Vitamin D doses between patients with sufficient and insufficient 25OHD levels. This was thecase for both 2015 (p=0.432) and 2016 (p=0.192). The daily supplementation doses were successful at maintaining vitamin D sufficiency for 83% of patients in 2015 and 93% in 2016.Out of the 5 patients who received ‘Stoss’ therapy, 3 had an increase in 25OHD levels. However, only one of the patients had a significant increase leading to sufficient 25OHD levels. In 2 cases there was actually a 60%–68% decrease in 25OHD levels, which lead to these patients developing vitamin D deficiency.ConclusionThis study was useful in determining the effectiveness of current Vitamin D dosing. The results suggest that patients having insufficient 25OHD levels may not be due to an inadequacy of doses provided in the current guideline, as there was no significant difference in dose between patients with sufficient and insufficient 25OHD levels. Given the patient group, the difference could be attributable to a lack of compliance to daily therapies in the patients with insufficient 25OHD levels or even differences in individual responses to therapy.In this sample, ‘Stoss’ therapy is not effective in maintaining sufficient 25OHD levels. Although the data for this part of the study was very limited, it identifies a need to investigate the effectiveness of ‘Stoss’ therapy further.ReferencesFerguson JH, Chang AB. Vitamin D supplementation for cystic fibrosis. Cochrane Database of Syst Rev [Internet] 2014. http://onlinelibrary.wiley.com/ & doi:10.1002/14651858.CD007298.pub3/pdf [Available: 2017April 12].Green D, Carson K, Leonard A, et al. Current treatment recommendations for correcting vitamin D deficiency in paediatric patients with cystic fibrosis is inadequate. J Pediatr2008;4:554–559.Shepherd D, Belessis Y, Katz, et al. Single high-dose oral vitamin D3 (stoss) therapy: A solution to vitamin D deficiency in children with cystic fibrosis?J Cyst Fibros2013;2:177–182.

Promoting healthy nutrition

2019 ◽  
Author(s):  
Charlotte M. Wright
Keyword(s):  
Vitamin D ◽  
Preschool Children ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Complementary Feeding ◽  
Healthy Diet ◽  
Evidence Based ◽  
Healthy Nutrition

Key nutritional issues affecting preschool children discussed in this chapter are breastfeeding, complementary feeding, and promoting a healthy diet. The evidence on iron deficiency and vitamin D deficiency is reviewed. Recommendations are made for commissioning of services to support breastfeeding, and evidence-based advice given for practitioners.

scholarly journals Vitamin D deficiency and its treatment in cystic fibrosis

2019 ◽  
Vol 18 ◽  
pp. S66-S73 ◽  
Author(s):  
Tanicia Daley ◽  
Kara Hughan ◽  
Maria Rayas ◽  
Andrea Kelly ◽  
Vin Tangpricha
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency

scholarly journals 289 Vitamin D deficiency in patients attending the Tuscan regional cystic fibrosis centre

2013 ◽  
Vol 12 ◽  
pp. S122
Author(s):  
V. Galici ◽  
T. Repetto ◽  
A. Neri ◽  
C. Braggion ◽  
M. de Martino ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cystic Fibrosis Centre

scholarly journals Cystic Fibrosis Foundation Evidence-Based Guidelines for Management of Infants with Cystic Fibrosis

2009 ◽  
Vol 155 (6) ◽  
pp. S73-S93 ◽  
Author(s):  
Drucy Borowitz ◽  
Karen A. Robinson ◽  
Margaret Rosenfeld ◽  
Stephanie D. Davis ◽  
Kathryn A. Sabadosa ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Evidence Based ◽  
Cystic Fibrosis Foundation ◽  
Evidence Based Guidelines

Current Treatment Recommendations for Correcting Vitamin D Deficiency in Pediatric Patients with Cystic Fibrosis Are Inadequate

2008 ◽  
Vol 153 (4) ◽  
pp. 554-559.e2 ◽  
Author(s):  
Deanna Green ◽  
Kathryn Carson ◽  
Amanda Leonard ◽  
J. Erin Davis ◽  
Beryl Rosenstein ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pediatric Patients ◽  
Current Treatment ◽  
Treatment Recommendations

Vitamin D Deficiency Is Associated with Increased Nontuberculous Mycobacteria Risk in Cystic Fibrosis

2020 ◽  
Author(s):  
William J Richter ◽  
Yuqing Sun ◽  
Kevin J Psoter ◽  
Matthew N Santos ◽  
Jan A Nguyen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Nontuberculous Mycobacteria
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