scholarly journals Comprehensive assessment of the pharmacokinetic properties of a single bolus dose of colecalciferol in terms of efficacy and safety

2019 ◽  
Vol 22 (1) ◽  
pp. 4-9
Author(s):  
Liudmila A. Suplotova ◽  
Valeria A. Avdeeva ◽  
Ekaterina A. Pigarova ◽  
Liudmila Y. Rozhinskaya
Keyword(s):  
Vitamin D ◽  
Clinical Practice ◽  
Adverse Events ◽  
Vitamin D Deficiency ◽  
Calcium Metabolism ◽  
Bolus Dose ◽  
Efficacy And Safety ◽  
Single Bolus ◽  
Pharmacokinetic Properties ◽  
Single Bolus Dose

Background: The lack of a unified approach to the treatment of deficiency and vitamin D deficiency stimulated a detailed study of the dynamics of indicators of phosphorus-calcium metabolism, parathyroid hormone, 25(OH)D (calcidiol). Aim: To evaluate the pharmacokinetic properties of colecalciferol at a dosage of 150 000 IU, from the standpoint of its efficacy and safety in clinical practice. Materials and methods: Observational, single-center, prospective, selective, uncontrolled study of a comprehensive assessment of the pharmacokinetic properties of a single saturating dose of 150 000 IU of colecalciferol. To assess the pharmacokinetic properties of colecalciferol at a dosage of 150 000 IU, we set efficacy and safety criteria. The criterion for the effectiveness of treatment was to achieve an adequate level of vitamin D (more than 30 ng / ml at the initial insufficient level and more than 20 ng / ml for patients with vitamin D deficiency). The safety criteria for the correction of vitamin D deficiency or deficiency were the absence of patient complaints, adverse events and / or serious adverse events, as well as the preservation of the main laboratory parameters of phosphorus-calcium metabolism within the reference values. Results: When studying the efficacy of a dose of 150 000 IU in patients with vitamin D deficiency and insufficiency, it was found that the level of calcidiol was significantly higher in the group after treatment with colecalciferol compared with the group before treatment (p 0.05). The peak of the maximum value for patients with deficiency was established on the 14 day from the moment of administration of colecalciferol and was 37.1 6.28 ng / ml, and for patients with initial vitamin D deficiency 40.1 3.71 ng / ml. In the study of the safety of colecalciferol in a bolus dose of 150 000 IU, there were no statistically significant differences in the laboratory parameters of calcium-phosphorus metabolism, both in the group before treatment and after correction of deficiency and vitamin D insufficiency in both groups. Conclusion: Colecalciferol in the form of a single bolus dose of 150 000 IU demonstrated its efficacy and safety in real clinical practice.

Hypertension, Vitamin D Deficiency, and Calcium Metabolism

2012 ◽  
pp. 195-211
Author(s):  
M. Iftekhar Ullah ◽  
Christian A. Koch ◽  
Vin Tangpricha
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Calcium Metabolism

scholarly journals VITAMIN D DEFICIENCY AND PARATOHOMMONIUM INCREASE IN LATE POSTOPERATIVE GASTRIC BYPASS IN ROUX-EN-Y

2018 ◽  
Vol 31 (4) ◽  
Author(s):  
Daniela Vicinansa MÔNACO-FERREIRA ◽  
Vânia Aparecida LEANDRO-MERHI ◽  
Nilton César ARANHA ◽  
Andre BRANDALISE ◽  
Nelson Ary BRANDALISE
Keyword(s):  
Vitamin D ◽  
Gastric Bypass ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Serum Calcium ◽  
Calcium Metabolism ◽  
Calcium Deficiency ◽  
Ionized Calcium ◽  
Nutritional Deficiencies ◽  
Biochemical Tests

ABSTRACT Background : Roux-en-Y gastric bypass patients can experience changes in calcium metabolism and hyperparathyroidism secondary to vitamin D deficiency. Aim : To evaluate nutritional deficiencies related to the calcium metabolism of patients undergoing gastric bypass with a 10-year follow-up. Method : This is a longitudinal retrospective study of patients submitted to Roux-en-Y gastric bypass at a multidisciplinary clinic located in the Brazilian southeast region. The study investigated the results of the following biochemical tests: serum calcium, ionized calcium, vitamin D, and parathormone (PTH). The generalized estimating equations (GEE) determined the nutritional deficiencies using a significance level of 5%. Results : Among the patients who finished the study (120 months), 82.86% (n=29) had vitamin D deficiency, and 41.94% (n=13) had high PTH. Postoperative time had a significant effect on PTH (p=0.0059). The percentages of patients with vitamin D, serum calcium, and ionized calcium deficiencies did not change significantly over time. Conclusion : One of the outcomes was vitamin D deficiency associated with secondary hyperparathyroidism. These findings reaffirm the importance of monitoring the bone metabolism of patients submitted to Roux-en-Y gastric bypass. HEADINGS: Calcium deficiency. Vitamin D deficiency. Secondary hyperparathyroidism.

Cardiometabolic conditions could be related to vitamin D deficiency. The genetic determinants that affect vitamin D pathways may be solved with nanomedicines.

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Clinical Practice ◽  
Vitamin D Deficiency ◽  
Genetic Determinants ◽  
Bulk Materials ◽  
Treatment Regimens ◽  
Recent Developments

Vitamin D deficiency is a risk factor for cardiometabolic disorders.Nanomedicines can be used to treat atherosclerosis and associated ischemicdisorders. They are able to reduce internal clearance pathways and prolongblood circulation. They also have a large surface size and more sensitive andvaried reactivity than bulk materials, making them more effective at targetingand functionalizing nanoparticles for various types of disease. This studyfocuses on the specialized use of nanomedicine for atherosclerotic diseases inpreclinical and clinical practice. It presents the most recent developments innanomedicine-based treatment regimens for the disease. It has the potential tosolve the genetic determinants that influence vitamin D pathways.

THE ROLE OF VITAMIN D IN THE PATHOGENESIS OF THE ARTERIAL HYPERTENSION

2020 ◽  
Vol 65 (1) ◽  
pp. 5-10
Author(s):  
N. L. Lystsova ◽  
Tatiana Ivanovna Petelina ◽  
L. I. Gapon ◽  
K. S. Avdeeva ◽  
S. G. Bucova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Arterial Hypertension ◽  
Vitamin D Deficiency ◽  
Calcium Metabolism ◽  
Hormonal Status ◽  
Age Changes ◽  
Numerous Data ◽  
Mechanisms Of Development ◽  
The Relationship

In recent years, accumulated numerous data on the pathogenetic links of the formation of arterial hypertension. A number of studies have shown that vitamin D deficiency, associated with age, changes in sex hormonal status, increased tone of the renin-angiotensin-aldosterone system, endothelial dysfunction, and calcium metabolism, can be one of the mechanisms of development and progression of arterial hypertension. The purpose of the review was to summarize the results of the original domestic and foreign studies, prospective observations and meta-analyzes on the relationship between vitamin D deficiency and arterial hypertension.

scholarly journals Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study

2018 ◽  
Author(s):  
Sun-Joon Bai ◽  
Ki-Young Lee ◽  
Sung Soo Kim ◽  
Jung Hwa Hong ◽  
Hoon Jae Nam ◽  
...  
Keyword(s):  
General Anaesthesia ◽  
Bolus Dose ◽  
Controlled Study ◽  
Single Bolus ◽  
Quality Of Recovery ◽  
Single Bolus Dose ◽  
Pars Plana ◽  
Double Blinded ◽  
Operative Quality

There is a lack of data comparing sugammadex with anticholinesterase for the quality of anaesthesia recovery, especially following a single bolus dose of rocuronium. Thus, we evaluated the influence of reversal with sugammadex or neostigmine on post-operative quality of recovery by using the Post-operative Quality Recovery Scale (PQRS). A total of 86 patients undergoing trans-pars plana vitrectomy (TPPV) under general anaesthesia were intubated following a single bolus dose of rocuronium (0.6 mg/kg). At the end of surgery, patients were received either neostigmine or sugammadex. The quality of recovery was assessed using the PQRS at 15 minutes and 40 minutes after surgery, and on post-operative day 1. The recovery rate in the physiological domain was higher in the sugammadex group at 15 minutes after surgery (P = 0.02). Though there were no significant differences in the overall cognitive recovery domain, patients in the sugammadex group could recall more numbers in reverse order. However, there were no significant differences between the groups in the other domains of the PQRS. The use of sugammadex may increase the quality of the post-operative physiological recovery at early post-operative periods compared with neostigmine use following a single bolus dose of rocuronium in patients undergoing TPPV with general anaesthesia.

scholarly journals Verification of the Efficacy and Safety of Qi-Replenishing Chinese Medicine in Treating Prediabetes: A Meta-Analysis and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Shujie Xia ◽  
Bizhen Gao ◽  
Shujiao Chen ◽  
Xuejuan Lin ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Blood Glucose ◽  
Chinese Medicine ◽  
Adverse Events ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Postprandial Blood Glucose ◽  
Syndrome Differentiation ◽  
Efficacy And Safety ◽  
Subgroup Analyses

Background. Qi-replenishing Chinese medicines (QCMs) are used for treating prediabetes in the traditional Chinese medicine (TCM) clinical practice. The aims of this meta-analysis were to (i) verify the efficacy and safety of QCMs in treating prediabetes and (ii) investigate the clinical outcomes between the trials complying with and not complying with the principle of “syndrome differentiation.” Methods. We included only randomized controlled clinical trials (RCTs) whose Jadad scores were not less than 4. The overall clinical outcomes, including the incidence rate of diabetes, normalization of blood glucose, changes in fasting blood glucose (FBG), 2 h postprandial blood glucose, HbA1c, and occurrence of adverse events, were evaluated. Subgroup analyses were performed. Results. A total of 11 RCTs that enrolled 2210 patients with prediabetes were included. We observed that overall treatment with QCMs significantly ameliorated the clinical outcomes of prediabetes without increasing incidence of adverse events. The results of subgroup analyses revealed that prescribing QCMs complying with syndrome differentiation ameliorated all the clinical indices, whereas prescribing not complying with syndrome differentiation could not achieve significant amelioration in FBG and HbA1c levels. Furthermore, the subgroup with syndrome differentiation reported more adverse events. Conclusions. The overall results suggested that QCMs are effective and safe in treating prediabetes. Results of subgroup analyses indicated that the groups with syndrome differentiation presented better efficacy but had a higher occurrence of adverse events. This study indicated the important role of the principle of syndrome differentiation in TCM and that the adverse events of QCMs cannot be ignored in TCM clinical practice.

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