scholarly journals Anxiety: The Dizziness of Freedom—The Developmental Factors of Anxiety as Seen through the Lens of Psychoanalytic Thinking

2020 ◽  
Author(s):  
Peter Slater
Keyword(s):  
Developmental Factors

Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers

2019 ◽  
Vol 26 (11) ◽  
pp. 1994-2050 ◽  
Author(s):  
Annamaria Sandomenico ◽  
Menotti Ruvo
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Normal Development ◽  
Cancer Biomarkers ◽  
Normal Tissues ◽  
Tumor Relapse ◽  
Developmental Factors ◽  
Theranostic Agents ◽  
Tumor Types ◽  
Embryonic Signaling

Background:Elucidating the mechanisms of recurrence of embryonic signaling pathways in tumorigenesis has led to the discovery of onco-fetal players which have physiological roles during normal development but result aberrantly re-activated in tumors. In this context, Nodal and Cripto-1 are recognized as onco-developmental factors, which are absent in normal tissues but are overexpressed in several solid tumors where they can serve as theranostic agents.Objective:To collect, review and discuss the most relevant papers related to the involvement of Nodal and Cripto-1 in the development, progression, recurrence and metastasis of several tumors where they are over-expressed, with a particular attention to their occurrence on the surface of the corresponding sub-populations of cancer stem cells (CSC).Results:We have gathered, rationalized and discussed the most interesting findings extracted from some 370 papers related to the involvement of Cripto-1 and Nodal in all tumor types where they have been detected. Data demonstrate the clear connection between Nodal and Cripto-1 presence and their multiple oncogenic activities across different tumors. We have also reviewed and highlighted the potential of targeting Nodal, Cripto-1 and the complexes that they form on the surface of tumor cells, especially of CSC, as an innovative approach to detect and suppress tumors with molecules that block one or more mechanisms that they regulate.Conclusion:Overall, Nodal and Cripto-1 represent two innovative and effective biomarkers for developing potential theranostic anti-tumor agents that target normal as well as CSC subpopulations and overcome both pharmacological resistance and tumor relapse.

scholarly journals Interaction of developmental factors and ordinary stressful life events on brain structure in adults

2021 ◽  
pp. 102683
Author(s):  
Kai G. Ringwald ◽  
Tina Meller ◽  
Simon Schmitt ◽  
Till F.M. Andlauer ◽  
Frederike Stein ◽  
...  
Keyword(s):  
Life Events ◽  
Brain Structure ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Developmental Factors

scholarly journals Fine Mapping and Characterization of Linked Quantitative Trait Loci Involved in the Transition of the Maize Apical Meristem From Vegetative to Generative Structures

Genetics ◽  
1999 ◽  
Vol 153 (2) ◽  
pp. 993-1007 ◽  
Author(s):  
Cristian Vlăduţu ◽  
John McLaughlin ◽  
Ronald L Phillips
Keyword(s):  
Quantitative Trait ◽  
Positional Cloning ◽  
Apical Meristem ◽  
Node Number ◽  
Factors Affecting ◽  
Developmental Factors ◽  
Introgressed Segment ◽  
Determinate Growth ◽  
Trait Locus ◽  
Pollen Shed

AbstractQuantitative trait locus (QTL) mapping has detected two linked QTL in the 8L chromosome arm segment introgressed from Gaspé Flint (a Northern Flint open-pollinated population) into the background of N28 (a Corn Belt Dent inbred line). Homozygous recombinant lines, with a variable length of the introgressed segment, confirmed the presence of the two previously identified, linked QTL. In the N28 background, Gaspé Flint QTL alleles at both loci induce a reduction in node number, height, and days to anthesis (pollen shed). Given the determinate growth pattern of maize, the phenotypic effects indicate that the two QTL are involved in the transition of the apical meristem from vegetative to generative structures. Relative to the effects of the two QTL in the background of N28, we distinguish two general developmental factors affecting the timing of pollen shed. The primary factor is the timing of the transition of the apical meristem. The second, derivative factor is the global extent of internode elongation. Having separated the two linked QTL, we have laid the foundation for the positional cloning of the QTL with a larger effect.

scholarly journals Usability Testing for the Operation of a Mobile Robotic Telepresence System by Older Adults

2020 ◽  
Vol 64 (1) ◽  
pp. 1191-1195
Author(s):  
Samuel Olatunji ◽  
Andre Potenza ◽  
Tal Oron-Gilad ◽  
Andrey Kiselev ◽  
Amy Loutfi ◽  
...  
Keyword(s):  
Older Adults ◽  
Assisted Living ◽  
Usability Testing ◽  
Small Sample ◽  
Developmental Factors ◽  
Assistive Robot ◽  
Adult Participants ◽  
Autonomous Mode ◽  
Levels Of Automation ◽  
Local User

Mobile robotic telepresence (MRP) systems feature a video conferencing interface on a mobile robot, enabling pilot users to remotely control the robot while communicating with a local user. For older adults in an assisted living facility, the operators are mostly caregivers or remote family members. This small-sample usability testing aimed to evaluate the use of MRP by the older adult. Participants navigated the robot to locations in the home, e.g., to check if the front-door is closed. Two levels of automation were introduced; assisted teleoperation and autonomous. Observations revealed that the older adults enjoyed the dexterity with which the robot could be teleoperated in the assisted teleoperation mode. Yet, they preferred the operation of the MRP at the autonomous mode where the robot navigated autonomously towards the locations the user indicated. Usability, preference and objective findings raise awareness regarding elder care assistive robot developmental factors. Future experimental plans are discussed.

scholarly journals The PSY Peptide Family—Expression, Modification and Physiological Implications

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 218
Author(s):  
Amalie Scheel Tost ◽  
Astrid Kristensen ◽  
Lene Irene Olsen ◽  
Kristian Buhl Axelsen ◽  
Anja Thoe Fuglsang
Keyword(s):  
Plant Development ◽  
Higher Plants ◽  
Expression Patterns ◽  
Transcriptional Level ◽  
Amino Acid Peptide ◽  
Developmental Factors ◽  
Peptide Family ◽  
The Family ◽  
Modified Peptides ◽  
High Conservation

Small post-translationally modified peptides are gaining increasing attention as important signaling molecules in plant development. In the family of plant peptides containing tyrosine sulfation (PSYs), only PSY1 has been characterized at the mature level as an 18-amino-acid peptide, carrying one sulfated tyrosine, and involved in cell elongation. This review presents seven additional homologs in Arabidopsis all sharing high conservation in the active peptide domain, and it shows that PSY peptides are found in all higher plants and mosses. It is proposed that all eight PSY homologs are post-translationally modified to carry a sulfated tyrosine and that subtilisin-like subtilases (SBTs) are involved in the processing of PSY propeptides. The PSY peptides show differential expression patterns indicating that they serve several distinct functions in plant development. PSY peptides seem to be at least partly regulated at the transcriptional level, as their expression is greatly influenced by developmental factors. Finally, a model including a receptor in addition to PSY1R is proposed.

Cognitive-Developmental Factors in Children's Generosity

1974 ◽  
Vol 13 (3) ◽  
pp. 277-281 ◽  
Author(s):  
NICHOLAS P. EMLER ◽  
J. PHILIPPE RUSHTON
Keyword(s):  
Developmental Factors

Social Conditions of Mental Development

Diogenes ◽  
2019 ◽  
Vol 27 (1) ◽  
Author(s):  
Teodora Bedrozova-Petrova ◽  
◽  
◽  
Keyword(s):  
Human Development ◽  
Environmental Conditions ◽  
Mental Development ◽  
Social Conditions ◽  
Developmental Factors ◽  
Human Psyche

The developmental factors of heredity and environment form a complex union on the territory of the human psyche. The biological foundations of human development are merely the premise for its socially-driven deployment. This report focuses on some portions of the main aspects of mental development, the foundations of which lie in the environmental conditions.

scholarly journals Understanding the interplay of individual and social–developmental factors in the progression of substance use and mental health from childhood to adulthood

2016 ◽  
Vol 28 (3) ◽  
pp. 721-741 ◽  
Author(s):  
Tiffany M. Jones ◽  
Karl G. Hill ◽  
Marina Epstein ◽  
Jungeun Olivia Lee ◽  
J. David Hawkins ◽  
...  
Keyword(s):  
Mental Health ◽  
Substance Use ◽  
Social Environments ◽  
Developmental Factors ◽  
Substance Use Problems ◽  
History Of ◽  
Individual Functioning ◽  
Family History Of Depression ◽  
History Of Depression

AbstractThis study examines the interplay between individual and social–developmental factors in the development of positive functioning, substance use problems, and mental health problems. This interplay is nested within positive and negative developmental cascades that span childhood, adolescence, the transition to adulthood, and adulthood. Data are drawn from the Seattle Social Development Project, a gender-balanced, ethnically diverse community sample of 808 participants interviewed 12 times from ages 10 to 33. Path modeling showed short- and long-term cascading effects of positive social environments, family history of depression, and substance-using social environments throughout development. Positive family social environments set a template for future partner social environment interaction and had positive influences on proximal individual functioning, both in the next developmental period and long term. Family history of depression adversely affected mental health functioning throughout adulthood. Family substance use began a cascade of substance-specific social environments across development, which was the pathway through which increasing severity of substance use problems flowed. The model also indicated that adolescent, but not adult, individual functioning influenced selection into positive social environments, and significant cross-domain effects were found in which substance-using social environments affected subsequent mental health.

Some Common Myths About Voice Therapy

1992 ◽  
Vol 23 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Mary Pannbacker
Keyword(s):  
Voice Disorders ◽  
Voice Therapy ◽  
Perceptual Cues ◽  
Developmental Factors

There are many concepts about voice therapy that are at best, misleading and at worst, incorrect. Through this review, it is hoped that some of these misconceptions will be resolved. Issues reviewed include developmental factors, iatrogenic voice disorders, breathing habits, optimum pitch, palate training, and etiology based on perceptual cues.

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