scholarly journals Advanced Treatments and Emerging Therapies for Dystrophin- Deficient Cardiomyopathies

10.5772/65061 ◽  
2017 ◽  
Author(s):  
Jordi Camps ◽  
Enrico Pozzo ◽  
Tristan Pulinckx ◽  
Robin Duelen ◽  
Maurilio Sampaolesi
Keyword(s):  
Emerging Therapies ◽  
Advanced Treatments

scholarly journals Emerging Therapies for Acute Ischemic Stroke

Stroke ◽  
2003 ◽  
Vol 34 (2) ◽  
pp. 359-361 ◽  
Author(s):  
Marc Fisher ◽  
Thomas G. Brott
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Emerging Therapies

scholarly journals Oxidative Stress and Inflammation in Renal and Cardiovascular Complications of Diabetes

Biology ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 18
Author(s):  
Amelia Charlton ◽  
Jessica Garzarella ◽  
Karin A. M. Jandeleit-Dahm ◽  
Jay C. Jha
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Tissue Injury ◽  
Cardiovascular Complications ◽  
Therapeutic Strategies ◽  
Cellular Damage ◽  
Antioxidant Defenses ◽  
Pathological State ◽  
Oxygen Species ◽  
Emerging Therapies

Oxidative stress and inflammation are considered major drivers in the pathogenesis of diabetic complications, including renal and cardiovascular disease. A symbiotic relationship also appears to exist between oxidative stress and inflammation. Several emerging therapies target these crucial pathways, to alleviate the burden of the aforementioned diseases. Oxidative stress refers to an imbalance between reactive oxygen species (ROS) and antioxidant defenses, a pathological state which not only leads to direct cellular damage but also an inflammatory cascade that further perpetuates tissue injury. Emerging therapeutic strategies tackle these pathways in a variety of ways, from increasing antioxidant defenses (antioxidants and Nrf2 activators) to reducing ROS production (NADPH oxidase inhibitors and XO inhibitors) or inhibiting the associated inflammatory pathways (NLRP3 inflammasome inhibitors, lipoxins, GLP-1 receptor agonists, and AT-1 receptor antagonists). This review summarizes the mechanisms by which oxidative stress and inflammation contribute to and perpetuate diabetes associated renal and cardiovascular disease along with the therapeutic strategies which target these pathways to provide reno and cardiovascular protection in the setting of diabetes.

Emerging therapies for atopic dermatitis: JAK inhibitors

2018 ◽  
Vol 78 (3) ◽  
pp. S53-S62 ◽  
Author(s):  
David G. Cotter ◽  
David Schairer ◽  
Lawrence Eichenfield
Keyword(s):  
Atopic Dermatitis ◽  
Jak Inhibitors ◽  
Emerging Therapies
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