Advanced Treatments in ENT Disorders

2019 ◽  
2021 ◽  
pp. 175319342110308
Author(s):  
Toshiyasu Nakamura ◽  
Pak Cheong Ho ◽  
Andrea Atzei ◽  
Fernando Corella ◽  
Jan-Ragnar Haugstvedt

Recent technical and technological developments in wrist arthroscopic surgery allow for advanced treatments of difficult wrist disorders. In this review, world leaders of wrist arthroscopy describe bone graft for scaphoid nonunion, transosseous repair for triangular fibrocartilage fovea avulsion, palmaris longus reconstruction of the triangular fibrocartilage, and arthroscopic reconstruction of the scapholunate and lunotriquetral ligaments.


1996 ◽  
Vol 17 (4) ◽  
pp. 128-134
Author(s):  
Gregory S. Liptak

The Challenge Pediatric care has become exceedingly complex, but no matter how technologically advanced treatments become, they can be only as effective as compliance with their use. Compliance, or adherence, defined as the extent to which a person's behavior coincides with medical or health advice, is crucial for the treatment of illness, the prevention of disease, and the promotion of health. Unfortunately, noncompliance is extremely common. For example, in a study of the use of penicillin for acute otitis media and "strep" throat, Charney et al1 found that only 43% of the children complied with the regimen. Gordis and associates2 found that compliance with penicillin used for chronic rheumatic fever prophylaxis was only 36%. Eney and Goldstein3 showed that compliance with theophylline in children being evaluated in an emergency department for asthma was only 11%. Compliance decreases over the course of treatment, not only for long-term interventions, but for brief ones as well. For example, Bergman and Werner4 found that 56% of individuals being treated with penicillin for streptococcal pharyngitis had stopped taking the medication by day 3, 71% by day 6, and 82% by day 9 of the treatment course. Although compliance is so important, it is largely neglected in medical education, including pediatric residency training.


Author(s):  
Nadia Morin-Crini ◽  
Eric Lichtfouse ◽  
Marc Fourmentin ◽  
Ana Rita Lado Ribeiro ◽  
Constantinos Noutsopoulos ◽  
...  

2007 ◽  
Vol 32 (6) ◽  
pp. 510-510
Author(s):  
E. Barr ◽  
J. Dungworth ◽  
K. Hunter ◽  
M. McFarlane ◽  
H. Kubba

2018 ◽  
Vol 115 (26) ◽  
pp. 6685-6690 ◽  
Author(s):  
Anthony Kulesa ◽  
Jared Kehe ◽  
Juan E. Hurtado ◽  
Prianca Tawde ◽  
Paul C. Blainey

Combinatorial drug treatment strategies perturb biological networks synergistically to achieve therapeutic effects and represent major opportunities to develop advanced treatments across a variety of human disease areas. However, the discovery of new combinatorial treatments is challenged by the sheer scale of combinatorial chemical space. Here, we report a high-throughput system for nanoliter-scale phenotypic screening that formulates a chemical library in nanoliter droplet emulsions and automates the construction of chemical combinations en masse using parallel droplet processing. We applied this system to predict synergy between more than 4,000 investigational and approved drugs and a panel of 10 antibiotics againstEscherichia coli, a model gram-negative pathogen. We found a range of drugs not previously indicated for infectious disease that synergize with antibiotics. Our validated hits include drugs that synergize with the antibiotics vancomycin, erythromycin, and novobiocin, which are used against gram-positive bacteria but are not effective by themselves to resolve gram-negative infections.


Author(s):  
Jordi Camps ◽  
Enrico Pozzo ◽  
Tristan Pulinckx ◽  
Robin Duelen ◽  
Maurilio Sampaolesi

Author(s):  
Patricia Maani Fogelman ◽  
Janine A. Gerringer

The care of the cardiac patient requires exquisite assessment including history, physical examinations, and diagnostic data in order to make differential diagnoses and formulate individualized treatment plans. Interventions include education about lifestyle modifications, the introduction and titration of cardiac medications, and referral for more advanced treatments such as vasoactive or inotropic medications, cardiovascular implantable electronic devices, and ventricular assist devices. Often, patients decide to discontinue these therapies. Standardized protocols for withdrawal of life-sustaining respiratory therapies provide structured guidance, reduce variation in practice, and improve satisfaction of families and healthcare providers. This chapter reviews such therapies and the process for cessation while simultaneously attending to symptom management.


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