scholarly journals Implication of Regional Activation of Toll-Like Receptor 3/ Interferon-β Signaling in Human Mesangial Cells — Possible Involvement in the Pathogenesis of Lupus Nephritis

10.5772/59756 ◽  
2015 ◽  
Author(s):  
Hiroshi Tanaka ◽  
Kazushi Tsuruga ◽  
Tadaatsu Imaizumi
Keyword(s):  
Lupus Nephritis ◽  
Mesangial Cells ◽  
Toll Like Receptor ◽  
Interferon Β ◽  
Human Mesangial Cells

Toll-like receptor 3 signaling contributes to the expression of a neutrophil chemoattractant, CXCL1 in human mesangial cells

2014 ◽  
Vol 19 (5) ◽  
pp. 761-770 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Tomomi Aizawa ◽  
Chihiro Segawa ◽  
Michiko Shimada ◽  
Kazushi Tsuruga ◽  
...  
Keyword(s):  
Mesangial Cells ◽  
Toll Like Receptor ◽  
Human Mesangial Cells

Glomerular expression of myxovirus resistance protein 1 in human mesangial cells: Possible activation of innate immunity in the pathogenesis of lupus nephritis

Nephrology ◽  
2013 ◽  
Vol 18 (12) ◽  
pp. 833-837 ◽  
Author(s):  
Shojiro Watanabe ◽  
Tadaatsu Imaizumi ◽  
Kazushi Tsuruga ◽  
Tomomi Aizawa ◽  
Tatsuya Ito ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Lupus Nephritis ◽  
Mesangial Cells ◽  
Human Mesangial Cells ◽  
Resistance Protein

scholarly journals Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

2017 ◽  
Vol 42 (5) ◽  
pp. 942-950 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Ryo Hayakari ◽  
Shojiro Watanabe ◽  
Tomomi Aizawa ◽  
Tomoh Matsumiya ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mesangial Cells ◽  
Toll Like Receptor ◽  
Inflammatory Signaling ◽  
Human Mesangial Cells

Vascular and glomerular expression of endothelin-1 in normal human kidney

1998 ◽  
Vol 275 (1) ◽  
pp. F8-F17 ◽  
Author(s):  
William H. Herman ◽  
Steven N. Emancipator ◽  
R. L. Patrick Rhoten ◽  
Michael S. Simonson
Keyword(s):  
Protein Kinase ◽  
Lupus Nephritis ◽  
Phorbol Ester ◽  
Mesangial Cells ◽  
Human Kidney ◽  
Human Mesangial Cells ◽  
Endothelin 1 ◽  
Normal Human Kidney ◽  
Normal Human ◽  
Tgf Β1

To understand better the function of endothelin-1 (ET-1) in renal physiology, we examined vascular and glomerular expression of ET-1 in normal human kidney and in lupus nephritis. Immunohistochemical analysis revealed that renal endothelium of glomeruli, arteries, veins, and capillaries expressed ET-1. Endothelial cells were the principal source of glomerular ET-1; positive immunostaining was detected only rarely in mesangial cells and vascular smooth muscle cells from normal kidney. However, mesangial staining for ET-1 was elevated in patients with lupus nephritis, suggesting that under certain conditions mesangial cells elaborate ET-1. Indeed cultured human mesangial cells from normal subjects secreted ET-1 peptide. ET-1 secretion was augmented by the protein kinase C activator phorbol ester and by transforming growth factor-β1 (TGF-β1), a cytokine implicated in the development of glomerulosclerosis. Transient transfection of cultured mesangial cells with a preproET-1 reporter construct showed that the preproET-1 promoter is transcriptionally active in mesangial cells and is stimulated by TGF-β1, phorbol ester, or ectopic expression of protein kinase β1. Cultured human mesangial cells have both ETA and ETB receptors that contribute to ET-1-stimulated mitogenesis. Taken together, these results demonstrate that ET-1 is expressed at sites where paracrine or autocrine signaling by ET-1 might control renal vasoconstriction, glomerular filtration rate, and remodeling of the glomerulus in renal disease.

Interaction between Interferon-Stimulated Gene 56 and Melanoma Differentiation-Associated Gene 5 in Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells

2013 ◽  
Vol 37 (2) ◽  
pp. 118-125 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Tomomi Aizawa-Yashiro ◽  
Tomoh Matsumiya ◽  
Hidemi Yoshida ◽  
Shojiro Watanabe ◽  
...  
Keyword(s):  
Mesangial Cells ◽  
Toll Like Receptor ◽  
Human Mesangial Cells ◽  
Normal Human
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