Glomerular expression of myxovirus resistance protein 1 in human mesangial cells: Possible activation of innate immunity in the pathogenesis of lupus nephritis

Nephrology ◽  
2013 ◽  
Vol 18 (12) ◽  
pp. 833-837 ◽  
Author(s):  
Shojiro Watanabe ◽  
Tadaatsu Imaizumi ◽  
Kazushi Tsuruga ◽  
Tomomi Aizawa ◽  
Tatsuya Ito ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Lupus Nephritis ◽  
Mesangial Cells ◽  
Human Mesangial Cells ◽  
Resistance Protein

Vascular and glomerular expression of endothelin-1 in normal human kidney

1998 ◽  
Vol 275 (1) ◽  
pp. F8-F17 ◽  
Author(s):  
William H. Herman ◽  
Steven N. Emancipator ◽  
R. L. Patrick Rhoten ◽  
Michael S. Simonson
Keyword(s):  
Protein Kinase ◽  
Lupus Nephritis ◽  
Phorbol Ester ◽  
Mesangial Cells ◽  
Human Kidney ◽  
Human Mesangial Cells ◽  
Endothelin 1 ◽  
Normal Human Kidney ◽  
Normal Human ◽  
Tgf Β1

To understand better the function of endothelin-1 (ET-1) in renal physiology, we examined vascular and glomerular expression of ET-1 in normal human kidney and in lupus nephritis. Immunohistochemical analysis revealed that renal endothelium of glomeruli, arteries, veins, and capillaries expressed ET-1. Endothelial cells were the principal source of glomerular ET-1; positive immunostaining was detected only rarely in mesangial cells and vascular smooth muscle cells from normal kidney. However, mesangial staining for ET-1 was elevated in patients with lupus nephritis, suggesting that under certain conditions mesangial cells elaborate ET-1. Indeed cultured human mesangial cells from normal subjects secreted ET-1 peptide. ET-1 secretion was augmented by the protein kinase C activator phorbol ester and by transforming growth factor-β1 (TGF-β1), a cytokine implicated in the development of glomerulosclerosis. Transient transfection of cultured mesangial cells with a preproET-1 reporter construct showed that the preproET-1 promoter is transcriptionally active in mesangial cells and is stimulated by TGF-β1, phorbol ester, or ectopic expression of protein kinase β1. Cultured human mesangial cells have both ETA and ETB receptors that contribute to ET-1-stimulated mitogenesis. Taken together, these results demonstrate that ET-1 is expressed at sites where paracrine or autocrine signaling by ET-1 might control renal vasoconstriction, glomerular filtration rate, and remodeling of the glomerulus in renal disease.

Chloroquine attenuates TLR3/IFN-β signaling in cultured normal human mesangial cells: A possible protective effect against renal damage in lupus nephritis

2017 ◽  
Vol 27 (6) ◽  
pp. 1004-1009 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Ryo Hayakari ◽  
Tomoh Matsumiya ◽  
Hidemi Yoshida ◽  
Kazushi Tsuruga ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Protective Effect ◽  
Renal Damage ◽  
Mesangial Cells ◽  
Human Mesangial Cells ◽  
Normal Human

Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-?B-mediated expression in cultured human mesangial cells

2004 ◽  
Vol 8 (3) ◽  
pp. 196-205 ◽  
Author(s):  
Tomoko Tsukinoki ◽  
Hitoshi Sugiyama ◽  
Reiko Sunami ◽  
Mizuho Kobayashi ◽  
Tetsuya Onoda ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Fas Ligand ◽  
Mesangial Cell ◽  
Mesangial Cells ◽  
Human Mesangial Cells

scholarly journals Melanoma Differentiation-Associated Gene 5 Regulates the Expression of a Chemokine CXCL10 in Human Mesangial Cells: Implications for Chronic Inflammatory Renal Diseases

2012 ◽  
Vol 228 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Tomomi Aizawa-Yashiro ◽  
Kazushi Tsuruga ◽  
Hiroshi Tanaka ◽  
Tomoh Matsumiya ◽  
...  
Keyword(s):  
Mesangial Cells ◽  
Renal Diseases ◽  
Human Mesangial Cells
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