scholarly journals Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

2016 ◽  
Vol 41 (5) ◽  
pp. 635-642 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Chikashi Yano ◽  
Akiko Numata ◽  
Koji Tsugawa ◽  
Ryo Hayakari ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mesangial Cells ◽  
Type I Interferon ◽  
Type I ◽  
Toll Like Receptor ◽  
Inflammatory Signaling ◽  
Human Mesangial Cells

scholarly journals Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

2017 ◽  
Vol 42 (5) ◽  
pp. 942-950 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Ryo Hayakari ◽  
Shojiro Watanabe ◽  
Tomomi Aizawa ◽  
Tomoh Matsumiya ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mesangial Cells ◽  
Toll Like Receptor ◽  
Inflammatory Signaling ◽  
Human Mesangial Cells

Toll-like receptor 3 signaling contributes to the expression of a neutrophil chemoattractant, CXCL1 in human mesangial cells

2014 ◽  
Vol 19 (5) ◽  
pp. 761-770 ◽  
Author(s):  
Tadaatsu Imaizumi ◽  
Tomomi Aizawa ◽  
Chihiro Segawa ◽  
Michiko Shimada ◽  
Kazushi Tsuruga ◽  
...  
Keyword(s):  
Mesangial Cells ◽  
Toll Like Receptor ◽  
Human Mesangial Cells

scholarly journals Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes

2018 ◽  
Vol 19 (10) ◽  
pp. 2890 ◽  
Author(s):  
Elias Sayour ◽  
Hector Mendez-Gomez ◽  
Duane Mitchell
Keyword(s):  
Immune Suppression ◽  
Cancer Vaccines ◽  
Type I Interferon ◽  
Type I ◽  
Toll Like Receptor ◽  
Adaptive Responses ◽  
Receptor Stimulation ◽  
Delivery Vehicles ◽  
Therapeutic Settings

Cancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes can serve as a more immunogenic and expeditious trigger of anti-tumor immunity. RNA stimulates innate immunity through toll like receptor stimulation producing type I interferon, and it mediates potent adaptive responses. Since RNA is inherently unstable, delivery systems have been developed to protect and deliver it to intended targets in vivo. In this review, we discuss liposomes as RNA delivery vehicles and their role as cancer vaccines.

scholarly journals Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis

2005 ◽  
Vol 85 (7) ◽  
pp. 908-920 ◽  
Author(s):  
Yasushi Takii ◽  
Minoru Nakamura ◽  
Masahiro Ito ◽  
Terufumi Yokoyama ◽  
Atsumasa Komori ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Type I Interferon ◽  
Type I ◽  
Biliary Cirrhosis ◽  
Toll Like Receptor ◽  
Enhanced Expression
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