scholarly journals Adult Mesenchymal Stem Cells in Current Tissue Engineering Concepts

10.5772/59219 ◽  
2014 ◽  
Author(s):  
Susanne Jung ◽  
Johannes Kleinheinz
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adult Mesenchymal Stem Cells

scholarly journals Preparation of Organ Scaffolds by Decellularization of Pancreas and Re-functionalization

2019 ◽  
Author(s):  
K Uday Chandrika ◽  
Rekha Tripathi ◽  
T Avinash Raj ◽  
N. Sairam ◽  
Vasundhara Kamineni Parliker ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Extracellular Matrix ◽  
Mesenchymal Stem Cells ◽  
Functional Recovery ◽  
Diabetic Mice ◽  
Normal Functioning ◽  
C Peptide ◽  
Adult Mesenchymal Stem Cells ◽  
The Status

AbstractExtracellular matrix of each tissue is unique in composition, architecture and finer details that support the very identity of the organ by regulating the status/character of the cells within it. Tissue engineering centers around creating a niche similar to the natural one, with a purpose of developing an organ/oid. In this study, whole organ decellularization of pancreas was attempted followed by reseeding it with adult mesenchymal stem cells. Decellularization completely removes cells leaving behind extracellular matrix rich scaffold. After reseeding, mesenchymal stem cells differentiate into pancreas specific cells. Upon transplantation of recellularized pancreas in streptozotocin induced diabetic mice, this organ was capable of restoring its histomorphology and normal functioning. Restoration of endocrine islets, the exocrine acinar region, and vascular network was seen in transplanted pancreas. The entire process of functional recovery took about 20 days when the mice demonstrated glucoregulation, though none achieved gluconormalization. Transplanted mice upon feeding show insulin and c-peptide in circulation. This process demonstrates that natural scaffolds of soft organs can be refunctionalized using recipients cells to counter immune problems arising due to organ transplantation.

scholarly journals Application of adult mesenchymal stem cells in bone and vascular tissue engineering

2018 ◽  
Author(s):  
Martina Trávníčková ◽  
Lucie Bačáková
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Vascular Tissue ◽  
Positive Influence ◽  
Clinical Applications ◽  
Medium Composition ◽  
Advantages And Disadvantages ◽  
Tissue Replacement ◽  
Adult Mesenchymal Stem Cells

Tissue engineering is a very promising field of regenerative medicine. Life expectancy has been increasing, and tissue replacement is increasingly needed in patients suffering from various degenerative disorders of the organs. The use of adult mesenchymal stem cells (e.g. from adipose tissue or from bone marrow) in tissue engineering seems to be a promising approach for tissue replacements. Clinical applications can make direct use of the large secretome of these cells, which can have a positive influence on other cells around. Another advantage of adult mesenchymal stem cells is the possibility to differentiate them into various mature cells via appropriate culture conditions (i.e. medium composition, biomaterial properties, and dynamic conditions). This review is focused on current and future ways to carry out tissue replacement of damaged bones and blood vessels, especially with the use of suitable adult mesenchymal stem cells as a potential source of differentiated mature cells that can later be used for tissue replacement. The advantages and disadvantages of different stem cell sources are discussed, with a main focus on adipose-derived stem cells. Patient factors that can influence later clinical applications are taken into account.

scholarly journals Superior Osteogenic Capacity for Bone Tissue Engineering of Fetal Compared with Perinatal and Adult Mesenchymal Stem Cells

Stem Cells ◽  
2009 ◽  
Vol 27 (1) ◽  
pp. 126-137 ◽  
Author(s):  
Zhi-Yong Zhang ◽  
Swee-Hin Teoh ◽  
Mark S.K. Chong ◽  
Jan Thorsten Schantz ◽  
Nicholas M. Fisk ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Adult Mesenchymal Stem Cells
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