scholarly journals Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

2007 ◽  
Vol 213 (2) ◽  
pp. 341-347 ◽  
Author(s):  
Arnold I. Caplan
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Adult Mesenchymal Stem Cells

scholarly journals Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review

2018 ◽  
Vol 18 (3) ◽  
pp. 264 ◽  
Author(s):  
Roberto Berebichez-Fridman ◽  
Pablo R. Montero-Olvera
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Adult Stem Cells ◽  
Current Knowledge ◽  
Clinical Applications ◽  
The Body ◽  
Differentiation Potential ◽  
Advantages And Disadvantages

First discovered by Friedenstein in 1976, mesenchymal stem cells (MSCs) are adult stem cells found throughout the body that share a fixed set of characteristics. Discovered initially in the bone marrow, this cell source is considered the gold standard for clinical research, although various other sources—including adipose tissue, dental pulp, mobilised peripheral blood and birth-derived tissues—have since been identified. Although similar, MSCs derived from different sources possess distinct characteristics, advantages and disadvantages, including their differentiation potential and proliferation capacity, which influence their applicability. Hence, they may be used for specific clinical applications in the fields of regenerative medicine and tissue engineering. This review article summarises current knowledge regarding the various sources, characteristics and therapeutic applications of MSCs.Keywords: Mesenchymal Stem Cells; Adult Stem Cells; Regenerative Medicine; Cell Differentiation; Tissue Engineering.

scholarly journals Mesenchymal stem cells in regenerative medicine: Opportunities and challenges for articular cartilage and intervertebral disc tissue engineering

2010 ◽  
Vol 222 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Stephen M. Richardson ◽  
Judith A. Hoyland ◽  
Reza Mobasheri ◽  
Constanze Csaki ◽  
Mehdi Shakibaei ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Intervertebral Disc ◽  
Disc Tissue

scholarly journals Valproic Acid Promotes Early Neural Differentiation in Adult Mesenchymal Stem Cells Through Protein Signalling Pathways

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 619 ◽  
Author(s):  
Jerran Santos ◽  
Thibaut Hubert ◽  
Bruce K Milthorpe
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Neural Differentiation ◽  
Clinical Applications ◽  
Janus Kinase ◽  
Fibroblast Growth Factor 21 ◽  
Neural Cells ◽  
Adult Mesenchymal Stem Cells

Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell types applicable for regenerative medicine (specifically neural cells, using chemicals). Valproic acid was an ideal candidate due to its clinical stability. It has been implicated in the induction of neural differentiation; however, the mechanism and the downstream events were not known. In this study, we showed that using valproic acid on adult mesenchymal stem cells induced neural differentiation within 24 h by upregulating the expression of suppressor of cytokine signaling 5 (SOCS5) and Fibroblast growth factor 21 (FGF21), without increasing the potential death rate of the cells. Through this, the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is downregulated, and the mitogen-activated protein kinase (MAPK) cascade is activated. The bioinformatics analyses revealed the expression of several neuro-specific proteins as well as a range of functional and structural proteins involved in the formation and development of the neural cells.

scholarly journals Amniotic membrane and its epithelial and mesenchymal stem cells as an appropriate source for skin tissue engineering and regenerative medicine

2018 ◽  
Vol 46 (sup2) ◽  
pp. 431-440 ◽  
Author(s):  
Behrouz Farhadihosseinabadi ◽  
Mehrdad Farahani ◽  
Tahereh Tayebi ◽  
Ameneh Jafari ◽  
Felor Biniazan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Amniotic Membrane ◽  
Skin Tissue ◽  
Skin Tissue Engineering

Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine

Life Sciences ◽  
2020 ◽  
Vol 256 ◽  
pp. 118002 ◽  
Author(s):  
Maria Maqsood ◽  
Mingzhu Kang ◽  
Xiaotao Wu ◽  
Jinghua Chen ◽  
Liping Teng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Adult Mesenchymal Stem Cells
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