scholarly journals Epigenetic Reprogramming in Stem Cells

10.5772/56327 ◽  
2013 ◽  
Author(s):  
Richard L. ◽  
Yasin Kizilyer ◽  
Candace L.
Keyword(s):  
Stem Cells ◽  
Epigenetic Reprogramming

scholarly journals Epigenetic Reprogramming of Human Embryonic Stem Cells into Skeletal Muscle Cells and Generation of Contractile Myospheres

Cell Reports ◽  
2013 ◽  
Vol 3 (3) ◽  
pp. 661-670 ◽  
Author(s):  
Sonia Albini ◽  
Paula Coutinho ◽  
Barbora Malecova ◽  
Lorenzo Giordani ◽  
Alex Savchenko ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Muscle Cells ◽  
Epigenetic Reprogramming ◽  
Skeletal Muscle Cells

scholarly journals Germ Line, Stem Cells, and Epigenetic Reprogramming

2008 ◽  
Vol 73 (0) ◽  
pp. 9-15 ◽  
Author(s):  
M.A. Surani ◽  
G. Durcova-Hills ◽  
P. Hajkova ◽  
K. Hayashi ◽  
W.W. Tee
Keyword(s):  
Stem Cells ◽  
Germ Line ◽  
Epigenetic Reprogramming

scholarly journals Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition

2016 ◽  
Vol 6 (11) ◽  
pp. 1248-1257 ◽  
Author(s):  
Mary T. Scott ◽  
Koorosh Korfi ◽  
Peter Saffrey ◽  
Lisa E.M. Hopcroft ◽  
Ross Kinstrie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tyrosine Kinase ◽  
Epigenetic Reprogramming ◽  
Kinase Inhibition ◽  
Tyrosine Kinase Inhibition

scholarly journals Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops

2021 ◽  
Author(s):  
João C. Sabino ◽  
Madalena R. de Almeida ◽  
Patricia L. Abreu ◽  
Ana M. Ferreira ◽  
Marco M. Domingues ◽  
...  
Keyword(s):  
Stem Cells ◽  
Regulation Of Gene Expression ◽  
Embryonic Stem ◽  
Wide Distribution ◽  
Epigenetic Reprogramming ◽  
Loop Formation ◽  
Genome Wide ◽  
Dna Strand ◽  
Tet Enzymes ◽  
Template Dna

AbstractDNA oxidation by ten-eleven translocation (TET) family enzymes is essential for epigenetic reprogramming. The conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) initiates developmental and cell-type-specific transcriptional programs through mechanisms that include changes in the chromatin structure. Here, we show that the presence of 5hmC in the transcribed DNA promotes the annealing of the nascent RNA to its template DNA strand, leading to the formation of an R-loop. The genome-wide distribution of 5hmC and R-loops show a positive correlation in mouse and human embryonic stem cells and overlap in half of all active genes. Moreover, R-loop resolution leads to differential expression of a subset of genes that are involved in crucial events during stem cell proliferation. Altogether, our data reveal that epigenetic reprogramming via TET activity promotes co-transcriptional R-loop formation, and disclose novel links between R-loops and the regulation of gene expression programs in stem cells.

scholarly journals Epigenetic reprogramming by naïve conditions establishes an irreversible state of partial X chromosome reactivation in female stem cells

Oncotarget ◽  
2018 ◽  
Vol 9 (38) ◽  
pp. 25136-25147 ◽  
Author(s):  
Alexandra V. Panova ◽  
Alexandra N. Bogomazova ◽  
Maria A. Lagarkova ◽  
Sergey L. Kiselev
Keyword(s):  
Stem Cells ◽  
X Chromosome ◽  
Epigenetic Reprogramming
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