scholarly journals Treatment of Bone Defects — Allogenic Platelet Gel and Autologous Bone Technique

10.5772/55987 ◽  
2013 ◽  
Author(s):  
Dragica Smrke ◽  
Primo Roman ◽  
Matja Veselko ◽  
Borut Gubi
Keyword(s):  
Bone Defects ◽  
Platelet Gel ◽  
Autologous Bone

scholarly journals Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study

2021 ◽  
Vol 11 (1) ◽  
pp. 395
Author(s):  
Antonio Scarano ◽  
Francesco Inchingolo ◽  
Biagio Rapone ◽  
Alberta Greco Lucchina ◽  
Erda Qorri ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
New Bone Formation ◽  
Platelet Gel ◽  
Woven Bone ◽  
Rapid Healing ◽  
Rabbit Bone ◽  
Autologous Platelet ◽  
New Zealand Rabbits

Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (p < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects.

Reconstruction of the glenoid using autologous bone-graft and the SMR Axioma TT metal-backed prosthesis

2018 ◽  
Vol 100-B (12) ◽  
pp. 1609-1617 ◽  
Author(s):  
A. M. Malhas ◽  
J. Granville-Chapman ◽  
P. M. Robinson ◽  
S. Brookes-Fazakerley ◽  
M. Walton ◽  
...  
Keyword(s):  
Bone Graft ◽  
Reliable Method ◽  
Titanium Surface ◽  
Bone Defects ◽  
Autologous Bone Graft ◽  
Short Term ◽  
Bone Deficiency ◽  
Autologous Bone ◽  
Shoulder Arthroplasties

Aims We present our experience of using a metal-backed prosthesis and autologous bone graft to treat gross glenoid bone deficiency. Patients and Methods A prospective cohort study of the first 45 shoulder arthroplasties using the SMR Axioma Trabecular Titanium (TT) metal-backed glenoid with autologous bone graft. Between May 2013 and December 2014, 45 shoulder arthroplasties were carried out in 44 patients with a mean age of 64 years (35 to 89). The indications were 23 complex primary arthroplasties, 12 to revise a hemiarthroplasty or resurfacing, five for aseptic loosening of the glenoid, and five for infection. Results Of the 45 patients, 16 had anatomical shoulder arthroplasties (ASA) and 29 had reverse shoulder arthroplasties (RSA). Postoperatively, 43/45 patients had a CT scan. In 41 of 43 patients (95%), the glenoid peg achieved > 50% integration. In 40 of 43 cases (93%), the graft was fully or partially integrated. There were seven revisions (16%) but only four (9%) required a change of baseplate. Four (25%) of the 16 ASAs were revised for instability or cuff failure. At two-year radiological follow-up, five of the 41 cases (11%) showed some evidence of lucent lines. Conclusion The use of a metal baseplate with a trabecular titanium surface in conjunction with autologous bone graft is a reliable method of addressing glenoid bone defects in primary and revision RSA setting in the short term. ASAs have a higher rate of complications with this technique.

scholarly journals Restoration of Critical-Sized Defects in the Rabbit Mandible Using Autologous Bone Marrow Stromal Cells Hybridized with Nano-β-tricalcium Phosphate/Collagen Scaffolds

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Xuehui Zhang ◽  
Mingming Xu ◽  
Xinggang Liu ◽  
Feng Zhang ◽  
Yan Wei ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Tricalcium Phosphate ◽  
Bone Marrow Stromal Cells ◽  
Autologous Bone Marrow ◽  
Bone Defects ◽  
Marrow Stromal Cells ◽  
Collagen Scaffolds ◽  
Autologous Bone

Nano-β-tricalcium phosphate/collagen (n-β-TCP/Col) is considered with good osteoconductivity. However, the therapeutic effectiveness of n-β-TCP/Col scaffolds in combination with autologous bone marrow stromal cells (BMSCs) remains to be elucidated for the repair of critical-sized bone defects. In this study, we found that n-β-TCP/Col scaffolds exhibited high biocompatibilityin vitro. The introduction of BMSCs expandedin vitroto the scaffolds dramatically enhanced their efficiency to restore critical-sized bone defects, especially during the initial stage after implantation. Collectively, these results suggest that autologous BMSCs in n-β-TCP/Col scaffolds have the potential to be applied in bone tissue engineering.

Resynthesis of sternal dehiscence with autologous bone graft and autologous platelet gel

2012 ◽  
Vol 21 (2) ◽  
pp. 74-77 ◽  
Author(s):  
M. Lusini ◽  
A. Di Martino ◽  
C. Spadaccio ◽  
A. Rainer ◽  
M. Chello ◽  
...  
Keyword(s):  
Bone Graft ◽  
Autologous Bone Graft ◽  
Platelet Gel ◽  
Sternal Dehiscence ◽  
Autologous Bone ◽  
Autologous Platelet

scholarly journals Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement

2017 ◽  
Vol 28 (3) ◽  
pp. 287-295 ◽  
Author(s):  
Paola Castro de Moraes ◽  
Isabela Cristina de Souza Marques ◽  
Fernanda Gonçalves Basso ◽  
Hebert Luis Rossetto ◽  
Fernanda de Carvalho Panzeri Pires-de-Souza ◽  
...  
Keyword(s):  
Calcium Aluminate ◽  
Bone Repair ◽  
Repair Process ◽  
Bone Defects ◽  
Calcium Aluminate Cement ◽  
Histopathological Analysis ◽  
Body Type ◽  
Significant Difference ◽  
Autologous Bone ◽  
Aluminate Cement

Abstract Innovative biomaterials can provide a promising new direction for the treatment of bone defects, stimulating a proper repair process, with no damage to adjacent tissues. The purpose of this in vivo study was to evaluate the biocompatibility and the osteoinductive capacity of chitosan-collagen biomembrane and scaffold containing calcium aluminate cement. Eighteen New Zealand white rabbits (Oryctolagus cuniculus) were distributed according to the experimental times of analysis (7, 15 and 30 days). Four bone defects were created in the rabbits calvaria, which were individually filled with the biomembrane, scaffold, blood clot (negative control) and autologous bone (positive control). Histopathological analysis was performed using optical microscope at 32´, 64´, 125´ and 320´ magnifications. Cell response to inflammation and new bone tissue formation was quantified using a score system. The biomembrane group presented greater inflammatory response at 15 days, with significant difference to autologous bone group (p<0.05). There was no statistically significant difference for foreign body type reaction among groups (p>0.05). Concerning new bone formation, linear closure of the defect area was observed more evidently in the group with autologous bone. The scaffold group presented similar results compared with the autologous bone group at 30 days (p>0.05). Both tested biomaterials presented similar biocompatibility compared with the control groups. In addition, the biomembrane and scaffold presented similar osteoinductive capacity, stimulating bone repair process in the course of the experimental time intervals.

Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs

Injury ◽  
2010 ◽  
Vol 41 (7) ◽  
pp. 717-723 ◽  
Author(s):  
M. Hakimi ◽  
P. Jungbluth ◽  
M. Sager ◽  
M. Betsch ◽  
M. Herten ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Bone Grafts ◽  
Bone Defects ◽  
Long Bone ◽  
Combined Use ◽  
Autologous Bone ◽  
Autologous Bone Grafts ◽  
Mini Pigs

scholarly journals Repair of orbital bone defects in canines using grafts of enriched autologous bone marrow stromal cells

2014 ◽  
Vol 12 (1) ◽  
pp. 123 ◽  
Author(s):  
Yefei Wang ◽  
Xiaoping Bi ◽  
Huifang Zhou ◽  
Yuan Deng ◽  
Jing Sun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Autologous Bone Marrow ◽  
Bone Defects ◽  
Marrow Stromal Cells ◽  
Autologous Bone

scholarly journals Reaming debris as a novel source of autologous bone to enhance healing of bone defects

2011 ◽  
Vol 97A (4) ◽  
pp. 457-465 ◽  
Author(s):  
Astrid D. Bakker ◽  
Robert Jan Kroeze ◽  
Clara Korstjens ◽  
Ruben H. de Kleine ◽  
Jan Paul M. Frölke ◽  
...  
Keyword(s):  
Bone Defects ◽  
Autologous Bone
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