scholarly journals Reaming debris as a novel source of autologous bone to enhance healing of bone defects

2011 ◽  
Vol 97A (4) ◽  
pp. 457-465 ◽  
Author(s):  
Astrid D. Bakker ◽  
Robert Jan Kroeze ◽  
Clara Korstjens ◽  
Ruben H. de Kleine ◽  
Jan Paul M. Frölke ◽  
...  
Keyword(s):  
Bone Defects ◽  
Autologous Bone

Reconstruction of the glenoid using autologous bone-graft and the SMR Axioma TT metal-backed prosthesis

2018 ◽  
Vol 100-B (12) ◽  
pp. 1609-1617 ◽  
Author(s):  
A. M. Malhas ◽  
J. Granville-Chapman ◽  
P. M. Robinson ◽  
S. Brookes-Fazakerley ◽  
M. Walton ◽  
...  
Keyword(s):  
Bone Graft ◽  
Reliable Method ◽  
Titanium Surface ◽  
Bone Defects ◽  
Autologous Bone Graft ◽  
Short Term ◽  
Bone Deficiency ◽  
Autologous Bone ◽  
Shoulder Arthroplasties

Aims We present our experience of using a metal-backed prosthesis and autologous bone graft to treat gross glenoid bone deficiency. Patients and Methods A prospective cohort study of the first 45 shoulder arthroplasties using the SMR Axioma Trabecular Titanium (TT) metal-backed glenoid with autologous bone graft. Between May 2013 and December 2014, 45 shoulder arthroplasties were carried out in 44 patients with a mean age of 64 years (35 to 89). The indications were 23 complex primary arthroplasties, 12 to revise a hemiarthroplasty or resurfacing, five for aseptic loosening of the glenoid, and five for infection. Results Of the 45 patients, 16 had anatomical shoulder arthroplasties (ASA) and 29 had reverse shoulder arthroplasties (RSA). Postoperatively, 43/45 patients had a CT scan. In 41 of 43 patients (95%), the glenoid peg achieved > 50% integration. In 40 of 43 cases (93%), the graft was fully or partially integrated. There were seven revisions (16%) but only four (9%) required a change of baseplate. Four (25%) of the 16 ASAs were revised for instability or cuff failure. At two-year radiological follow-up, five of the 41 cases (11%) showed some evidence of lucent lines. Conclusion The use of a metal baseplate with a trabecular titanium surface in conjunction with autologous bone graft is a reliable method of addressing glenoid bone defects in primary and revision RSA setting in the short term. ASAs have a higher rate of complications with this technique.

scholarly journals Restoration of Critical-Sized Defects in the Rabbit Mandible Using Autologous Bone Marrow Stromal Cells Hybridized with Nano-β-tricalcium Phosphate/Collagen Scaffolds

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Xuehui Zhang ◽  
Mingming Xu ◽  
Xinggang Liu ◽  
Feng Zhang ◽  
Yan Wei ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Tricalcium Phosphate ◽  
Bone Marrow Stromal Cells ◽  
Autologous Bone Marrow ◽  
Bone Defects ◽  
Marrow Stromal Cells ◽  
Collagen Scaffolds ◽  
Autologous Bone

Nano-β-tricalcium phosphate/collagen (n-β-TCP/Col) is considered with good osteoconductivity. However, the therapeutic effectiveness of n-β-TCP/Col scaffolds in combination with autologous bone marrow stromal cells (BMSCs) remains to be elucidated for the repair of critical-sized bone defects. In this study, we found that n-β-TCP/Col scaffolds exhibited high biocompatibilityin vitro. The introduction of BMSCs expandedin vitroto the scaffolds dramatically enhanced their efficiency to restore critical-sized bone defects, especially during the initial stage after implantation. Collectively, these results suggest that autologous BMSCs in n-β-TCP/Col scaffolds have the potential to be applied in bone tissue engineering.

scholarly journals Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement

2017 ◽  
Vol 28 (3) ◽  
pp. 287-295 ◽  
Author(s):  
Paola Castro de Moraes ◽  
Isabela Cristina de Souza Marques ◽  
Fernanda Gonçalves Basso ◽  
Hebert Luis Rossetto ◽  
Fernanda de Carvalho Panzeri Pires-de-Souza ◽  
...  
Keyword(s):  
Calcium Aluminate ◽  
Bone Repair ◽  
Repair Process ◽  
Bone Defects ◽  
Calcium Aluminate Cement ◽  
Histopathological Analysis ◽  
Body Type ◽  
Significant Difference ◽  
Autologous Bone ◽  
Aluminate Cement

Abstract Innovative biomaterials can provide a promising new direction for the treatment of bone defects, stimulating a proper repair process, with no damage to adjacent tissues. The purpose of this in vivo study was to evaluate the biocompatibility and the osteoinductive capacity of chitosan-collagen biomembrane and scaffold containing calcium aluminate cement. Eighteen New Zealand white rabbits (Oryctolagus cuniculus) were distributed according to the experimental times of analysis (7, 15 and 30 days). Four bone defects were created in the rabbits calvaria, which were individually filled with the biomembrane, scaffold, blood clot (negative control) and autologous bone (positive control). Histopathological analysis was performed using optical microscope at 32´, 64´, 125´ and 320´ magnifications. Cell response to inflammation and new bone tissue formation was quantified using a score system. The biomembrane group presented greater inflammatory response at 15 days, with significant difference to autologous bone group (p<0.05). There was no statistically significant difference for foreign body type reaction among groups (p>0.05). Concerning new bone formation, linear closure of the defect area was observed more evidently in the group with autologous bone. The scaffold group presented similar results compared with the autologous bone group at 30 days (p>0.05). Both tested biomaterials presented similar biocompatibility compared with the control groups. In addition, the biomembrane and scaffold presented similar osteoinductive capacity, stimulating bone repair process in the course of the experimental time intervals.

Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs

Injury ◽  
2010 ◽  
Vol 41 (7) ◽  
pp. 717-723 ◽  
Author(s):  
M. Hakimi ◽  
P. Jungbluth ◽  
M. Sager ◽  
M. Betsch ◽  
M. Herten ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Bone Grafts ◽  
Bone Defects ◽  
Long Bone ◽  
Combined Use ◽  
Autologous Bone ◽  
Autologous Bone Grafts ◽  
Mini Pigs

scholarly journals Repair of orbital bone defects in canines using grafts of enriched autologous bone marrow stromal cells

2014 ◽  
Vol 12 (1) ◽  
pp. 123 ◽  
Author(s):  
Yefei Wang ◽  
Xiaoping Bi ◽  
Huifang Zhou ◽  
Yuan Deng ◽  
Jing Sun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Autologous Bone Marrow ◽  
Bone Defects ◽  
Marrow Stromal Cells ◽  
Autologous Bone

A Histological and Radiological Study of Bone Formation around Porous Resorbable β-Tricalcium Phosphate Used as Bone Defect Filling

2014 ◽  
Vol 631 ◽  
pp. 420-425
Author(s):  
M. Strnadová ◽  
T. Kučera ◽  
M.D. Cevallos Lecaro ◽  
J. Strnad ◽  
Z. Strnad ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Metallic Material ◽  
Bone Graft Substitutes ◽  
Autologous Bone ◽  
Benign Tumours ◽  
Autologous Bone Grafts ◽  
Defect Filling

The purpose of this study was to analyze the histological, histochemical and radiological findings gained from pre-clinical in vitro and in vivo tests and from implantation of ß-tricalcium phosphate PORESORB®-TCP (P). (P) is a bioactive, resorbable, inorganic, crystalline, non-metallic material with osseoconductive properties intended for replacement of bone tissue. The (P) granules (size 1-2mm) were implanted into the tibia of dogs for 3 and 6 months. The formation of 53% and 72% of new bone was observed after 3 and 6 months respectively.Material (P) sized 0.3-0.6 mm was used to fill in the periodontal defect and also as a carrier of growth proteins. During the study period, no undesired response to the material used was observed. The values of the plaque index showed standard hygienic conditions – the values of PlI were 0.72, 0.65 and 0.62 before treatment and 6 and 12 months after treatment, respectively.A total of 72 two-stage sinus lifts were performed in 54 patients. The autologous bone was harvested from the mandibular ramus and mixed with the (P) material sized 1-2 mm. The materials were used in a proportion ranging between 1: 1 and 1: 3. The residual allograft area was 16.21 ± 8.78 %. The connective tissue was 44.16 ± 5.85 %.This has been a retrospective review of the healing of bone defects, due to benign tumours or tumour-like lesions, using (P) material sized 1.3 mm, 0.7 mm (0.6-2 mm) as bone graft substitutes. 87 patients with bone defects (average volume 15 cm3; interval 0.4 – 144 cm3) were included. Defects with a volume up to 4 cm3 had the same successful rate of healing both for autologous bone grafts and (P). (P) sized 1.3 mm; 0.7 mm (0.6-2 mm) was successfully used in defects with volume up to 4 cm3. However, it is evident that the ratio of the size of the defect and the size of the applied granule must be kept near to 10/1 for successful treatment.

scholarly journals Low Dose BMP2-Doped Calcium Phosphate Graft Promotes Bone Defect Healing in a Large Animal Model

2021 ◽  
Vol 8 ◽  
Author(s):  
Tie Liu ◽  
Wen Fang ◽  
Gang Wu ◽  
Yining Li ◽  
Janak L. Pathak ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Low Dose ◽  
Bone Defects ◽  
Autologous Bone Graft ◽  
Large Animal Model ◽  
Large Animal ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
Autologous Bone

Background: Bone grafts are in high demand due to the increase in the cases of bone defects mainly caused by trauma, old age, and disease-related bone damages. Tissue-engineered calcium phosphate (CaP) biomaterials match the major inorganic contents of bone, thereby could be the potential bone graft substitute. However, CaP-bone grafts lack the osteoinductivity that is vital for effective bone regeneration. In this study, we aimed to test the bone defect healing potential of biomimetically fabricated low dose BMP2-doped CaP (BMP2.BioCaP) grafts in a large animal model.Methods: Low dose BMP2 was doped internally (BMP2-int.BioCaP) or on the surface of CaP (BMP2-sur.BioCaP) grafts during the fabrication process. Our previous study showed the robust bone regenerative potential of BMP2-int.BioCaP and BMP2-sur.BioCaP grafts in the rat ectopic model. In this study, we investigated the bone defect healing potential of BMP2.BioCaP grafts in sheep humerus/femoral defects, as well as compared with that of autologous bone graft and clinically used deproteinized bovine bone (DBB) xenograft.Results: Different ways of BMP2 doping did not affect the surface morphology and degradation properties of the graft materials. Micro-CT and histology results showed robustly higher bone defect-healing potential of the BMP2.BioCaP grafts compared to clinically used DBB grafts. The bone defect healing potential of BMP2.BioCaP grafts was as effective as that of the autologous bone graft. Although, BMP2-int.BioCaP doped half the amount of BMP2 compared to BMP2-sur.BioCaP, its' bone defect healing potential was even robust. The BMP2.BioCaP grafts showed less immunogenicity compared to BioCaP or DBB grafts. The volume density of blood vessel-like and bone marrow-like structures in both BMP2.BioCaP graft groups were in a similar extent to the autologous group. Meticulous observation of higher magnification histological images showed active bone regeneration and remodeling during bone defect healing in BMP2.BioCaP graft groups.Conclusion: The robust bone regenerative potential of BMP2.BioCaP grafts in the ectopic model and in-situ bone defects in small and large animals warrant the pre-clinical studies on large animal critical-sized segmental bone defects.

Sign in / Sign up

Export Citation Format

Share Document