scholarly journals Delivery Systems and Role of Growth Factors for Alveolar Bone Regeneration in Dentistry

10.5772/55580 ◽  
2013 ◽  
Author(s):  
Stefano Sivolella ◽  
Marleen De ◽  
Giulia Brunello ◽  
Sara Ricci ◽  
Drazen Tadic ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Regeneration ◽  
Alveolar Bone ◽  
Delivery Systems

Role of growth factors in bone regeneration

2020 ◽  
Vol 7 (3) ◽  
pp. 69
Author(s):  
Ankit Agarwal ◽  
Nisha Singh ◽  
Mohsin Khan ◽  
SamirSahib Merajun Nabi Khan ◽  
Kush Sahu ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Regeneration

scholarly journals Role of fibroblast growth factors in bone regeneration

2017 ◽  
Vol 37 (1) ◽  
Author(s):  
Pornkawee Charoenlarp ◽  
Arun Kumar Rajendran ◽  
Sachiko Iseki
Keyword(s):  
Growth Factors ◽  
Bone Regeneration ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth

scholarly journals The Role of Epigenetic Functionalization of Implants and Biomaterials in Osseointegration and Bone Regeneration—A Review

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5879
Author(s):  
Farah Asa’ad ◽  
Goda Pelanyte ◽  
Jincy Philip ◽  
Christer Dahlin ◽  
Lena Larsson
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Inflammatory Diseases ◽  
Standards Of Care ◽  
Epigenetic Mechanisms ◽  
Implant Surface ◽  
The Past ◽  
Need To Evaluate ◽  
Specific Search

The contribution of epigenetic mechanisms as a potential treatment model has been observed in cancer and autoimmune/inflammatory diseases. This review aims to put forward the epigenetic mechanisms as a promising strategy in implant surface functionalization and modification of biomaterials, to promote better osseointegration and bone regeneration, and could be applicable for alveolar bone regeneration and osseointegration in the future. Materials and Methods: Electronic and manual searches of the literature in PubMed, MEDLINE, and EMBASE were conducted, using a specific search strategy limited to publications in the last 5 years to identify preclinical studies in order to address the following focused questions: (i) Which, if any, are the epigenetic mechanisms used to functionalize implant surfaces to achieve better osseointegration? (ii) Which, if any, are the epigenetic mechanisms used to functionalize biomaterials to achieve better bone regeneration? Results: Findings from several studies have emphasized the role of miRNAs in functionalizing implants surfaces and biomaterials to promote osseointegration and bone regeneration, respectively. However, there are scarce data on the role of DNA methylation and histone modifications for these specific applications, despite being commonly applied in cancer research. Conclusions: Studies over the past few years have demonstrated that biomaterials are immunomodulatory rather than inert materials. In this context, epigenetics can act as next generation of advanced treatment tools for future regenerative techniques. Yet, there is a need to evaluate the efficacy/cost effectiveness of these techniques in comparison to current standards of care.

scholarly journals Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling

2020 ◽  
Vol 6 (24) ◽  
pp. eaba7602
Author(s):  
Ziad Julier ◽  
Rezvan Karami ◽  
Bhavana Nayer ◽  
Yen-Zhen Lu ◽  
Anthony J. Park ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factors ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Interleukin 1 ◽  
Delivery Systems ◽  
Regenerative Capacity ◽  
Local Inhibition ◽  
Signaling Dynamics ◽  
Regenerative Activity

Although growth factors (GFs) are key molecules for regenerative medicine, their use has been limited by issues associated with suboptimal delivery systems and incomplete understanding of their signaling dynamics. Here, we explored how proinflammatory signals affect GF regenerative potential. Using bone regeneration in mouse, we found that the regenerative capacity of two clinically relevant GFs (BMP-2 and PDGF-BB) is impaired by interleukin-1 receptor (IL-1R1). Mechanistically, IL-1R1 activation in bone-forming cells desensitizes them to GFs and accelerates senescence. Moreover, administration of the GFs triggers IL-1 release by macrophages. To provide localized and sustained IL-1R1 inhibition, we engineered IL-1R antagonist (IL-1Ra) to bind the extracellular matrix (ECM) very strongly and demonstrate that codelivering GFs with ECM-binding IL-1Ra induces superior regeneration. Thus, we highlight that GF regenerative activity is hindered by proinflammatory signals, and GF-based therapies should integrate immunomodulation. Particularly, ECM-binding IL-1Ra holds clinical translational potential by enhancing efficacy of GF therapies.

scholarly journals Nanotechnology Scaffolds for Alveolar Bone Regeneration

Materials ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 201 ◽  
Author(s):  
Goker Funda ◽  
Silvio Taschieri ◽  
Giannì Aldo Bruno ◽  
Emma Grecchi ◽  
Savadori Paolo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Alveolar Bone ◽  
Publication Date ◽  
Reference List ◽  
Tissue Formation ◽  
Key Factors ◽  
Nanofibrous Scaffolds ◽  
Key Events

In oral biology, tissue engineering aims at regenerating functional tissues through a series of key events that occur during alveolar/periodontal tissue formation and growth, by means of scaffolds that deliver signaling molecules and cells. Due to their excellent physicochemical properties and biomimetic features, nanomaterials are attractive alternatives offering many advantages for stimulating cell growth and promoting tissue regeneration through tissue engineering. The main aim of this article was to review the currently available literature to provide an overview of the different nano-scale scaffolds as key factors of tissue engineering for alveolar bone regeneration procedures. In this narrative review, PubMed, Medline, Scopus and Cochrane electronic databases were searched using key words like “tissue engineering”, “regenerative medicine”, “alveolar bone defects”, “alveolar bone regeneration”, “nanomaterials”, “scaffolds”, “nanospheres” and “nanofibrous scaffolds”. No limitation regarding language, publication date and study design was set. Hand-searching of the reference list of identified articles was also undertaken. The aim of this article was to give a brief introduction to review the role of different nanoscaffolds for bone regeneration and the main focus was set to underline their role for alveolar bone regeneration procedures.

scholarly journals The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Wen Du ◽  
Wei Du ◽  
Haiyang Yu
Keyword(s):  
Growth Factors ◽  
Alveolar Bone ◽  
Tooth Development ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth ◽  
Dental Tissues ◽  
Mineralized Tissues ◽  
Calcified Tissue ◽  
Mouse Incisor

The mineralized tissue of the tooth is composed of enamel, dentin, cementum, and alveolar bone; enamel is a calcified tissue with no living cells that originates from oral ectoderm, while the three other tissues derive from the cranial neural crest. The fibroblast growth factors (FGFs) are critical during the tooth development. Accumulating evidence has shown that the formation of dental tissues, that is, enamel, dentin, and supporting alveolar bone, as well as the development and homeostasis of the stem cells in the continuously growing mouse incisor is mediated by multiple FGF family members. This review discusses the role of FGF signaling in these mineralized tissues, trying to separate its different functions and highlighting the crosstalk between FGFs and other signaling pathways.

scholarly journals The role of synthetic biomaterials in resorptive alveolar bone regeneration

2007 ◽  
Vol 61 (2) ◽  
pp. 96-100
Author(s):  
Biljana Kalicanin ◽  
Zorica Ajdukovic ◽  
Milena Kostic ◽  
Stevo Najman ◽  
Vojin Savic ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Significant Role ◽  
Alveolar Bone ◽  
Phosphate Content ◽  
Synthetic Material ◽  
Nano Composite ◽  
Mandibular Bone

The alveolar bone tissue resorption defect has a significant role in dentistry. Because of the bone tissue deficit developed by alveolar resorption, the use of synthetic material CP/PLGA (calcium-phosphate/polylactide-co-gliycolide) composite was introduced. Investigations were performed on rats with artificially produced resorption of the mandibular bone. The results show that the best effect on alveolar bone were attained by using nano-composite implants. The effect of the nanocomposite was ascertained by determining the calcium and phosphate content, as a basis of the hydroxyapatite structure. The results show that synthetic CP/PLGA nanocomposite alleviate the rehabilitation of weakened alveolar bone. Due to its osteoconductive effect, CP/PLGA can be the material of choice for bone substitution in the future.

1386: Role of Seminal Growth Factors in Infertile Men with Varicocele

2004 ◽  
Vol 171 (4S) ◽  
pp. 365-365
Author(s):  
Tamer M. Said ◽  
Shyam Allamaneni ◽  
Kiran P. Nallella ◽  
Rakesh K. Sharma ◽  
Mohamed A. Bedaiwy ◽  
...  
Keyword(s):  
Growth Factors ◽  
Infertile Men
Sign in / Sign up

Export Citation Format

Share Document