scholarly journals The role of synthetic biomaterials in resorptive alveolar bone regeneration

2007 ◽  
Vol 61 (2) ◽  
pp. 96-100
Author(s):  
Biljana Kalicanin ◽  
Zorica Ajdukovic ◽  
Milena Kostic ◽  
Stevo Najman ◽  
Vojin Savic ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Significant Role ◽  
Alveolar Bone ◽  
Phosphate Content ◽  
Synthetic Material ◽  
Nano Composite ◽  
Mandibular Bone

The alveolar bone tissue resorption defect has a significant role in dentistry. Because of the bone tissue deficit developed by alveolar resorption, the use of synthetic material CP/PLGA (calcium-phosphate/polylactide-co-gliycolide) composite was introduced. Investigations were performed on rats with artificially produced resorption of the mandibular bone. The results show that the best effect on alveolar bone were attained by using nano-composite implants. The effect of the nanocomposite was ascertained by determining the calcium and phosphate content, as a basis of the hydroxyapatite structure. The results show that synthetic CP/PLGA nanocomposite alleviate the rehabilitation of weakened alveolar bone. Due to its osteoconductive effect, CP/PLGA can be the material of choice for bone substitution in the future.

scholarly journals Delivery Systems and Role of Growth Factors for Alveolar Bone Regeneration in Dentistry

10.5772/55580 ◽  
2013 ◽  
Author(s):  
Stefano Sivolella ◽  
Marleen De ◽  
Giulia Brunello ◽  
Sara Ricci ◽  
Drazen Tadic ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Regeneration ◽  
Alveolar Bone ◽  
Delivery Systems

Impact of Calcium Phosphate Particle Morphology on Osteoconduction: an In Vivo Study

2007 ◽  
Vol 361-363 ◽  
pp. 1237-1240 ◽  
Author(s):  
Christophe Drouet ◽  
Ronan Barré ◽  
Gérard Brunel ◽  
Gérard Dechambre ◽  
Edmond Benqué ◽  
...  
Keyword(s):  
Hydrothermal Synthesis ◽  
Chemical Composition ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Particle Morphology ◽  
In Vivo Study ◽  
Total Absence

Apatite/β−TCP particles exhibiting non-conventional urchin-like morphology were prepared by hydrothermal synthesis. Their implantation in the rat calvarium was followed during 60 days. A total absence of osteoconduction was observed despite a favorable chemical composition, stressing the fundamental role of particle morphology on bone regeneration. Results are discussed in relation with other literature data. Possible explanations include the disfavored accumulation of biological mediators due to the acicular shape of the particles and/or a limited accessibility for cells.

scholarly journals Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair

2021 ◽  
Author(s):  
Gilyana Kazakova ◽  
Tatiana Safronova ◽  
Daniil Golubchikov ◽  
Olga Shevtsova ◽  
Julietta Rau
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
Tissue Repair ◽  
Early Stage ◽  
Biological Properties ◽  
Magnesium Ions ◽  
Comprehensive Overview ◽  
Phosphate Ions ◽  
Great Relevance

Materials based on Mg2+-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play a significant role in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. Here we pro-vide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction. The role of magnesium ions in angiogene-sis, an important process associated with osteogenesis, is considered. Finally, the biological properties of magnesium phosphates for bone regeneration are summarized. They show promis-ing results in terms of use as bone replacement material.

Five Years Clinical Follow Up Bone Regeneration with CaP Bioceramics

2007 ◽  
Vol 361-363 ◽  
pp. 1339-1342 ◽  
Author(s):  
Clemencia Rodríguez ◽  
Alain Jean ◽  
Sylvia Mitja ◽  
G. Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Bone Ingrowth ◽  
X Ray ◽  
Dental Implantation ◽  
Preventive Method

To overcome autograft use for dental implantation, it is important to prevent bone loss after tooth extraction or to restore alveolar bone level after pathological diseases. Biphasic calcium phosphate (BCP), mixture of HA and ß-TCP, have proven its performance in orthopaedic, while few studies have been reported in dentistry. We reported 5 years clinical follow up on bone regeneration after immediate dental root filling. MBCP 60/40 and MBCP 20/80 are biphasic CaP intimate mixture of HA/TCP 60/40 and 20/80; with interconnected macroporosity and microporosity. Forty cases have been distributed in two groups for alveolar pocket filling. Seven cases without filling are used as control. X-Ray at 0, 3, 6, 12 months and 5 years follow up for some patients were performed. In all the 40 cases, radio-opacity of the implantation area decreases on time, indicating resorption and bone ingrowths at the expense of the two bioceramics. No difference in the resorption kinetics appeared on X-Ray. After 1 year, the implantation area looks as physiological bone and is maintained on time. The newly formed bone is preserved after 5 years contrarily to the controls cases (without filling)where we observed decrease of 2 to 5 mm. This study demonstrated that immediate filling of alveolar pocket after tooth extraction is a preventive method of the jaw bone resorption. After long term (other one year) resorption and bone ingrowth were demonstrated for both micro and macroporous biphasic calcium phosphate with two different HA/TCP ratio.

scholarly journals The Role of Epigenetic Functionalization of Implants and Biomaterials in Osseointegration and Bone Regeneration—A Review

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5879
Author(s):  
Farah Asa’ad ◽  
Goda Pelanyte ◽  
Jincy Philip ◽  
Christer Dahlin ◽  
Lena Larsson
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Inflammatory Diseases ◽  
Standards Of Care ◽  
Epigenetic Mechanisms ◽  
Implant Surface ◽  
The Past ◽  
Need To Evaluate ◽  
Specific Search

The contribution of epigenetic mechanisms as a potential treatment model has been observed in cancer and autoimmune/inflammatory diseases. This review aims to put forward the epigenetic mechanisms as a promising strategy in implant surface functionalization and modification of biomaterials, to promote better osseointegration and bone regeneration, and could be applicable for alveolar bone regeneration and osseointegration in the future. Materials and Methods: Electronic and manual searches of the literature in PubMed, MEDLINE, and EMBASE were conducted, using a specific search strategy limited to publications in the last 5 years to identify preclinical studies in order to address the following focused questions: (i) Which, if any, are the epigenetic mechanisms used to functionalize implant surfaces to achieve better osseointegration? (ii) Which, if any, are the epigenetic mechanisms used to functionalize biomaterials to achieve better bone regeneration? Results: Findings from several studies have emphasized the role of miRNAs in functionalizing implants surfaces and biomaterials to promote osseointegration and bone regeneration, respectively. However, there are scarce data on the role of DNA methylation and histone modifications for these specific applications, despite being commonly applied in cancer research. Conclusions: Studies over the past few years have demonstrated that biomaterials are immunomodulatory rather than inert materials. In this context, epigenetics can act as next generation of advanced treatment tools for future regenerative techniques. Yet, there is a need to evaluate the efficacy/cost effectiveness of these techniques in comparison to current standards of care.

scholarly journals Photobiomodulation Therapy on the Guided Bone Regeneration Process in Defects Filled by Biphasic Calcium Phosphate Associated with Fibrin Biopolymer

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 847
Author(s):  
Bruna Botteon Della Coletta ◽  
Thiago Borges Jacob ◽  
Luana Aparecida de Carvalho Moreira ◽  
Karina Torres Pomini ◽  
Daniela Vieira Buchaim ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Biphasic Calcium Phosphate ◽  
Bone Growth ◽  
Guided Bone Regeneration ◽  
Photobiomodulation Therapy ◽  
Regeneration Process ◽  
Positive Effects ◽  
Significant Difference

The aim is to evaluate the effects of photobiomodulation therapy (PBMT) on the guided bone regeneration process (GBR) in defects in the calvaria of rats filled with biphasic calcium phosphate associated with fibrin biopolymer. Thirty male Wistar rats were randomly separated: BMG (n = 10), defects filled with biomaterial and covered by membrane; BFMG (n = 10), biomaterial and fibrin biopolymer covered by membrane; and BFMLG (n = 10), biomaterial and fibrin biopolymer covered by membrane and biostimulated with PBMT. The animals were euthanized at 14 and 42 days postoperatively. Microtomographically, in 42 days, there was more evident bone growth in the BFMLG, limited to the margins of the defect with permanence of the particles. Histomorphologically, an inflammatory infiltrate was observed, which regressed with the formation of mineralized bone tissue. In the quantification of bone tissue, all groups had a progressive increase in new bone tissue with a significant difference in which the BFMLG showed greater bone formation in both periods (10.12 ± 0.67 and 13.85 ± 0.54), followed by BFMG (7.35 ± 0.66 and 9.41 ± 0.84) and BMG (4.51 ± 0.44 and 7.11 ± 0.44). Picrosirius-red staining showed greater birefringence of collagen fibers in yellow-green color in the BFMLG, showing more advanced bone maturation. PBMT showed positive effects capable of improving and accelerating the guided bone regeneration process when associated with biphasic calcium phosphate and fibrin biopolymer.

scholarly journals Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xin Huang ◽  
Donghua Huang ◽  
Ting Zhu ◽  
Xiaohua Yu ◽  
Kaicheng Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Metal Ions ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Cell Fate ◽  
Metal Ion ◽  
Healing Process

AbstractMetal ions have been identified as important bone metabolism regulators and widely used in the field of bone tissue engineering, however their exact role during bone regeneration remains unclear. Herein, the aim of study was to comprehensively explore the interactions between osteoinductive and osteo-immunomodulatory properties of these metal ions. In particular, the osteoinductive role of zinc ions (Zn2+), as well as its interactions with local immune microenvironment during bone healing process, was investigated in this study using a sustained Zn2+ delivery system incorporating Zn2+ into β-tricalcium phosphate/poly(L-lactic acid) (TCP/PLLA) scaffolds. The presence of Zn2+ largely enhanced osteogenic differentiation of periosteum-derived progenitor cells (PDPCs), which was coincident with increased transition from M1 to M2 macrophages (M$$\varphi $$ φ s). We further confirmed that induction of M2 polarization by Zn2+ was realized via PI3K/Akt/mTOR pathway, whereas marker molecules on this pathway were strictly regulated by the addition of Zn2+. Synergically, this favorable immunomodulatory effect of Zn2+ further improved the osteogenic differentiation of PDPCs induced by Zn2+ in vitro. Consistently, the spontaneous osteogenesis and pro-healing osteoimmunomodulation of the scaffolds were thoroughly identified in vivo using a rat air pouch model and a calvarial critical-size defect model. Taken together, Zn2+-releasing bioactive ceramics could be ideal scaffolds in bone tissue engineering due to their reciprocal interactions between osteoinductive and immunomodulatory characteristics. Clarification of this synergic role of Zn2+ during osteogenesis could pave the way to develop more sophisticated metal-ion based orthopedic therapeutic strategies.

scholarly journals Aligned Nanofiber-Guided Bone Regeneration Barrier Incorporated with Equine Bone-Derived Hydroxyapatite for Alveolar Bone Regeneration

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 60
Author(s):  
Jae Woon Lim ◽  
Kyoung-Je Jang ◽  
Hyunmok Son ◽  
Sangbae Park ◽  
Jae Eun Kim ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
High Speed ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Bone Tissue Regeneration ◽  
Calcium Deposition ◽  
Graft Material ◽  
Post Surgery ◽  
Equine Bone

Post-surgery failure of dental implants due to alveolar bone loss is currently critical, disturbing the quality of life of senior dental patients. To overcome this problem, bioceramic or bone graft material is loaded into the defect. However, connective tissue invasion instead of osteogenic tissue limits bone tissue regeneration. The guided bone regeneration concept was adapted to solve this problem and still has room for improvements, such as biochemical similarity or oriented structure. In this article, an aligned electrospun-guided bone regeneration barrier with xenograft equine bone-derived nano hydroxyapatite (EBNH-RB) was fabricated by electrospinning EBNH/PCL solution on high-speed rotating drum collector and fiber characterization, viability and differentiation enhancing properties of mesenchymal dental pulp stem cell on the barrier was determined. EBNH-RB showed biochemical and structural similarity to natural bone tissue electron microscopy image analysis and x-ray diffractometer analysis, and had a significantly better effect in promoting osteogenesis based on the increased bioceramic content by promoting cell viability, calcium deposition and osteogenic marker expression, suggesting that they can be successfully applied to regenerate alveolar bone as a guided bone regeneration barrier.

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