scholarly journals Optimalization of Extraction Conditions for Increasing Microalgal Lipid Yield by Using Accelerated Solvent Extraction Method (ASE) Based on the Orthogonal Array Design

10.5772/52475 ◽  
2012 ◽  
Author(s):  
Lin Rulong ◽  
Cai Wenxuan ◽  
Xing Bingpeng ◽  
Ke Xiurong
Keyword(s):  
Solvent Extraction ◽  
Orthogonal Array ◽  
Extraction Method ◽  
Accelerated Solvent Extraction ◽  
Orthogonal Array Design ◽  
Array Design ◽  
Lipid Yield ◽  
Solvent Extraction Method

A Comparison of the Accelerated Solvent Extraction Method to the Soxhlet Method in the Extraction of Cotton Fiber Wax

2019 ◽  
Vol 6 (1) ◽  
pp. 15-20
Author(s):  
Chanel Angelique Fortier ◽  
Michael Santiago Cintron ◽  
Donna Peralta ◽  
Terri Von Hoven ◽  
Krystal Fontenot ◽  
...  
Keyword(s):  
Solvent Extraction ◽  
Cotton Fiber ◽  
Extraction Method ◽  
Accelerated Solvent Extraction ◽  
Solvent Extraction Method ◽  
Soxhlet Method

Automated accelerated solvent extraction method for total lipid analysis of microalgae

2020 ◽  
Vol 51 ◽  
pp. 102080
Author(s):  
Wei Chen ◽  
Yongmei Liu ◽  
Lirong Song ◽  
Milton Sommerfeld ◽  
Qiang Hu
Keyword(s):  
Solvent Extraction ◽  
Total Lipid ◽  
Extraction Method ◽  
Lipid Analysis ◽  
Accelerated Solvent Extraction ◽  
Solvent Extraction Method

scholarly journals Adapting the Accelerated Solvent Extraction Method for Resin and Rubber Determination in Guayule Using the BÜCHI Speed Extractor

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 183
Author(s):  
Juana Rozalén ◽  
María de las Mercedes García-Martínez ◽  
María Engracia Carrión ◽  
Manuel Carmona ◽  
Horacio López-Córcoles ◽  
...  
Keyword(s):  
Solvent Extraction ◽  
Extraction Method ◽  
Accelerated Solvent Extraction ◽  
Interlaboratory Comparisons ◽  
Parthenium Argentatum ◽  
Rubber Content ◽  
Alternative Source ◽  
Promising Alternative ◽  
Solvent Extraction Method ◽  
Optimized Conditions

Guayule (Parthenium argentatum Gray) is a promising alternative source to Hevea brasiliensis for the production of natural rubber, which can reach levels of 8–9% under industrialized farming conditions. The most common method for determining rubber concentration is by accelerated solvent extraction (ASE), a technique developed by the Dionex Corporation and almost exclusively performed with the Dionex ASE-200 or 350 systems. Herein, it is sought to apply and adapt the most common methods used in the literature for the Dionex system to another extraction platform, the BÜCHI Speed Extractor E-914. Results showed that using a sand sandwich method to confine the sample in the center and exploiting a larger cell volume (80 mL) for extraction prevents the occurrence of overpressure and problems with clogging. Under optimized conditions, the coefficient of variation was <15% for both resin quantification for samples containing 5.0–15.8% of resin and for rubber quantification for samples with 1.7–10.3% rubber content. The extraction time for resin (2 cycles of 5 min each) was smaller than for rubber (2 cycles of 20 min each). It would be interesting to carry out interlaboratory comparisons to standardize the method at an international level.

Formulation Development of Tamoxifen Loaded Lipid Nanoparticle by Taguchi (L12 (2 11)) Orthogonal Array Design

2020 ◽  
Vol 16 ◽  
Author(s):  
Poovi Ganesan ◽  
N Damodharan
Keyword(s):  
Orthogonal Array ◽  
Drug Loading ◽  
Optimization Technique ◽  
Pharmaceutical Products ◽  
Water Soluble ◽  
Nanostructured Lipid Carrier ◽  
Orthogonal Array Design ◽  
Formulation Development ◽  
Array Design ◽  
Lipid Nanoparticle

Background: A better understanding of the biopharmaceutical and physicochemical properties of drugs and the pharmaco-technical factors would be of great help for developing pharmaceutical products. But, it is extremely difficult to study the effect of each variable and interaction among them through the conventional approach Objective: To screen the most influential factors affecting the particle size (PS) of lipid nanoparticle (LNPs) (solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC)) for poorly water-soluble BCS class-II drug like tamoxifen (TMX) to improve its oral bioavailability and to reduce its toxicity to tolerable limits using Taguchi (L12 (2 11)) orthogonal array design by applying computer optimization technique. Results: The size of all LNPs formulations prepared as per the experimental design varied between 172 nm and 3880 μm, polydispersity index between 0.033 and 1.00, encapsulation efficiency between 70.8% and 75.7%, and drug loading between 5.84% and 9.68%. The study showed spherical and non-spherical as well as aggregated and non-aggregated LNPs. Besides, it showed no interaction and amorphous form of the drug in LNPs formulation. The Blank NLCs exhibited no cytotoxicity on MCF-7 cells as compared to TMX solution, SLNs (F5) and NLCs (F12) suggests that the cause of cell death is primarily from the effect of TMX present in NLCs. Conclusions: The screening study clearly showed the importance of different individual factors significant effect for the LNPs formulation development and its overall performance in an in-vitro study with minimum experimentation thus saving considerable time, efforts, and resources for further in-depth study.

Supercritical CO2 Extraction of Rhizoma Atractylodis macrocephalae

2012 ◽  
Vol 549 ◽  
pp. 60-64
Author(s):  
Zhen Huang ◽  
Xiao Han Shi ◽  
Shao Fang Liu ◽  
Wei Juan Jiang
Keyword(s):  
Particle Size ◽  
Orthogonal Array ◽  
Time Pressure ◽  
Extraction Yield ◽  
Extraction Time ◽  
Time Varying ◽  
Orthogonal Array Design ◽  
Array Design ◽  
Different Sources

An orthogonal array design was employed for optimizing the supercritical CO2 extraction of Rhizoma Atractylodis Macrocephalae. The extraction was performed at temperature from 40 to 60oC, pressure from 15 to 35MPa, extraction time varying from 30 to 90min and particle size spanning from 20 to 80 mesh. The results reflect that the extraction yield is more significantly influenced by the extraction time, pressure and particle size but less by temperature. The experiments show that the extraction yield obviously increases with increasing pressure, different from the literatures. In terms of the sample origin, a comparison shows that outstanding differences exist among the extraction yields from different sources.

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