scholarly journals Biochemical and Histopathological Toxicity by Multiple Drug Administration

10.5772/35624 ◽  
2012 ◽  
Author(s):  
Zeeshan Feroz ◽  
Rafeeq Alam
Keyword(s):  
Drug Administration ◽  
Multiple Drug

Drug interactions and multiple drug administration

1977 ◽  
Vol 22 (3) ◽  
pp. 322-328 ◽  
Author(s):  
Franklin E. May ◽  
Ronald B. Stewart ◽  
Leighton E. Cluff
Keyword(s):  
Drug Interactions ◽  
Drug Administration ◽  
Multiple Drug

scholarly journals Simultaneous Determination of Several Antiepileptic Drugs and Its Clinical Application to Some Cases of Multiple-Drug Administration

1982 ◽  
Vol 102 (11) ◽  
pp. 1067-1073 ◽  
Author(s):  
JUICHI SATO ◽  
AKIKO SAITO ◽  
EIJI OWADA ◽  
KEIJI ITO ◽  
TETSUSHI GOTO ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Antiepileptic Drugs ◽  
Clinical Application ◽  
Drug Administration ◽  
Multiple Drug

scholarly journals Optimizing Multiple Drug Administration from Depot by Applying Pharmacokinetic Concepts

2020 ◽  
Vol 24 (4) ◽  
pp. 337-348
Author(s):  
Krasimira Prodanova ◽  
Keyword(s):  
Drug Administration ◽  
Dosage Regimen ◽  
Bacterial Infections ◽  
Impulsive Control ◽  
Plasma Concentrations ◽  
Aminoglycoside Antibiotic ◽  
Compartment Model ◽  
Multiple Drug ◽  
Optimization Approach ◽  
Drug Concentrations

For the multiple drug administration from therapeutic reasons it is important to maintain the concentration in the blood plasma in an appropriate range. In the present paper an optimization approach is developed to determine drug dosage regimen to achieve the desired plasma concentrations after application from depot, i.e. oral, muscular, subcutant. The developed methodology allows the optimization of both the dose and the dosage interval. Performance of the developed methodology is evaluated by computing bias and precision of the estimated trough and peak drug concentrations that are reached after dosage regimen determinations. This article focuses on an optimal impulsive control of compartment model to individualise dosage regimens of Amikacin in the context of extended dosage intervals. Amikacin is an aminoglycoside antibiotic used to treat various bacterial infections.

Nanotechnology-based drug delivery systems as potential for skin application: a review

2020 ◽  
Vol 27 ◽  
Author(s):  
Franciele Garcia Baveloni ◽  
Bruno Vincenzo Fiod Riccio ◽  
Leonardo Delello Di Filippo ◽  
Mariza Aires Fernandes ◽  
Andréia Bagliotti Meneguin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Large Body ◽  
Delivery Systems ◽  
Multiple Drug ◽  
Promising Alternative ◽  
Administration Routes ◽  
Main Barrier

: Administration of substances through the skin represents a promising alternative, in relation to others drug administration routes, due to its large body surface area, in order to offer ideal and multiple sites for drug administration. In addition, the administration of drugs through the skin avoids first-pass metabolism, allowing an increase in the bioavailability of drugs, as well as reducing their side effects. However, the stratum corneum (SC) comprises the main barrier of protection against external agents, mainly due to its structure, composition and physicochemical properties, becoming the main limitation for the administration of substances through the skin. In view of the above, pharmaceutical technology has allowed the development of multiple drug delivery systems (DDS), which include liquid crystals (LC), cubosomes, liposomes, polymeric nanoparticles (PNP), nanoemulsions (NE), as well as cyclodextrins (CD) and dendrimers (DND). It appears that the DDS circumvents the problems of drug absorption through the SC layer of the skin, ensuring the release of the drug, as well as optimizing the therapeutic effect local. This review aims to highlight the DDS that include LC, cubosomes, lipid systems, PNP, as well as CD and DND, to optimize topical skin therapies.

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