Drug interactions and multiple drug administration

1977 ◽  
Vol 22 (3) ◽  
pp. 322-328 ◽  
Author(s):  
Franklin E. May ◽  
Ronald B. Stewart ◽  
Leighton E. Cluff
Keyword(s):  
Drug Interactions ◽  
Drug Administration ◽  
Multiple Drug

Multiple drug interactions - induced serotonin syndrome: a case report

2009 ◽  
Vol 34 (4) ◽  
pp. 485-487 ◽  
Author(s):  
E. Montané ◽  
A. Barriocanal ◽  
I. Isern ◽  
T. Parajon ◽  
J. Costa
Keyword(s):  
Case Report ◽  
Drug Interactions ◽  
Serotonin Syndrome ◽  
Multiple Drug

Multiple drug interactions induced hyperammonemic encephalopathy in Dravet Syndrome

2021 ◽  
Vol 429 ◽  
pp. 119144
Author(s):  
Carmen Calvello ◽  
Angela Borrelli ◽  
Marialuisa Silla ◽  
Nicola Tambasco ◽  
Lucilla Parnetti ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Dravet Syndrome ◽  
Multiple Drug ◽  
Hyperammonemic Encephalopathy

scholarly journals POTENTIAL DRUG INTERACTIONS IN HYPERTENSIVE PATIENTS IN LIWA DISTRICT HOSPITAL, LAMPUNG BARAT, INDONESIA

2017 ◽  
Vol 9 (6) ◽  
pp. 134
Author(s):  
Erna Yanti ◽  
Erna - Kristin ◽  
Alfi Yasmina
Keyword(s):  
Drug Interactions ◽  
District Hospital ◽  
Antihypertensive Agents ◽  
Potential Interaction ◽  
Multiple Drug ◽  
Potential Drug ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Multiple Drugs ◽  
Potential Interactions

Objective: Patients with hypertension often suffer from other comorbidities, resulting in prescriptions of multiple drugs to treat the conditions. Multiple drug treatment is potentially associated with drug interactions. This aim of the study was to assess potential drug interactions in hypertensive patients in Liwa District Hospital.Methods: The design of the study was cross-sectional. The prescriptions for in-patients with essential hypertension in the Internal Medicine Unit in Liwa District Hospital during April-December 2012 were collected. Potential drug interactions were analyzed with the Drug Interaction Facts version 4.0, and classified into minor, significant, and serious.Results: A total of 60 hypertensive patients were included. They were prescribed 265 prescriptions, with a median total of 6 (range 1-21) drugs prescribed per prescription. There were 1616 potential drug interactions, with 6 (1-31) potential interactions per prescription. Most interactions (75.6%) were classified as significant. Serious potential interactions were most common in the combinations of diltiazem-amlodipine and spironolactone-potassium chloride, while significant potential interaction may occur most often with the combinations of calcium chloride-amlodipine and bisoprolol-amlodipine.Conclusion: Numerous potential drug interactions might occur in hypertensive patients, and most interactions were significant in severity. The largest proportion of the interactions occurred between antihypertensive agents and other drugs. 

scholarly journals Oxycodone Involvement in Drug Abuse Deaths. II. Evidence for Toxic Multiple Drug-Drug Interactions

2004 ◽  
Vol 28 (7) ◽  
pp. 616-624 ◽  
Author(s):  
E. J. Cone ◽  
R. V. Fant ◽  
J. M. Rohay ◽  
Y. H. Caplan ◽  
M. Ballina ◽  
...  
Keyword(s):  
Drug Abuse ◽  
Drug Interactions ◽  
Multiple Drug

Rhabdomyolysis in an elderly multitreated patient: Multiple drug interactions after statin withdrawal

2014 ◽  
Vol 336 (1-2) ◽  
pp. 284-287 ◽  
Author(s):  
Federica Ginanneschi ◽  
Nila Volpi ◽  
Fabio Giannini ◽  
Raffaele Rocchi ◽  
Donatella Donati ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Multiple Drug

scholarly journals Drug interactions with statins

2013 ◽  
Vol 63 (3) ◽  
pp. 277-293 ◽  
Author(s):  
Anida Causevic-Ramosevac ◽  
Sabina Semiz
Keyword(s):  
Cytochrome P450 ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Liver Enzymes ◽  
Drug Transporters ◽  
Multiple Drug ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase ◽  
Asymptomatic Elevation

AbstractThe 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are generally well tolerated as monotherapy. Statins are associated with two important adverse effects, asymptomatic elevation in liver enzymes and myopathy. Myopathy is most likely to occur when statins are administered with other drugs. Statins are substrates of multiple drug transporters (including OAT- -P1B1, BCRP and MDR1) and several cytochrome P450 (CYP) enzymes (including CYP3A4, CYP2C8, CYP2C19, and CYP2C9). Possible adverse effects of statins can occur due to interactions in concomitant use of drugs that substantially inhibit or induce their methabolic pathway. This review summarizes the most important interactions of statins.

New Drug Review-Ezogabine (Potiga): Seizing the seizure

2011 ◽  
Vol 1 (6) ◽  
pp. 135-136
Author(s):  
Misty L. Gonzalez
Keyword(s):  
Clinical Trial ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Drug Administration ◽  
Mechanism Of Action ◽  
New Drug ◽  
Clinical Trial Evidence ◽  
Clinically Significant ◽  
Trial Evidence ◽  
Drug Review

Ezogabine was approved by the Food and Drug Administration (FDA) in June of 2011. This article reviews clinically significant aspects of this new drug including: the FDA-approved indications, mechanism of action, administration, drug interactions, adverse effects, clinical trial evidence, innovative properties and place in therapy.

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