scholarly journals Antioxidant Defense and Lipid Peroxide Level in Liver and Kidneys of Lead Exposed Rats

2000 ◽  
Vol 13 (10) ◽  
pp. 1433-1439
Author(s):  
R. C. Patra ◽  
D. Swarup ◽  
S. K. Dwivedi
1979 ◽  
Vol 21 (1) ◽  
pp. 104-107 ◽  
Author(s):  
Yuzo Sato ◽  
Nigishi Hotta ◽  
Nobuo Sakamoto ◽  
Shigeru Matsuoka ◽  
Nobuko Ohishi ◽  
...  

2002 ◽  
Vol 80 (7) ◽  
pp. 742-749 ◽  
Author(s):  
Ileana Petcu ◽  
Nicoleta Moisoi ◽  
Diana Savu ◽  
B Constantinescu

The experiment examined biological responses produced by combined sequential exposure to low-level tritium contamination, followed by challenging irradiation with fast neutrons. Modifications of endogenous antioxidant potential of different organs in rats were discussed in relation to tissue radiosensitivity. Rats pre-contaminated to 7 cGy and 35 cGy have been additionally irradiated to 1 Gy with fast neutrons. Lipid peroxide level was determined in liver, kidney, small intestine, spleen, bone marrow, and plasma. Reduced glutathione (GSH) level and glucose-6-phosphate dehydrogenase (G6PDH) activity were determined in erythrocytes. An in vitro thymidine uptake assay was performed in isolated bone marrow cells. The lipid peroxide level decreased significantly only in liver and kidney from rats pre-exposed to 35 cGy. For small intestine and spleen, tissues of comparatively higher radiosensitivity, no induced radioprotection was observed, as reflected in the homeostasis of the lipid peroxides. The same behavior was observed in bone marrow, the most radiosensitive tissue studied. However, the bone marrow thymidine-incorporation assay revealed a possible adaptive-type reaction in rats pre-exposed to 35 cGy. We conclude that for radiosensitive tissues pre-exposure to chronic low doses of low linear energy transfer (LET) irradiation has no protective effect on their antioxidant status, whereas a protective effect is observed in radioresistent tissues.Key words: induced radioprotection, tritium contamination, lipid peroxides, thymidine uptake, tissue radiosensitivity, antioxidant defense.


2002 ◽  
Vol 54 (1-2) ◽  
pp. 11-18
Author(s):  
Radoslav Zikic ◽  
Andras Stajn ◽  
Sladjan Pavlovic ◽  
Branka Ognjanovic ◽  
Snezana Maletic ◽  
...  

The influence of acute hypoxia on glucose, pyruvate, lipid peroxide (LP) reduced glutathione (GSH) concentrations and lactate level in the whole blood of carp (Cyprinus carpio L) under aquarium conditions were studied. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), the concentrations of ATP and ADP and ATP/ADP ratio in the red blood cells (RBCs) were analyzed. Glutathione-S-transferase (GST) activity was determined in the plasma. Our experiments showed that short-term and long-term hypoxia causes significant changes of all examined haema-tological parameters. Increased concentration of LP and increased SOD CAT and GST activities, as well as a decreased GSH-Px activity showed that under hypoxic conditions oxidative stress and RBCs damage were produced.


2005 ◽  
Vol 26 (7) ◽  
pp. 589-594 ◽  
Author(s):  
Shinji Harakawa ◽  
Noboru Inoue ◽  
Takuya Hori ◽  
Koji Tochio ◽  
Tatsuya Kariya ◽  
...  

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