scholarly journals Effects of Tributyrin on Intestinal Energy Status, Antioxidative Capacity and Immune Response to Lipopolysaccharide Challenge in Broilers

2015 ◽  
Vol 28 (12) ◽  
pp. 1784-1793 ◽  
Author(s):  
Jiaolong Li ◽  
Yongqing Hou ◽  
Dan Yi ◽  
Jun Zhang ◽  
Lei Wang ◽  
...  
Keyword(s):  
Immune Response ◽  
Antioxidative Capacity ◽  
Energy Status ◽  
Lipopolysaccharide Challenge

Effects of berberine on the growth performance, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers

2019 ◽  
Vol 90 (9) ◽  
pp. 1229-1238 ◽  
Author(s):  
Li Yang ◽  
Gang Liu ◽  
Xiaorui Liang ◽  
Mengmeng Wang ◽  
Xiaoqing Zhu ◽  
...  
Keyword(s):  
Immune Response ◽  
Growth Performance ◽  
Antioxidative Capacity ◽  
Lipopolysaccharide Challenge

scholarly journals The transcription factors TFEB and TFE3 link the FLCN-AMPK signaling axis to innate immune response and pathogen resistance

2018 ◽  
Author(s):  
Leeanna El-Houjeiri ◽  
Elite Possik ◽  
Tarika Vijayaraghavan ◽  
Mathieu Paquette ◽  
José A Martina ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Mammalian Cells ◽  
Pathogen Resistance ◽  
Innate Immune ◽  
Negative Regulator ◽  
Energy Status ◽  
Rapid Reduction ◽  
Coupling Energy ◽  
Mtorc1 Signaling

AbstractTFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. UsingC. elegansand mammalian models, we report that the master metabolic modulator 5’-AMP-activated protein kinase (AMPK) and its negative regulator Folliculin (FLCN) act upstream of TFEB/TFE3 in the innate immune response, independently of the mTORC1 signaling pathway. In nematodes, loss of FLCN or overexpression of AMPK conferred pathogen resistanceviaactivation of TFEB/TFE3-dependent antimicrobial genes, while ablation of total AMPK activity abolished this phenotype. Similarly, in mammalian cells, loss of FLCN or pharmacological activation of AMPK induced TFEB/TFE3-dependent pro-inflammatory cytokine expression. Importantly, a rapid reduction in cellular ATP levels in murine macrophages was observed upon lipopolysaccharide (LPS) treatment accompanied by an acute AMPK activation and TFEB nuclear localization. These results uncover an ancient, highly conserved and pharmacologically actionable mechanism coupling energy status with innate immunity.

Changes in the adenylate energy charge ofNippostrorigylus brasiliensisandNematodirus battusduring the development of immunity to these nematodes in their hosts

Parasitology ◽  
1978 ◽  
Vol 76 (2) ◽  
pp. 211-220 ◽  
Author(s):  
A. J. Ballantyne ◽  
M. J. Sharpe ◽  
D. L. Lee
Keyword(s):  
Immune Response ◽  
Energy Charge ◽  
Nippostrongylus Brasiliensis ◽  
Adenylate Energy Charge ◽  
Energy Status ◽  
High Level

SummaryInfection of rats with 2000 infective juveniles ofNippostrongylus brasiliensisand of lambs with 60000 infective juveniles ofNematodirus battusresults in a well-marked immunity to these nematodes in their respective hosts. There is a fall in the adenylate energy charge value of these nematodes during the course of these infections, reaching values of 0·37 in males and 0·27 in females ofN. brasiliensis, and 0·31 in males and 0·23 in females ofN. battustowards the end of the infections. In hosts given relatively small numbers of infective juveniles, the values for the nematodes removed from the hosts late in the infection remain at a relatively high level. These results indicate that the immune response of the host may affect the energy status of these nematodes, and this could help to explain their subsequent expulsion from the immune host.

Consumption of green tea epigallocatechin-3-gallate enhances systemic immune response, antioxidative capacity and HPA axis functions in aged male swiss albino mice

2017 ◽  
Vol 18 (3) ◽  
pp. 367-382 ◽  
Author(s):  
Rohit Sharma ◽  
Anamika Sharma ◽  
Amita Kumari ◽  
Pankaj Markand Kulurkar ◽  
Rajneesh Raj ◽  
...  
Keyword(s):  
Immune Response ◽  
Green Tea ◽  
Hpa Axis ◽  
Antioxidative Capacity ◽  
Systemic Immune Response ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Effect of yeast-derived products on systemic innate immune response of broiler chickens following a lipopolysaccharide challenge

2016 ◽  
Vol 95 (10) ◽  
pp. 2266-2273 ◽  
Author(s):  
M. Alizadeh ◽  
J.C. Rodriguez-Lecompte ◽  
A. Yitbarek ◽  
S. Sharif ◽  
G. Crow ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Broiler Chickens ◽  
Innate Immune ◽  
Lipopolysaccharide Challenge
Sign in / Sign up

Export Citation Format

Share Document