scholarly journals Regular chromogranin A monitoring facilitated the early detection of a gastrointestinal neuroendocrine tumour in a patient with type 1 diabetes

2020 ◽  
Vol 71 (5) ◽  
pp. 483-484
Author(s):  
Zoltan Herold ◽  
Andrea Uhlyarik ◽  
Magdolna Herold ◽  
Peter Nagy ◽  
Gergely Denes Huszty ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Early Detection ◽  
Chromogranin A ◽  
Neuroendocrine Tumour

scholarly journals The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

2015 ◽  
Vol 156 (5) ◽  
pp. 163-170
Author(s):  
Zoltán Herold ◽  
Péter Nagy ◽  
Attila Patócs ◽  
Anikó Somogyi
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Chromogranin A ◽  
Neuroendocrine Tumour ◽  
Secretory Granules ◽  
Neuroendocrine Cells ◽  
Diabetic Patients ◽  
Autoreactive Cells

Chromogranin-A is a member of the granine protein family. It is produced in neuroendocrine cells via secretory granules. Many cleavage proteins are formed from chromogranin-A, from which some have well known biological activity, while the function of others is not yet fully known. Serum chromogranin-A levels are used in neuroendocrine tumour diagnostics. Recent studies showed that one of its cleavage protein, WE-14 may also play a role in the development of type 1 diabetes. WE-14 may function as an autoantigen for T-cells involved in the destruction of β-cells. This mechanism was previously observed only in non-obese diabetic mice. Novel results show that WE-14 also serves as a target for autoreactive cells in newly diagnosed type 1 diabetic patients as well, which reaction can be increased with transglutaminase. In this paper the authors summarize the recent knowledge about chromogranin-A and its potential role in the pathomechanism of type 1 diabetes mellitus. Orv. Hetil., 2015, 156(5), 163–170.

scholarly journals The early detection of atherosclerosis in type 1 diabetes: why, how and what to do about it

2019 ◽  
Vol 8 (1) ◽  
pp. 14-27 ◽  
Author(s):  
Alicia Jenkins ◽  
Andrzej Januszewski ◽  
David O’Neal
Keyword(s):  
Type 1 Diabetes ◽  
Early Detection

MicroRNAs and Diabetes Mellitus Type 1

2021 ◽  
Vol 17 ◽  
Author(s):  
Farbod Bahreini ◽  
Elham Rayzan ◽  
Nima Rezaei
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Early Detection ◽  
Molecular Mechanisms ◽  
Target Genes ◽  
Islet Cells ◽  
Diabetes Mellitus Type 1 ◽  
Complementary Sequence ◽  
Multiple Organs

: Type 1 diabetes mellitus is a multifactorial, progressive, autoimmune disease with a strong genetic feature that can affect multiple organs, including kidney, eyes, and nerves. Early detection of type 1 diabetes can help critically to avoid serious damages to these organs. MicroRNAs are small RNA molecules that act in post-transcriptional gene regulation by attaching to the complementary sequence in the 3'-untranslated region of their target genes. Alterations in the expression of microRNA coding genes are extensively reported in several diseases such as type 1 diabetes. Presenting non-invasive biomarkers for early detection of type 1 diabetes by quantifying microRNAs gene expression level can be an influential step in biotechnology and medicine. This review discusses the area of microRNAs dysregulation in type 1 diabetes and affected molecular mechanisms involved in pancreatic islet cells formation and dysregulation in the expression of inflammatory elements as well as pro-inflammatory cytokines.

scholarly journals Early Detection of Hypoglycemia in Type 1 Diabetes Using Heart Rate Variability Measured by a Wearable Device

Diabetes Care ◽  
2019 ◽  
Vol 42 (4) ◽  
pp. 689-692 ◽  
Author(s):  
Marleen Olde Bekkink ◽  
Mats Koeneman ◽  
Bastiaan E. de Galan ◽  
Sebastian J. Bredie
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Early Detection ◽  
Wearable Device

Urinary Markers for Early Detection of Diabetic Nephropathy in Type 1 Diabetes Mellitus

2015 ◽  
Vol 61 ◽  
pp. 479-488
Author(s):  
Shawkia S. Abd El-Halim ◽  
Awatif M. Abd El-Maksoud ◽  
Mohammed A. Abdel-Rahman
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Early Detection ◽  
Type 1 Diabetes Mellitus ◽  
Urinary Markers

scholarly journals Chronic complications of type 1 diabetes mellitus in children

2012 ◽  
Vol 19 (3) ◽  
pp. 301-309 ◽  
Author(s):  
Maricela Cobuz ◽  
Claudiu Cobuz
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Early Detection ◽  
Diabetic Neuropathy ◽  
Disease Duration ◽  
Disease Onset ◽  
Chronic Complications ◽  
Factors Associated ◽  
Predicting Factors

Abstract Objectives: To evaluate the frequency of chronic complications and identify thepredicting factors that may be used for their early detection. Material and Method: The research group included 144 T1DM children with disease duration > 5 years ordisease onset during puberty. Complication screening included: full ophthalmologicexamination, UAE level determination, diabetic neuropathy assessment. Results: Retinopathy prevalence was 12.5 %. Factors associated with retinopathy were:hyperglycemia, duration of diabetes and dyslipidemia. Microalbuminuria wasdetected in 23 patients (15.97%) and correlated with HbA1c or insulin therapyregimen. Diabetic neuropathy prevalence (45.8%) was studied in relation to UAE.Peripheral somatic neuropathy was significantly correlated with the diabeticnephropathy stage. Autonomic neuropathy was detected only in 13.8% patients, yetits prevalence increased with the increase in UAE. Conclusions: Chronic diabeticcomplications are relatively less frequent as compared to adults, yet their evolutionis distinct due to the age-specific characteristics.

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