scholarly journals Bait and Trap: Enriching Autoreactive T Cells With β-Cell Antigen-Loading Biomaterial Scaffolds for Early Detection of Type 1 Diabetes

Diabetes ◽  
2017 ◽  
Vol 66 (8) ◽  
pp. 2066-2068
Author(s):  
Yong Fan
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Early Detection ◽  
Β Cell ◽  
Autoreactive T Cells ◽  
Cell Antigen ◽  
Biomaterial Scaffolds

scholarly journals Nonlinear Analysis for a Type-1 Diabetes Model with Focus on T-Cells and Pancreatic β-Cells Behavior

2020 ◽  
Vol 25 (2) ◽  
pp. 23
Author(s):  
Diana Gamboa ◽  
Carlos E. Vázquez ◽  
Paul J. Campos
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cell Population ◽  
Closed Loop ◽  
Pancreatic Β Cell ◽  
Activated Macrophages ◽  
Β Cells ◽  
Β Cell ◽  
Pancreatic Β Cells

Type-1 diabetes mellitus (T1DM) is an autoimmune disease that has an impact on mortality due to the destruction of insulin-producing pancreatic β -cells in the islets of Langerhans. Over the past few years, the interest in analyzing this type of disease, either in a biological or mathematical sense, has relied on the search for a treatment that guarantees full control of glucose levels. Mathematical models inspired by natural phenomena, are proposed under the prey–predator scheme. T1DM fits in this scheme due to the complicated relationship between pancreatic β -cell population growth and leukocyte population growth via the immune response. In this scenario, β -cells represent the prey, and leukocytes the predator. This paper studies the global dynamics of T1DM reported by Magombedze et al. in 2010. This model describes the interaction of resting macrophages, activated macrophages, antigen cells, autolytic T-cells, and β -cells. Therefore, the localization of compact invariant sets is applied to provide a bounded positive invariant domain in which one can ensure that once the dynamics of the T1DM enter into this domain, they will remain bounded with a maximum and minimum value. Furthermore, we analyzed this model in a closed-loop scenario based on nonlinear control theory, and proposed bases for possible control inputs, complementing the model with them. These entries are based on the existing relationship between cell–cell interaction and the role that they play in the unchaining of a diabetic condition. The closed-loop analysis aims to give a deeper understanding of the impact of autolytic T-cells and the nature of the β -cell population interaction with the innate immune system response. This analysis strengthens the proposal, providing a system free of this illness—that is, a condition wherein the pancreatic β -cell population holds and there are no antigen cells labeled by the activated macrophages.

scholarly journals Evidence for In Vivo Primed and Expanded Autoreactive T Cells as a Specific Feature of Patients with Type 1 Diabetes

2007 ◽  
Vol 179 (9) ◽  
pp. 5785-5792 ◽  
Author(s):  
Paolo Monti ◽  
Miriam Scirpoli ◽  
Andrea Rigamonti ◽  
Anya Mayr ◽  
Annika Jaeger ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Autoreactive T Cells

scholarly journals Variation in the CTLA4 3′UTR has phenotypic consequences for autoreactive T cells and associates with genetic risk for type 1 diabetes

2015 ◽  
Vol 17 (1) ◽  
pp. 75-78 ◽  
Author(s):  
V M de Jong ◽  
A Zaldumbide ◽  
A R van der Slik ◽  
S Laban ◽  
B P C Koeleman ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Genetic Risk ◽  
Autoreactive T Cells

scholarly journals Dendritic Cell-Directed CTLA-4 Engagement during Pancreatic β Cell Antigen Presentation Delays Type 1 Diabetes

2010 ◽  
Vol 184 (12) ◽  
pp. 6695-6708 ◽  
Author(s):  
Subha Karumuthil-Melethil ◽  
Nicolas Perez ◽  
Ruobing Li ◽  
Bellur S. Prabhakar ◽  
Mark J. Holterman ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Dendritic Cell ◽  
Antigen Presentation ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Cell Antigen

Direct ex vivo Enumeration of CD8 T Cells Specific for β-cell Autoantigens by Peptide-HLA Multimers in Type 1 Diabetes

2010 ◽  
Vol 135 ◽  
pp. S21
Author(s):  
Anna Skowera ◽  
Sefina Arif ◽  
Anna Zaremba ◽  
Colin Dayan ◽  
Bart Roep ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cd8 T Cells ◽  
Ex Vivo ◽  
Β Cell ◽  
Hla Multimers

scholarly journals Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells

Diabetes ◽  
2018 ◽  
Vol 67 (11) ◽  
pp. 2319-2328
Author(s):  
Kaitlin R. Carroll ◽  
Eileen E. Elfers ◽  
Joseph J. Stevens ◽  
Jonathan P. McNally ◽  
David A. Hildeman ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Autoreactive T Cells ◽  
Onset Type ◽  
New Onset

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes

Diabetologia ◽  
2014 ◽  
Vol 58 (1) ◽  
pp. 140-148 ◽  
Author(s):  
Yuxing Zhao ◽  
Nicholas A. Scott ◽  
Stacey Fynch ◽  
Lorraine Elkerbout ◽  
W. Wei-Lynn Wong ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Mouse Model ◽  
Death Receptor ◽  
Autoreactive T Cells

scholarly journals Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes

Diabetes ◽  
2007 ◽  
Vol 56 (9) ◽  
pp. 2251-2259 ◽  
Author(s):  
R. Li ◽  
N. Perez ◽  
S. Karumuthil-Melethil ◽  
C. Vasu
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Type 1 Diabetes ◽  
Autoreactive T Cells
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