Histological Studies Of The Teratogenic Effects Of Oral Administration Of Aspilia Africana (Asteraceae) Leaf Extract On The Developing Liver Of Neonatal Wistar Rats

10.5580/2025 ◽  
2007 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Oral Administration ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Teratogenic Effects ◽  
Histological Studies

scholarly journals Ameliorative Potential of Clerodendrum volubile Ethanol Leaf Extract on Doxorubicin-Induced Hepatorenal Toxicities in Rats

2021 ◽  
Vol 1 (1) ◽  
pp. 1-13
Author(s):  
Adejuwon A. Adeneye ◽  
Olufunke E. Olorundare ◽  
Akinyele O. Akinsola ◽  
Daniel A. Sanni ◽  
James M. Ntambi ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Total Bilirubin ◽  
Kidney Injury ◽  
Hepatic Function ◽  
Serum Electrolytes ◽  
Histological Studies ◽  
Male Wistar Rats ◽  
Liver And Kidney ◽  
Free Radicals Scavenging

Background and Purpose: Hepatorenal toxicity is a side effect of the anthracycline cytotoxic antibiotics, doxorubicin that is used in cancer treatment. The study investigated the ameliorative potential of Clerodendrum volubile ethanol leaf extract (CVE) on doxorubicin (DOX)-induced hepatorenal toxicities. Methods: Male Wistar rats were pretreated with Clerodendrum volubile ethanol leaf extract (50 - 400 mg/kg/day, p.o) followed by intraperitoneal injection of 2.5 mg/kg of DOX on alternate days for 14 days. Hepatorenal toxicity was assessed using renal function parameters (serum electrolytes, blood urea and creatinine), hepatic function endpoints [aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), total protein (TP), albumin (ALB) and total bilirubin (TB)]. In addition, the antioxidant activity in the kidney and liver tissues were assayed and histological studies of these tissues were also conducted. Results: Oral pretreatment with 50 mg/kg/day, 100 mg/kg/day, 200 mg/kg/day and 400 mg/kg/day of CVE remarkably ameliorated DOX-induced liver and kidney injury by lowering the serum ALT, AST, ALP, Cr and BUN levels. CVE pretreatment remarkably ameliorated DOX-induced increases in the CAT, SOD and GPx activities and MDA levels compared to the DOX-treated rats. The biochemical changes were corroborated by improvements in the DOX-induced histological lesions seen in the hepatic and renal tissues examined. Conclusions: Overall, these findings suggest that Clerodendrum volubile ethanol leaf extract elicits protective effect against DOX-induced hepatorenal toxicities mediated primarily via oxidative stress suppression and improvement in the free radicals scavenging activities of CVE.

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